Branched Linkers for Site-Specific Fluorescent Labeling of Antibodies

Branched Linkers for Site-Specific Fluorescent Labeling of Antibodies

Fluorescent antibodies have proved to be an invaluable tool for molecular biology and diagnostics. They are routinely produced by modification of lysine residues, which leads to high heterogeneity. As such, their affinity may be compromised if the antigen-binding site is affected, the probability of...

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Bibliographic Details
Main Authors: Ksenia A. Sapozhnikova, Evgeny L. Gulyak, Vsevolod A. Misyurin, Maria A. Simonova, Ekaterina V. Ryabukhina, Anastasiya V. Alexeeva, Nataliya A. Tikhonova, Natalia A. Lyzhko, Galina P. Popova, Andrey V. Misyurin, Alexey V. Ustinov, Vladimir A. Korshun, Vera A. Alferova, Dmitry Yu. Ryazantsev, Vladimir A. Brylev
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
fluorescent antibody
branched linkers
FRET
degree of labeling
periodate oxidation
immunoglobulin G
Online Access:https://www.mdpi.com/1420-3049/28/1/425

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https://www.mdpi.com/1420-3049/28/1/425

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