Middle East Respiratory Syndrome Coronavirus Infection Dynamics and Antibody Responses among Clinically Diverse Patients, Saudi Arabia
Middle East respiratory syndrome coronavirus (MERS-CoV) shedding and antibody responses are not fully understood, particularly in relation to underlying medical conditions, clinical manifestations, and mortality. We enrolled MERS-CoV–positive patients at a hospital in Saudi Arabia and periodically c...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2019-04-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/25/4/18-1595_article |
| _version_ | 1819264873325920256 |
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| author | Hail M. Al-Abdely Claire M. Midgley Abdulrahim M. Alkhamis Glen R. Abedi Xiaoyan Lu Alison M. Binder Khalid H. Alanazi Azaibi Tamin Weam M. Banjar Sandra Lester Osman Abdalla Rebecca M. Dahl Mutaz Mohammed Suvang Trivedi Homoud S. Algarni Senthilkumar K. Sakthivel Abdullah Algwizani Fahad Bafaqeeh Abdullah Alzahrani Ali Abraheem Alsharef Raafat F. Alhakeem Hani A. Aziz Jokhdar Sameeh S. Ghazal Natalie J. Thornburg Dean D. Erdman Abdullah M. Assiri John T. Watson Susan I. Gerber |
| author_facet | Hail M. Al-Abdely Claire M. Midgley Abdulrahim M. Alkhamis Glen R. Abedi Xiaoyan Lu Alison M. Binder Khalid H. Alanazi Azaibi Tamin Weam M. Banjar Sandra Lester Osman Abdalla Rebecca M. Dahl Mutaz Mohammed Suvang Trivedi Homoud S. Algarni Senthilkumar K. Sakthivel Abdullah Algwizani Fahad Bafaqeeh Abdullah Alzahrani Ali Abraheem Alsharef Raafat F. Alhakeem Hani A. Aziz Jokhdar Sameeh S. Ghazal Natalie J. Thornburg Dean D. Erdman Abdullah M. Assiri John T. Watson Susan I. Gerber |
| author_sort | Hail M. Al-Abdely |
| collection | DOAJ |
| description | Middle East respiratory syndrome coronavirus (MERS-CoV) shedding and antibody responses are not fully understood, particularly in relation to underlying medical conditions, clinical manifestations, and mortality. We enrolled MERS-CoV–positive patients at a hospital in Saudi Arabia and periodically collected specimens from multiple sites for real-time reverse transcription PCR and serologic testing. We conducted interviews and chart abstractions to collect clinical, epidemiologic, and laboratory information. We found that diabetes mellitus among survivors was associated with prolonged MERS-CoV RNA detection in the respiratory tract. Among case-patients who died, development of robust neutralizing serum antibody responses during the second and third week of illness was not sufficient for patient recovery or virus clearance. Fever and cough among mildly ill patients typically aligned with RNA detection in the upper respiratory tract; RNA levels peaked during the first week of illness. These findings should be considered in the development of infection control policies, vaccines, and antibody therapeutics. |
| first_indexed | 2024-12-23T20:36:24Z |
| format | Article |
| id | doaj.art-b451ffaadeef4d2fb8e4e78e0251a48d |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-23T20:36:24Z |
| publishDate | 2019-04-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-b451ffaadeef4d2fb8e4e78e0251a48d2022-12-21T17:32:04ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592019-04-0125475376610.3201/eid2504.181595Middle East Respiratory Syndrome Coronavirus Infection Dynamics and Antibody Responses among Clinically Diverse Patients, Saudi ArabiaHail M. Al-AbdelyClaire M. MidgleyAbdulrahim M. AlkhamisGlen R. AbediXiaoyan LuAlison M. BinderKhalid H. AlanaziAzaibi TaminWeam M. BanjarSandra LesterOsman AbdallaRebecca M. DahlMutaz MohammedSuvang TrivediHomoud S. AlgarniSenthilkumar K. SakthivelAbdullah AlgwizaniFahad BafaqeehAbdullah AlzahraniAli Abraheem AlsharefRaafat F. AlhakeemHani A. Aziz JokhdarSameeh S. GhazalNatalie J. ThornburgDean D. ErdmanAbdullah M. AssiriJohn T. WatsonSusan I. GerberMiddle East respiratory syndrome coronavirus (MERS-CoV) shedding and antibody responses are not fully understood, particularly in relation to underlying medical conditions, clinical manifestations, and mortality. We enrolled MERS-CoV–positive patients at a hospital in Saudi Arabia and periodically collected specimens from multiple sites for real-time reverse transcription PCR and serologic testing. We conducted interviews and chart abstractions to collect clinical, epidemiologic, and laboratory information. We found that diabetes mellitus among survivors was associated with prolonged MERS-CoV RNA detection in the respiratory tract. Among case-patients who died, development of robust neutralizing serum antibody responses during the second and third week of illness was not sufficient for patient recovery or virus clearance. Fever and cough among mildly ill patients typically aligned with RNA detection in the upper respiratory tract; RNA levels peaked during the first week of illness. These findings should be considered in the development of infection control policies, vaccines, and antibody therapeutics.https://wwwnc.cdc.gov/eid/article/25/4/18-1595_articleMiddle East respiratory syndromecoronavirus infectionsdiabetes mellituskineticsviral loadantibody response |
| spellingShingle | Hail M. Al-Abdely Claire M. Midgley Abdulrahim M. Alkhamis Glen R. Abedi Xiaoyan Lu Alison M. Binder Khalid H. Alanazi Azaibi Tamin Weam M. Banjar Sandra Lester Osman Abdalla Rebecca M. Dahl Mutaz Mohammed Suvang Trivedi Homoud S. Algarni Senthilkumar K. Sakthivel Abdullah Algwizani Fahad Bafaqeeh Abdullah Alzahrani Ali Abraheem Alsharef Raafat F. Alhakeem Hani A. Aziz Jokhdar Sameeh S. Ghazal Natalie J. Thornburg Dean D. Erdman Abdullah M. Assiri John T. Watson Susan I. Gerber Middle East Respiratory Syndrome Coronavirus Infection Dynamics and Antibody Responses among Clinically Diverse Patients, Saudi Arabia Emerging Infectious Diseases Middle East respiratory syndrome coronavirus infections diabetes mellitus kinetics viral load antibody response |
| title | Middle East Respiratory Syndrome Coronavirus Infection Dynamics and Antibody Responses among Clinically Diverse Patients, Saudi Arabia |
| title_full | Middle East Respiratory Syndrome Coronavirus Infection Dynamics and Antibody Responses among Clinically Diverse Patients, Saudi Arabia |
| title_fullStr | Middle East Respiratory Syndrome Coronavirus Infection Dynamics and Antibody Responses among Clinically Diverse Patients, Saudi Arabia |
| title_full_unstemmed | Middle East Respiratory Syndrome Coronavirus Infection Dynamics and Antibody Responses among Clinically Diverse Patients, Saudi Arabia |
| title_short | Middle East Respiratory Syndrome Coronavirus Infection Dynamics and Antibody Responses among Clinically Diverse Patients, Saudi Arabia |
| title_sort | middle east respiratory syndrome coronavirus infection dynamics and antibody responses among clinically diverse patients saudi arabia |
| topic | Middle East respiratory syndrome coronavirus infections diabetes mellitus kinetics viral load antibody response |
| url | https://wwwnc.cdc.gov/eid/article/25/4/18-1595_article |
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