Analysis of predicted factors for bronchoalveolar lavage recovery failure: An observational study.
<h4>Background</h4>The bronchoalveolar lavage (BAL) recovery rate should generally be more than 30% for effective diagnosis. However, there have been no reports investigating a target bronchus for BAL, and the cause of BAL recovery failure is uncertain. Therefore, this study detected pre...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0275377 |
| _version_ | 1811242161609375744 |
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| author | Masafumi Shimoda Yoshiaki Tanaka Kozo Morimoto Taro Abe Reina Asaga Kei Nakajima Ken Okamura Kozo Yoshimori Ken Ohta |
| author_facet | Masafumi Shimoda Yoshiaki Tanaka Kozo Morimoto Taro Abe Reina Asaga Kei Nakajima Ken Okamura Kozo Yoshimori Ken Ohta |
| author_sort | Masafumi Shimoda |
| collection | DOAJ |
| description | <h4>Background</h4>The bronchoalveolar lavage (BAL) recovery rate should generally be more than 30% for effective diagnosis. However, there have been no reports investigating a target bronchus for BAL, and the cause of BAL recovery failure is uncertain. Therefore, this study detected predictive factors for BAL recovery failure through investigations on a target bronchus for BAL by using a 3D image analysis system. Therefore, this study detected predictive factors for BAL recovery failure.<h4>Materials and methods</h4>We retrospectively collected data from 338 adult patients who underwent BAL procedures at Fukujuji Hospital from June 2018-March 2022. Factors correlated with the BAL recovery rate were detected. Furthermore, the patients were divided into the failure group (recovery rate <30%; 36 patients) and the success group (recovery rate ≥30%; 302 patients), and data were compared between the two groups by analysing the target bronchus by using a 3D image analysis system.<h4>Results</h4>The patients in the failure group were older (median 74.5 years old [IQR 68.0-79.0] vs. median 70.0 years old [IQR 59.0-76.0], p = 0.016), more likely to be male (n = 27 [75.0%] vs. n = 172 [57.0%], p = 0.048), more likely to have COPD (n = 7 [19.4%] vs. n = 14 [4.6%], p = 0.003), and more likely to perform a target site of BAL other than the middle/lingual lobe (n = 11 [30.5%] vs. n = 35 [11.6%], p = 0.004) than those in the success group. The area of the bronchial wall was positively related to the recovery rate (r = 0.141, p = 0.009), and the area of the bronchial wall in the failure group was lower than that in the success group (median 10.5 mm2 [interquartile range (IQR) 8.1-14.6] vs. median 14.5 mm2 [11.4-19.0], p<0.001).<h4>Conclusion</h4>The study shows that a thin bronchial wall, COPD, and a target site of BAL other than the middle/lingual lobe were identified as the predicted factors for BAL recovery failure. The weakness of the bronchial wall might cause bronchial collapse during the BAL procedure. |
| first_indexed | 2024-04-12T13:47:42Z |
| format | Article |
| id | doaj.art-b4517d5474084b6a82a73fd2ec2812f1 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T13:47:42Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b4517d5474084b6a82a73fd2ec2812f12022-12-22T03:30:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01179e027537710.1371/journal.pone.0275377Analysis of predicted factors for bronchoalveolar lavage recovery failure: An observational study.Masafumi ShimodaYoshiaki TanakaKozo MorimotoTaro AbeReina AsagaKei NakajimaKen OkamuraKozo YoshimoriKen Ohta<h4>Background</h4>The bronchoalveolar lavage (BAL) recovery rate should generally be more than 30% for effective diagnosis. However, there have been no reports investigating a target bronchus for BAL, and the cause of BAL recovery failure is uncertain. Therefore, this study detected predictive factors for BAL recovery failure through investigations on a target bronchus for BAL by using a 3D image analysis system. Therefore, this study detected predictive factors for BAL recovery failure.<h4>Materials and methods</h4>We retrospectively collected data from 338 adult patients who underwent BAL procedures at Fukujuji Hospital from June 2018-March 2022. Factors correlated with the BAL recovery rate were detected. Furthermore, the patients were divided into the failure group (recovery rate <30%; 36 patients) and the success group (recovery rate ≥30%; 302 patients), and data were compared between the two groups by analysing the target bronchus by using a 3D image analysis system.<h4>Results</h4>The patients in the failure group were older (median 74.5 years old [IQR 68.0-79.0] vs. median 70.0 years old [IQR 59.0-76.0], p = 0.016), more likely to be male (n = 27 [75.0%] vs. n = 172 [57.0%], p = 0.048), more likely to have COPD (n = 7 [19.4%] vs. n = 14 [4.6%], p = 0.003), and more likely to perform a target site of BAL other than the middle/lingual lobe (n = 11 [30.5%] vs. n = 35 [11.6%], p = 0.004) than those in the success group. The area of the bronchial wall was positively related to the recovery rate (r = 0.141, p = 0.009), and the area of the bronchial wall in the failure group was lower than that in the success group (median 10.5 mm2 [interquartile range (IQR) 8.1-14.6] vs. median 14.5 mm2 [11.4-19.0], p<0.001).<h4>Conclusion</h4>The study shows that a thin bronchial wall, COPD, and a target site of BAL other than the middle/lingual lobe were identified as the predicted factors for BAL recovery failure. The weakness of the bronchial wall might cause bronchial collapse during the BAL procedure.https://doi.org/10.1371/journal.pone.0275377 |
| spellingShingle | Masafumi Shimoda Yoshiaki Tanaka Kozo Morimoto Taro Abe Reina Asaga Kei Nakajima Ken Okamura Kozo Yoshimori Ken Ohta Analysis of predicted factors for bronchoalveolar lavage recovery failure: An observational study. PLoS ONE |
| title | Analysis of predicted factors for bronchoalveolar lavage recovery failure: An observational study. |
| title_full | Analysis of predicted factors for bronchoalveolar lavage recovery failure: An observational study. |
| title_fullStr | Analysis of predicted factors for bronchoalveolar lavage recovery failure: An observational study. |
| title_full_unstemmed | Analysis of predicted factors for bronchoalveolar lavage recovery failure: An observational study. |
| title_short | Analysis of predicted factors for bronchoalveolar lavage recovery failure: An observational study. |
| title_sort | analysis of predicted factors for bronchoalveolar lavage recovery failure an observational study |
| url | https://doi.org/10.1371/journal.pone.0275377 |
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