Multimodal Bacteriochlorophyll Theranostic Agent
<p>The complimentary ability of different noninvasive imaging technologies with therapeutic modalities can be used in tandem providing high-resolution and highly sensitive imaging of events at the molecular and cellular level providing a means for image-guided therapy. There is increasing inte...
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| Format: | Article |
| Language: | English |
| Published: |
Ivyspring International Publisher
2011-01-01
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| Series: | Theranostics |
| Online Access: | http://www.thno.org/v01p0354.htm |
| _version_ | 1819171837035151360 |
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| author | Tracy W.B. Liu, Juan Chen, Laura Burgess, Weiguo Cao, Jiyun Shi, Brian C. Wilson, Gang Zheng |
| author_facet | Tracy W.B. Liu, Juan Chen, Laura Burgess, Weiguo Cao, Jiyun Shi, Brian C. Wilson, Gang Zheng |
| author_sort | Tracy W.B. Liu, Juan Chen, Laura Burgess, Weiguo Cao, Jiyun Shi, Brian C. Wilson, Gang Zheng |
| collection | DOAJ |
| description | <p>The complimentary ability of different noninvasive imaging technologies with therapeutic modalities can be used in tandem providing high-resolution and highly sensitive imaging of events at the molecular and cellular level providing a means for image-guided therapy. There is increasing interest in using porphyrin-based photosensitizers as theranostics to take advantages of their near-infrared fluorescent properties for imaging and their strong singlet oxygen generation abilities for photodynamic therapy. Here we report a targeted multimodal bacteriochlorophyll theranostic probe. This probe consists of a bacteriochlorophyll derivative, a pharmacokinetics modification peptide linker and folate for targeted delivery to folate receptor expressing cancer cells. We demonstrate its multimodal theranostic capability, its folate receptor targeting ability and its utility for both NIR fluorescence imaging and photodynamic therapy purposes both <i>in vitro</i> and <i>in vivo</i>.</p> |
| first_indexed | 2024-12-22T19:57:38Z |
| format | Article |
| id | doaj.art-b44f29d463fd4761b4358d7bc06b2f3e |
| institution | Directory Open Access Journal |
| issn | 1838-7640 |
| language | English |
| last_indexed | 2024-12-22T19:57:38Z |
| publishDate | 2011-01-01 |
| publisher | Ivyspring International Publisher |
| record_format | Article |
| series | Theranostics |
| spelling | doaj.art-b44f29d463fd4761b4358d7bc06b2f3e2022-12-21T18:14:23ZengIvyspring International PublisherTheranostics1838-76402011-01-0111354362Multimodal Bacteriochlorophyll Theranostic AgentTracy W.B. Liu, Juan Chen, Laura Burgess, Weiguo Cao, Jiyun Shi, Brian C. Wilson, Gang Zheng<p>The complimentary ability of different noninvasive imaging technologies with therapeutic modalities can be used in tandem providing high-resolution and highly sensitive imaging of events at the molecular and cellular level providing a means for image-guided therapy. There is increasing interest in using porphyrin-based photosensitizers as theranostics to take advantages of their near-infrared fluorescent properties for imaging and their strong singlet oxygen generation abilities for photodynamic therapy. Here we report a targeted multimodal bacteriochlorophyll theranostic probe. This probe consists of a bacteriochlorophyll derivative, a pharmacokinetics modification peptide linker and folate for targeted delivery to folate receptor expressing cancer cells. We demonstrate its multimodal theranostic capability, its folate receptor targeting ability and its utility for both NIR fluorescence imaging and photodynamic therapy purposes both <i>in vitro</i> and <i>in vivo</i>.</p>http://www.thno.org/v01p0354.htm |
| spellingShingle | Tracy W.B. Liu, Juan Chen, Laura Burgess, Weiguo Cao, Jiyun Shi, Brian C. Wilson, Gang Zheng Multimodal Bacteriochlorophyll Theranostic Agent Theranostics |
| title | Multimodal Bacteriochlorophyll Theranostic Agent |
| title_full | Multimodal Bacteriochlorophyll Theranostic Agent |
| title_fullStr | Multimodal Bacteriochlorophyll Theranostic Agent |
| title_full_unstemmed | Multimodal Bacteriochlorophyll Theranostic Agent |
| title_short | Multimodal Bacteriochlorophyll Theranostic Agent |
| title_sort | multimodal bacteriochlorophyll theranostic agent |
| url | http://www.thno.org/v01p0354.htm |
| work_keys_str_mv | AT tracywbliujuanchenlauraburgessweiguocaojiyunshibriancwilsongangzheng multimodalbacteriochlorophylltheranosticagent |