Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET

Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET

Abstract Background The brain is a challenging target for antibody-based positron emission tomography (immunoPET) imaging due to the restricted access of antibody-based ligands through the blood–brain barrier (BBB). To overcome this physiological obstacle, we have previously developed bispecific ant...

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Bibliographic Details
Main Authors: Eva Schlein, Johanna Rokka, Luke R. Odell, Sara Lopes van den Broek, Matthias M. Herth, Umberto M. Battisti, Stina Syvänen, Dag Sehlin, Jonas Eriksson
Format: Article
Language:English
Published: SpringerOpen 2024-03-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Inverse electron demand Diels–Alder reaction
IEDDA
Pre-targeting
Tetrazine
Trans-cyclooctene
TCO
Online Access:https://doi.org/10.1186/s41181-024-00250-6

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