Multi-system diseases and death trajectory of metabolic dysfunction-associated fatty liver disease: findings from the UK Biobank
Abstract Background Metabolic dysfunction-associated fatty liver disease (MAFLD) is a newly defined condition encompassing hepatic steatosis and metabolic dysfunction. However, the relationship between MAFLD and multi-system diseases remains unclear, and the time-dependent sequence of these diseases...
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | BMC Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12916-023-03080-6 |
| _version_ | 1797452372306296832 |
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| author | Yu Jia Dongze Li Yi You Jing Yu Wenli Jiang Yi Liu Rui Zeng Zhi Wan Yi Lei Xiaoyang Liao |
| author_facet | Yu Jia Dongze Li Yi You Jing Yu Wenli Jiang Yi Liu Rui Zeng Zhi Wan Yi Lei Xiaoyang Liao |
| author_sort | Yu Jia |
| collection | DOAJ |
| description | Abstract Background Metabolic dysfunction-associated fatty liver disease (MAFLD) is a newly defined condition encompassing hepatic steatosis and metabolic dysfunction. However, the relationship between MAFLD and multi-system diseases remains unclear, and the time-dependent sequence of these diseases requires further clarification. Methods After propensity score matching, 163,303 MAFLD subjects and 163,303 matched subjects were included in the community-based UK Biobank study. The International Classification of Diseases, Tenth Revision (ICD-10), was used to reclassify medical conditions into 490 and 16 specific causes of death. We conducted a disease trajectory analysis to map the key pathways linking MAFLD to various health conditions, providing an overview of their interconnections. Results Participants aged 59 (51–64) years, predominantly males (62.5%), were included in the study. During the 12.9-year follow-up period, MAFLD participants were found to have a higher risk of 113 medical conditions and eight causes of death, determined through phenome-wide association analysis using Cox regression models. Temporal disease trajectories of MAFLD were established using disease pairing, revealing intermediary diseases such as asthma, diabetes, hypertension, hypothyroid conditions, tobacco abuse, diverticulosis, chronic ischemic heart disease, obesity, benign tumors, and inflammatory arthritis. These trajectories primarily resulted in acute myocardial infarction, disorders of fluid, electrolyte, and acid–base balance, infectious gastroenteritis and colitis, and functional intestinal disorders. Regarding death trajectories of MAFLD, malignant neoplasms, cardiovascular diseases, and respiratory system deaths were the main causes, and organ failure, infective disease, and internal environment disorder were the primary end-stage conditions. Disease trajectory analysis based on the level of genetic susceptibility to MAFLD yielded consistent results. Conclusions Individuals with MAFLD have a risk of a number of different medical conditions and causes of death. Notably, these diseases and potential causes of death constitute many pathways that may be promising targets for preventing general health decline in patients with MAFLD. |
| first_indexed | 2024-03-09T15:08:09Z |
| format | Article |
| id | doaj.art-b44c964401904a00a6ba730f920d6662 |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-03-09T15:08:09Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-b44c964401904a00a6ba730f920d66622023-11-26T13:34:16ZengBMCBMC Medicine1741-70152023-10-0121111310.1186/s12916-023-03080-6Multi-system diseases and death trajectory of metabolic dysfunction-associated fatty liver disease: findings from the UK BiobankYu Jia0Dongze Li1Yi You2Jing Yu3Wenli Jiang4Yi Liu5Rui Zeng6Zhi Wan7Yi Lei8Xiaoyang Liao9General Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan UniversityDepartment of Emergency Medicine, West China Hospital, Sichuan UniversitySchool of Computer Science, Sichuan UniversityDepartment of Emergency Medicine, West China Hospital, Sichuan UniversityGeneral Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan UniversityDepartment of Emergency Medicine, West China Hospital, Sichuan UniversityDepartment of Cardiology, West China Hospital, West China School of Medicine, Sichuan UniversityDepartment of Emergency Medicine, West China Hospital, Sichuan UniversityGeneral Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan UniversityGeneral Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan UniversityAbstract Background Metabolic dysfunction-associated fatty liver disease (MAFLD) is a newly defined condition encompassing hepatic steatosis and metabolic dysfunction. However, the relationship between MAFLD and multi-system diseases remains unclear, and the time-dependent sequence of these diseases requires further clarification. Methods After propensity score matching, 163,303 MAFLD subjects and 163,303 matched subjects were included in the community-based UK Biobank study. The International Classification of Diseases, Tenth Revision (ICD-10), was used to reclassify medical conditions into 490 and 16 specific causes of death. We conducted a disease trajectory analysis to map the key pathways linking MAFLD to various health conditions, providing an overview of their interconnections. Results Participants aged 59 (51–64) years, predominantly males (62.5%), were included in the study. During the 12.9-year follow-up period, MAFLD participants were found to have a higher risk of 113 medical conditions and eight causes of death, determined through phenome-wide association analysis using Cox regression models. Temporal disease trajectories of MAFLD were established using disease pairing, revealing intermediary diseases such as asthma, diabetes, hypertension, hypothyroid conditions, tobacco abuse, diverticulosis, chronic ischemic heart disease, obesity, benign tumors, and inflammatory arthritis. These trajectories primarily resulted in acute myocardial infarction, disorders of fluid, electrolyte, and acid–base balance, infectious gastroenteritis and colitis, and functional intestinal disorders. Regarding death trajectories of MAFLD, malignant neoplasms, cardiovascular diseases, and respiratory system deaths were the main causes, and organ failure, infective disease, and internal environment disorder were the primary end-stage conditions. Disease trajectory analysis based on the level of genetic susceptibility to MAFLD yielded consistent results. Conclusions Individuals with MAFLD have a risk of a number of different medical conditions and causes of death. Notably, these diseases and potential causes of death constitute many pathways that may be promising targets for preventing general health decline in patients with MAFLD.https://doi.org/10.1186/s12916-023-03080-6Metabolic dysfunction-associated fatty liver diseaseDisease trajectoryMortalityNonalcoholic fatty liver disease |
| spellingShingle | Yu Jia Dongze Li Yi You Jing Yu Wenli Jiang Yi Liu Rui Zeng Zhi Wan Yi Lei Xiaoyang Liao Multi-system diseases and death trajectory of metabolic dysfunction-associated fatty liver disease: findings from the UK Biobank BMC Medicine Metabolic dysfunction-associated fatty liver disease Disease trajectory Mortality Nonalcoholic fatty liver disease |
| title | Multi-system diseases and death trajectory of metabolic dysfunction-associated fatty liver disease: findings from the UK Biobank |
| title_full | Multi-system diseases and death trajectory of metabolic dysfunction-associated fatty liver disease: findings from the UK Biobank |
| title_fullStr | Multi-system diseases and death trajectory of metabolic dysfunction-associated fatty liver disease: findings from the UK Biobank |
| title_full_unstemmed | Multi-system diseases and death trajectory of metabolic dysfunction-associated fatty liver disease: findings from the UK Biobank |
| title_short | Multi-system diseases and death trajectory of metabolic dysfunction-associated fatty liver disease: findings from the UK Biobank |
| title_sort | multi system diseases and death trajectory of metabolic dysfunction associated fatty liver disease findings from the uk biobank |
| topic | Metabolic dysfunction-associated fatty liver disease Disease trajectory Mortality Nonalcoholic fatty liver disease |
| url | https://doi.org/10.1186/s12916-023-03080-6 |
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