Thiolation of Biopolymers for Developing Drug Delivery Systems with Enhanced Mechanical and Mucoadhesive Properties: A Review
Biopolymers are extensively used for developing drug delivery systems as they are easily available, economical, readily modified, nontoxic, biodegradable and biocompatible. Thiolation is a well reported approach for enhancing mucoadhesive and mechanical properties of polymers. In the present review...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/12/8/1803 |
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| author | Vivek Puri Ameya Sharma Pradeep Kumar Inderbir Singh |
| author_facet | Vivek Puri Ameya Sharma Pradeep Kumar Inderbir Singh |
| author_sort | Vivek Puri |
| collection | DOAJ |
| description | Biopolymers are extensively used for developing drug delivery systems as they are easily available, economical, readily modified, nontoxic, biodegradable and biocompatible. Thiolation is a well reported approach for enhancing mucoadhesive and mechanical properties of polymers. In the present review article, for the modification of biopolymers different thiolation methods and evaluation/characterization techniques have been discussed in detail. Reported literature on thiolated biopolymers with enhanced mechanical and mucoadhesive properties has been presented conspicuously in text as well as in tabular form. Patents filed by researchers on thiolated polymers have also been presented. In conclusion, thiolation is an easily reproducible and efficient method for customization of mucoadhesive and mechanical properties of biopolymers for drug delivery applications. |
| first_indexed | 2024-03-10T17:36:48Z |
| format | Article |
| id | doaj.art-b455af5f47554ac8bebb325bcb3addeb |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T17:36:48Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-b455af5f47554ac8bebb325bcb3addeb2023-11-20T09:50:01ZengMDPI AGPolymers2073-43602020-08-01128180310.3390/polym12081803Thiolation of Biopolymers for Developing Drug Delivery Systems with Enhanced Mechanical and Mucoadhesive Properties: A ReviewVivek Puri0Ameya Sharma1Pradeep Kumar2Inderbir Singh3Chitkara College of Pharmacy, Chitkara University, Punjab 140401, IndiaChitkara College of Pharmacy, Chitkara University, Punjab 140401, IndiaDepartment of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South AfricaChitkara College of Pharmacy, Chitkara University, Punjab 140401, IndiaBiopolymers are extensively used for developing drug delivery systems as they are easily available, economical, readily modified, nontoxic, biodegradable and biocompatible. Thiolation is a well reported approach for enhancing mucoadhesive and mechanical properties of polymers. In the present review article, for the modification of biopolymers different thiolation methods and evaluation/characterization techniques have been discussed in detail. Reported literature on thiolated biopolymers with enhanced mechanical and mucoadhesive properties has been presented conspicuously in text as well as in tabular form. Patents filed by researchers on thiolated polymers have also been presented. In conclusion, thiolation is an easily reproducible and efficient method for customization of mucoadhesive and mechanical properties of biopolymers for drug delivery applications.https://www.mdpi.com/2073-4360/12/8/1803thiolationbiopolymersdrug delivery systemsmechanical propertiesmucoadhesive propertiespatents |
| spellingShingle | Vivek Puri Ameya Sharma Pradeep Kumar Inderbir Singh Thiolation of Biopolymers for Developing Drug Delivery Systems with Enhanced Mechanical and Mucoadhesive Properties: A Review Polymers thiolation biopolymers drug delivery systems mechanical properties mucoadhesive properties patents |
| title | Thiolation of Biopolymers for Developing Drug Delivery Systems with Enhanced Mechanical and Mucoadhesive Properties: A Review |
| title_full | Thiolation of Biopolymers for Developing Drug Delivery Systems with Enhanced Mechanical and Mucoadhesive Properties: A Review |
| title_fullStr | Thiolation of Biopolymers for Developing Drug Delivery Systems with Enhanced Mechanical and Mucoadhesive Properties: A Review |
| title_full_unstemmed | Thiolation of Biopolymers for Developing Drug Delivery Systems with Enhanced Mechanical and Mucoadhesive Properties: A Review |
| title_short | Thiolation of Biopolymers for Developing Drug Delivery Systems with Enhanced Mechanical and Mucoadhesive Properties: A Review |
| title_sort | thiolation of biopolymers for developing drug delivery systems with enhanced mechanical and mucoadhesive properties a review |
| topic | thiolation biopolymers drug delivery systems mechanical properties mucoadhesive properties patents |
| url | https://www.mdpi.com/2073-4360/12/8/1803 |
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