Hyperphosphorylation and cleavage at D421 enhance tau secretion.

Hyperphosphorylation and cleavage at D421 enhance tau secretion.

It is well established that tau pathology propagates in a predictable manner in Alzheimer's disease (AD). Moreover, tau accumulates in the cerebrospinal fluid (CSF) of AD's patients. The mechanisms underlying the propagation of tau pathology and its accumulation in the CSF remain to be elu...

Full description

Bibliographic Details
Main Authors: Vanessa Plouffe, Nguyen-Vi Mohamed, Jessica Rivest-McGraw, Johanne Bertrand, Michel Lauzon, Nicole Leclerc
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3352936?pdf=render

Similar Items

Similar Items