Severe cutaneous drug reactions in Guinean children: a monocentric retrospective study of 35 cases
Background: Data on Severe cutaneous drug reactions (CADRs) are not common among in sub-Saharan Africa children. The purpose of this study was to document the clinical, etiological and evolutionary aspects of Severe CDRs in children hospitalized at the dermatology department of university hospitals...
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| Format: | Article |
| Language: | English |
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Our Dermatology Online
2018-04-01
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| Series: | Nasza Dermatologia Online |
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| Online Access: | http://www.odermatol.com/issue-in-html/2018-2-3-severe/ |
| _version_ | 1818063390369644544 |
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| author | Thierno Mamadou Tounkara Houleymatou Baldé Mohamed Maciré Soumah M’mah Bangoura Boh Fanta Diané Moussa Keita Mamadou Djouldé Kanté Fodé Amara Traoré Fodé Bangaly Sako Mariam Touré Alhussein Doumbouya Mohamed Cisse |
| author_facet | Thierno Mamadou Tounkara Houleymatou Baldé Mohamed Maciré Soumah M’mah Bangoura Boh Fanta Diané Moussa Keita Mamadou Djouldé Kanté Fodé Amara Traoré Fodé Bangaly Sako Mariam Touré Alhussein Doumbouya Mohamed Cisse |
| author_sort | Thierno Mamadou Tounkara |
| collection | DOAJ |
| description | Background: Data on Severe cutaneous drug reactions (CADRs) are not common among in sub-Saharan Africa children. The purpose of this study was to document the clinical, etiological and evolutionary aspects of Severe CDRs in children hospitalized at the dermatology department of university hospitals of Conakry.
Material and Methods: Retrospective study, conducted from 1 January 2000 to 31 December 2014. Were included all children aged 0-17 years hospitalized for severe CARDs. The data collected were Socio-demographic, clinical, para-clinical and evolution variables. The data was entered and analyzed using the Excel 8.0 software.
Results: During a study period, 4437 patients of all ages was hospitalized in dermatology department. 35 patients were included with an average age of 11.3 years and a sex ratio of 1.5. The main clinical patterns were: Stevens Johnson syndrome 37.14% (13/35) Lyell syndrome 25.71 % and generalized bullous fixed eruption 22.85%. The drug was identified as 32 patients (91.42%): Sulfadoxine–Pyriméthamine 40.62%, cotrimoxazole 21.85%, nevirapin 12.5%, ampicillin 6.25%, traditional Pharmacopoeia 6.25% and griseofulin 3.12%. It was taken following self-medication in 14 patients, including a parental initiative in 9 patients. 7 patients had a history of drug allergy and 4 were HIV positive. We recorded 5 deaths.
Conclusion: Our study confirms the rarity of severe CADRs in children. The importance of the sulfadoxine-pyrimethamine in the occurrence of severe CADRs in children is the particularity of our series. |
| first_indexed | 2024-12-10T14:19:20Z |
| format | Article |
| id | doaj.art-b45b0ff5eb5f4841a821aabf2804829e |
| institution | Directory Open Access Journal |
| issn | 2081-9390 |
| language | English |
| last_indexed | 2024-12-10T14:19:20Z |
| publishDate | 2018-04-01 |
| publisher | Our Dermatology Online |
| record_format | Article |
| series | Nasza Dermatologia Online |
| spelling | doaj.art-b45b0ff5eb5f4841a821aabf2804829e2022-12-22T01:45:15ZengOur Dermatology OnlineNasza Dermatologia Online2081-93902018-04-0192118122Severe cutaneous drug reactions in Guinean children: a monocentric retrospective study of 35 casesThierno Mamadou Tounkara0 Houleymatou Baldé1Mohamed Maciré Soumah2M’mah Bangoura3Boh Fanta Diané4 Moussa Keita5Mamadou Djouldé Kanté6 Fodé Amara Traoré7Fodé Bangaly Sako8Mariam Touré9Alhussein Doumbouya10 Mohamed Cisse111Department of Dermatology and Venerology, Teaching Hospital of Conakry and Gamal Abdel Nasser University, Conakry, Republic of Guinea1Department of Dermatology and Venerology, Teaching Hospital of Conakry and Gamal Abdel Nasser University, Conakry, Republic of Guinea1Department of Dermatology and Venerology, Teaching Hospital of Conakry and Gamal Abdel Nasser University, Conakry, Republic