Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent suppressive and regulative properties. MDSCs’ strong immunosuppressive potential creates new possibilities to treat chronic inflammation and autoimmune diseases or induce tolerance towards transplantation. Here,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.933847/full |
| _version_ | 1828258010042990592 |
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| author | Chiel van Geffen Constantin Heiss Astrid Deißler Saeed Kolahian |
| author_facet | Chiel van Geffen Constantin Heiss Astrid Deißler Saeed Kolahian |
| author_sort | Chiel van Geffen |
| collection | DOAJ |
| description | Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent suppressive and regulative properties. MDSCs’ strong immunosuppressive potential creates new possibilities to treat chronic inflammation and autoimmune diseases or induce tolerance towards transplantation. Here, we summarize and critically discuss different pharmacological approaches which modulate the generation, activation, and recruitment of MDSCs in vitro and in vivo, and their potential role in future immunosuppressive therapy. |
| first_indexed | 2024-04-13T02:48:51Z |
| format | Article |
| id | doaj.art-b45ee1843f3f42a3886df209bd377b4b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T02:48:51Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b45ee1843f3f42a3886df209bd377b4b2022-12-22T03:05:54ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.933847933847Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammationChiel van GeffenConstantin HeissAstrid DeißlerSaeed KolahianMyeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent suppressive and regulative properties. MDSCs’ strong immunosuppressive potential creates new possibilities to treat chronic inflammation and autoimmune diseases or induce tolerance towards transplantation. Here, we summarize and critically discuss different pharmacological approaches which modulate the generation, activation, and recruitment of MDSCs in vitro and in vivo, and their potential role in future immunosuppressive therapy.https://www.frontiersin.org/articles/10.3389/fimmu.2022.933847/fullMDSCpharmacotherapyimmune suppressionimmunomodulationinflammation |
| spellingShingle | Chiel van Geffen Constantin Heiss Astrid Deißler Saeed Kolahian Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation Frontiers in Immunology MDSC pharmacotherapy immune suppression immunomodulation inflammation |
| title | Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation |
| title_full | Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation |
| title_fullStr | Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation |
| title_full_unstemmed | Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation |
| title_short | Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation |
| title_sort | pharmacological modulation of myeloid derived suppressor cells to dampen inflammation |
| topic | MDSC pharmacotherapy immune suppression immunomodulation inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.933847/full |
| work_keys_str_mv | AT chielvangeffen pharmacologicalmodulationofmyeloidderivedsuppressorcellstodampeninflammation AT constantinheiss pharmacologicalmodulationofmyeloidderivedsuppressorcellstodampeninflammation AT astriddeißler pharmacologicalmodulationofmyeloidderivedsuppressorcellstodampeninflammation AT saeedkolahian pharmacologicalmodulationofmyeloidderivedsuppressorcellstodampeninflammation |