Safety evaluation of early drain removal following pancreaticoduodenectomy: A single-center retrospective cohort study
ObjectivesThe effects of early drain removal (EDR) on postoperative complications after pancreaticoduodenectomy (PD) remains to be investigated. This single-center retrospective cohort study was designed to explore the safety of EDR after PD.MethodsA total of 112 patients undergoing PD with drain fl...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-09-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.993901/full |
| _version_ | 1811265527312547840 |
|---|---|
| author | Xuehai Xie Kai Chen Zonghao Liu Feng Wang Yongsu Ma Shupeng Zhang Zhijiang Shao Yinmo Yang Xiaodong Tian |
| author_facet | Xuehai Xie Kai Chen Zonghao Liu Feng Wang Yongsu Ma Shupeng Zhang Zhijiang Shao Yinmo Yang Xiaodong Tian |
| author_sort | Xuehai Xie |
| collection | DOAJ |
| description | ObjectivesThe effects of early drain removal (EDR) on postoperative complications after pancreaticoduodenectomy (PD) remains to be investigated. This single-center retrospective cohort study was designed to explore the safety of EDR after PD.MethodsA total of 112 patients undergoing PD with drain fluid amylase (DFA) on postoperative day (POD) 1 and 3 <= 5000 were divided into EDR and late drain removal (LDR). Propensity Score Matching (PSM) was used. We compared postoperative outcomes between two groups and explore the risk factors of total complications using univariate and multiple logistic regression analyses.ResultsNo statistical differences were found in primary outcomes, including Grade B/C postoperative pancreatic fistula (POPF) (Original cohort: 5.71% vs. 3.90%; P = 1.000; PSM cohort: 3.33% vs. 6.67%; P = 1.000), and total complications (Original cohort: 17.14% vs. 32.47%; P = 0.093; PSM cohort: 13.33% vs. 33.33%; P = 0.067). The EDR was associated with shorter in-hospital stay (Original cohort: 11 days vs. 15 days; P < 0.0001; PSM cohort: 11 days vs. 15 days; P < 0.0001).ConclusionsEDR on POD 3 is safe for patients undergoing PD with low risk of POPF. |
| first_indexed | 2024-04-12T20:25:24Z |
| format | Article |
| id | doaj.art-b457398e06dd43368c694301213192e4 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T20:25:24Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-b457398e06dd43368c694301213192e42022-12-22T03:17:53ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.993901993901Safety evaluation of early drain removal following pancreaticoduodenectomy: A single-center retrospective cohort studyXuehai Xie0Kai Chen1Zonghao Liu2Feng Wang3Yongsu Ma4Shupeng Zhang5Zhijiang Shao6Yinmo Yang7Xiaodong Tian8Department of General Surgery, Peking University First Hospital, Beijing, ChinaDepartment of General Surgery, Peking University First Hospital, Beijing, ChinaDepartment of General Surgery, Peking University First Hospital, Beijing, ChinaDepartment of Endoscopy Center, Peking University First Hospital, Beijing, ChinaDepartment of General Surgery, Peking University First Hospital, Beijing, ChinaDepartment of General Surgery, Tianjin Fifth Centre Hospital, Tianjin, ChinaDepartment of General Surgery, Tianjin Fifth Centre Hospital, Tianjin, ChinaDepartment of General Surgery, Peking University First Hospital, Beijing, ChinaDepartment of General Surgery, Peking University First Hospital, Beijing, ChinaObjectivesThe effects of early drain removal (EDR) on postoperative complications after pancreaticoduodenectomy (PD) remains to be investigated. This single-center retrospective cohort study was designed to explore the safety of EDR after PD.MethodsA total of 112 patients undergoing PD with drain fluid amylase (DFA) on postoperative day (POD) 1 and 3 <= 5000 were divided into EDR and late drain removal (LDR). Propensity Score Matching (PSM) was used. We compared postoperative outcomes between two groups and explore the risk factors of total complications using univariate and multiple logistic regression analyses.ResultsNo statistical differences were found in primary outcomes, including Grade B/C postoperative pancreatic fistula (POPF) (Original cohort: 5.71% vs. 3.90%; P = 1.000; PSM cohort: 3.33% vs. 6.67%; P = 1.000), and total complications (Original cohort: 17.14% vs. 32.47%; P = 0.093; PSM cohort: 13.33% vs. 33.33%; P = 0.067). The EDR was associated with shorter in-hospital stay (Original cohort: 11 days vs. 15 days; P < 0.0001; PSM cohort: 11 days vs. 15 days; P < 0.0001).ConclusionsEDR on POD 3 is safe for patients undergoing PD with low risk of POPF.https://www.frontiersin.org/articles/10.3389/fonc.2022.993901/fullpancreaticoduodenectomyearly drain removalpostoperative pancreatic fistulapostoperative complicationspancreatic cancer |
| spellingShingle | Xuehai Xie Kai Chen Zonghao Liu Feng Wang Yongsu Ma Shupeng Zhang Zhijiang Shao Yinmo Yang Xiaodong Tian Safety evaluation of early drain removal following pancreaticoduodenectomy: A single-center retrospective cohort study Frontiers in Oncology pancreaticoduodenectomy early drain removal postoperative pancreatic fistula postoperative complications pancreatic cancer |
| title | Safety evaluation of early drain removal following pancreaticoduodenectomy: A single-center retrospective cohort study |
| title_full | Safety evaluation of early drain removal following pancreaticoduodenectomy: A single-center retrospective cohort study |
| title_fullStr | Safety evaluation of early drain removal following pancreaticoduodenectomy: A single-center retrospective cohort study |
| title_full_unstemmed | Safety evaluation of early drain removal following pancreaticoduodenectomy: A single-center retrospective cohort study |
| title_short | Safety evaluation of early drain removal following pancreaticoduodenectomy: A single-center retrospective cohort study |
| title_sort | safety evaluation of early drain removal following pancreaticoduodenectomy a single center retrospective cohort study |
| topic | pancreaticoduodenectomy early drain removal postoperative pancreatic fistula postoperative complications pancreatic cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.993901/full |
| work_keys_str_mv | AT xuehaixie safetyevaluationofearlydrainremovalfollowingpancreaticoduodenectomyasinglecenterretrospectivecohortstudy AT kaichen safetyevaluationofearlydrainremovalfollowingpancreaticoduodenectomyasinglecenterretrospectivecohortstudy AT zonghaoliu safetyevaluationofearlydrainremovalfollowingpancreaticoduodenectomyasinglecenterretrospectivecohortstudy AT fengwang safetyevaluationofearlydrainremovalfollowingpancreaticoduodenectomyasinglecenterretrospectivecohortstudy AT yongsuma safetyevaluationofearlydrainremovalfollowingpancreaticoduodenectomyasinglecenterretrospectivecohortstudy AT shupengzhang safetyevaluationofearlydrainremovalfollowingpancreaticoduodenectomyasinglecenterretrospectivecohortstudy AT zhijiangshao safetyevaluationofearlydrainremovalfollowingpancreaticoduodenectomyasinglecenterretrospectivecohortstudy AT yinmoyang safetyevaluationofearlydrainremovalfollowingpancreaticoduodenectomyasinglecenterretrospectivecohortstudy AT xiaodongtian safetyevaluationofearlydrainremovalfollowingpancreaticoduodenectomyasinglecenterretrospectivecohortstudy |