of GuineaDepartment of Pediatric, Teaching Hospital of Conakry and Gamal Abdel Nasser University, Conakry, Republic of Guinea1Department of Dermatology and Venerology, Teaching Hospital of Conakry and Gamal Abdel Nasser University, Conakry, Republic of Guinea1Department of Dermatology and Venerology, Teaching Hospital of Conakry and Gamal Abdel Nasser University, Conakry, Republic of Guinea1Department of Dermatology and Venerology, Teaching Hospital of Conakry and Gamal Abdel Nasser University, Conakry, Republic of GuineaDepartment of Infectious and Tropical Diseases, Teaching Hospital of Conakry and Gamal Abdel Nasser University, Conakry, Republic of Guinea Department of Infectious and Tropical Diseases, Teaching Hospital of Conakry and Gamal Abdel Nasser University, Conakry, Republic of Guinea Department of Dermatology and Venerology, Teaching Hospital of Conakry and Gamal Abdel Nasser University, Conakry, Republic of GuineaDepartment of Dermatology and Venerology, Teaching Hospital of Conakry and Gamal Abdel Nasser University, Conakry, Republic of GuineaDepartment of Dermatology and Venerology, Teaching Hospital of Conakry and Gamal Abdel Nasser University, Conakry, Republic of GuineaBackground: Data on Severe cutaneous drug reactions (CADRs) are not common among in sub-Saharan Africa children. The purpose of this study was to document the clinical, etiological and evolutionary aspects of Severe CDRs in children hospitalized at the dermatology department of university hospitals of Conakry. Material and Methods: Retrospective study, conducted from 1 January 2000 to 31 December 2014. Were included all children aged 0-17 years hospitalized for severe CARDs. The data collected were Socio-demographic, clinical, para-clinical and evolution variables. The data was entered and analyzed using the Excel 8.0 software. Results: During a study period, 4437 patients of all ages was hospitalized in dermatology department. 35 patients were included with an average age of 11.3 years and a sex ratio of 1.5. The main clinical patterns were: Stevens Johnson syndrome 37.14% (13/35) Lyell syndrome 25.71 % and generalized bullous fixed eruption 22.85%. The drug was identified as 32 patients (91.42%): Sulfadoxine–Pyriméthamine 40.62%, cotrimoxazole 21.85%, nevirapin 12.5%, ampicillin 6.25%, traditional Pharmacopoeia 6.25% and griseofulin 3.12%. It was taken following self-medication in 14 patients, including a parental initiative in 9 patients. 7 patients had a history of drug allergy and 4 were HIV positive. We recorded 5 deaths. Conclusion: Our study confirms the rarity of severe CADRs in children. The importance of the sulfadoxine-pyrimethamine in the occurrence of severe CADRs in children is the particularity of our series.http://www.odermatol.com/issue-in-html/2018-2-3-severe/Severe cutaneous drug reactionChildrenToxic epidermal necrolysis |
| spellingShingle | Thierno Mamadou Tounkara Houleymatou Baldé Mohamed Maciré Soumah M’mah Bangoura Boh Fanta Diané Moussa Keita Mamadou Djouldé Kanté Fodé Amara Traoré Fodé Bangaly Sako Mariam Touré Alhussein Doumbouya Mohamed Cisse Severe cutaneous drug reactions in Guinean children: a monocentric retrospective study of 35 cases Nasza Dermatologia Online Severe cutaneous drug reaction Children Toxic epidermal necrolysis |
| title | Severe cutaneous drug reactions in Guinean children: a monocentric retrospective study of 35 cases |
| title_full | Severe cutaneous drug reactions in Guinean children: a monocentric retrospective study of 35 cases |
| title_fullStr | Severe cutaneous drug reactions in Guinean children: a monocentric retrospective study of 35 cases |
| title_full_unstemmed | Severe cutaneous drug reactions in Guinean children: a monocentric retrospective study of 35 cases |
| title_short | Severe cutaneous drug reactions in Guinean children: a monocentric retrospective study of 35 cases |
| title_sort | severe cutaneous drug reactions in guinean children a monocentric retrospective study of 35 cases |
| topic | Severe cutaneous drug reaction Children Toxic epidermal necrolysis |
| url | http://www.odermatol.com/issue-in-html/2018-2-3-severe/ |
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