Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve
The brain-derived neurotrophic factor (BDNF) is an extensively studied neurotrophin es sential for both developing the brain and maintaining adult brain function. In the adult hippocampus, BDNF is critical for maintaining adult neurogenesis. Adult hippocampal neurogenesis is involved not only in mem...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/4/3543 |
| _version_ | 1797620556331220992 |
|---|---|
| author | Yoko Amagase Ryuichi Kambayashi Atsushi Sugiyama Yoshinori Takei |
| author_facet | Yoko Amagase Ryuichi Kambayashi Atsushi Sugiyama Yoshinori Takei |
| author_sort | Yoko Amagase |
| collection | DOAJ |
| description | The brain-derived neurotrophic factor (BDNF) is an extensively studied neurotrophin es sential for both developing the brain and maintaining adult brain function. In the adult hippocampus, BDNF is critical for maintaining adult neurogenesis. Adult hippocampal neurogenesis is involved not only in memory formation and learning ability, but also mood regulation and stress responses. Accordingly, decreased levels of BDNF, accompanied by low levels of adult neurogenesis, occurs in brains of older adults with impaired cognitive function and in those of patients with major depression disorder. Therefore, elucidating the mechanisms that maintain hippocampal BDNF levels is biologically and clinically important. It has been revealed that signalling from peripheral tissues contribute to the regulation of BDNF expression in the brain across the blood–brain barrier. Moreover, recent studies indicated evidence that neuronal pathways can also be a mechanism by which peripheral tissues signal to the brain for the regulation of BDNF expression. In this review, we give an overview of the current status in the regulation of central BDNF expression by peripheral signalling, with a special interest in the regulation of hippocampal BDNF levels by signals via the vagus nerve. Finally, we discuss the relationship between signalling from peripheral tissues and age-associated control of central BDNF expression. |
| first_indexed | 2024-03-11T08:43:17Z |
| format | Article |
| id | doaj.art-b44ece3f80eb437b8f99cca07bbc0b77 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:43:17Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b44ece3f80eb437b8f99cca07bbc0b772023-11-16T21:01:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244354310.3390/ijms24043543Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus NerveYoko Amagase0Ryuichi Kambayashi1Atsushi Sugiyama2Yoshinori Takei3Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 4-20-1 Nasahara, Takatsuki 569-1094, JapanDepartment of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, JapanDepartment of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, JapanDepartment of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, JapanThe brain-derived neurotrophic factor (BDNF) is an extensively studied neurotrophin es sential for both developing the brain and maintaining adult brain function. In the adult hippocampus, BDNF is critical for maintaining adult neurogenesis. Adult hippocampal neurogenesis is involved not only in memory formation and learning ability, but also mood regulation and stress responses. Accordingly, decreased levels of BDNF, accompanied by low levels of adult neurogenesis, occurs in brains of older adults with impaired cognitive function and in those of patients with major depression disorder. Therefore, elucidating the mechanisms that maintain hippocampal BDNF levels is biologically and clinically important. It has been revealed that signalling from peripheral tissues contribute to the regulation of BDNF expression in the brain across the blood–brain barrier. Moreover, recent studies indicated evidence that neuronal pathways can also be a mechanism by which peripheral tissues signal to the brain for the regulation of BDNF expression. In this review, we give an overview of the current status in the regulation of central BDNF expression by peripheral signalling, with a special interest in the regulation of hippocampal BDNF levels by signals via the vagus nerve. Finally, we discuss the relationship between signalling from peripheral tissues and age-associated control of central BDNF expression.https://www.mdpi.com/1422-0067/24/4/3543adult neurogenesisBDNFvagus nerveperitoneal cellsgut microbiota |
| spellingShingle | Yoko Amagase Ryuichi Kambayashi Atsushi Sugiyama Yoshinori Takei Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve International Journal of Molecular Sciences adult neurogenesis BDNF vagus nerve peritoneal cells gut microbiota |
| title | Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve |
| title_full | Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve |
| title_fullStr | Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve |
| title_full_unstemmed | Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve |
| title_short | Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve |
| title_sort | peripheral regulation of central brain derived neurotrophic factor expression through the vagus nerve |
| topic | adult neurogenesis BDNF vagus nerve peritoneal cells gut microbiota |
| url | https://www.mdpi.com/1422-0067/24/4/3543 |
| work_keys_str_mv | AT yokoamagase peripheralregulationofcentralbrainderivedneurotrophicfactorexpressionthroughthevagusnerve AT ryuichikambayashi peripheralregulationofcentralbrainderivedneurotrophicfactorexpressionthroughthevagusnerve AT atsushisugiyama peripheralregulationofcentralbrainderivedneurotrophicfactorexpressionthroughthevagusnerve AT yoshinoritakei peripheralregulationofcentralbrainderivedneurotrophicfactorexpressionthroughthevagusnerve |