Molecular pathogenesis of sporadic colorectal cancers
Abstract Colorectal cancer (CRC) results from the progressive accumulation of genetic and epigenetic alterations that lead to the transformation of normal colonic mucosa to adenocarcinoma. Approximately 75% of CRCs are sporadic and occur in people without genetic predisposition or family history of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2016-01-01
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| Series: | Chinese Journal of Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40880-015-0066-y |
| _version_ | 1818139869170368512 |
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| author | Hidetsugu Yamagishi Hajime Kuroda Yasuo Imai Hideyuki Hiraishi |
| author_facet | Hidetsugu Yamagishi Hajime Kuroda Yasuo Imai Hideyuki Hiraishi |
| author_sort | Hidetsugu Yamagishi |
| collection | DOAJ |
| description | Abstract Colorectal cancer (CRC) results from the progressive accumulation of genetic and epigenetic alterations that lead to the transformation of normal colonic mucosa to adenocarcinoma. Approximately 75% of CRCs are sporadic and occur in people without genetic predisposition or family history of CRC. During the past two decades, sporadic CRCs were classified into three major groups according to frequently altered/mutated genes. These genes have been identified by linkage analyses of cancer-prone families and by individual mutation analyses of candidate genes selected on the basis of functional data. In the first half of this review, we describe the genetic pathways of sporadic CRCs and their clinicopathologic features. Recently, large-scale genome analyses have detected many infrequently mutated genes as well as a small number of frequently mutated genes. These infrequently mutated genes are likely described in a limited number of pathways. Gene-oriented models of CRC progression are being replaced by pathway-oriented models. In the second half of this review, we summarize the present knowledge of this research field and discuss its prospects. |
| first_indexed | 2024-12-11T10:34:56Z |
| format | Article |
| id | doaj.art-b44c34568bc0415fa4e80ab5b4c88f67 |
| institution | Directory Open Access Journal |
| issn | 1944-446X |
| language | English |
| last_indexed | 2024-12-11T10:34:56Z |
| publishDate | 2016-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Journal of Cancer |
| spelling | doaj.art-b44c34568bc0415fa4e80ab5b4c88f672022-12-22T01:10:44ZengBMCChinese Journal of Cancer1944-446X2016-01-013511810.1186/s40880-015-0066-yMolecular pathogenesis of sporadic colorectal cancersHidetsugu Yamagishi0Hajime Kuroda1Yasuo Imai2Hideyuki Hiraishi3Department of Diagnostic Pathology, Dokkyo Medical UniversityDepartment of Pathology, International University of Health and Welfare HospitalDepartment of Diagnostic Pathology, Dokkyo Medical UniversityDepartment of Gastroenterology, Dokkyo Medical UniversityAbstract Colorectal cancer (CRC) results from the progressive accumulation of genetic and epigenetic alterations that lead to the transformation of normal colonic mucosa to adenocarcinoma. Approximately 75% of CRCs are sporadic and occur in people without genetic predisposition or family history of CRC. During the past two decades, sporadic CRCs were classified into three major groups according to frequently altered/mutated genes. These genes have been identified by linkage analyses of cancer-prone families and by individual mutation analyses of candidate genes selected on the basis of functional data. In the first half of this review, we describe the genetic pathways of sporadic CRCs and their clinicopathologic features. Recently, large-scale genome analyses have detected many infrequently mutated genes as well as a small number of frequently mutated genes. These infrequently mutated genes are likely described in a limited number of pathways. Gene-oriented models of CRC progression are being replaced by pathway-oriented models. In the second half of this review, we summarize the present knowledge of this research field and discuss its prospects.http://link.springer.com/article/10.1186/s40880-015-0066-ySporadic colorectal cancerPathogenesisMorphologyLarge-scale genome analysisGenetic pathway |
| spellingShingle | Hidetsugu Yamagishi Hajime Kuroda Yasuo Imai Hideyuki Hiraishi Molecular pathogenesis of sporadic colorectal cancers Chinese Journal of Cancer Sporadic colorectal cancer Pathogenesis Morphology Large-scale genome analysis Genetic pathway |
| title | Molecular pathogenesis of sporadic colorectal cancers |
| title_full | Molecular pathogenesis of sporadic colorectal cancers |
| title_fullStr | Molecular pathogenesis of sporadic colorectal cancers |
| title_full_unstemmed | Molecular pathogenesis of sporadic colorectal cancers |
| title_short | Molecular pathogenesis of sporadic colorectal cancers |
| title_sort | molecular pathogenesis of sporadic colorectal cancers |
| topic | Sporadic colorectal cancer Pathogenesis Morphology Large-scale genome analysis Genetic pathway |
| url | http://link.springer.com/article/10.1186/s40880-015-0066-y |
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