Long Non-coding RNA HIX003209 Promotes Inflammation by Sponging miR-6089 via TLR4/NF-κB Signaling Pathway in Rheumatoid Arthritis
Accumulating studies have suggested that long non-coding RNAs (lncRNAs) have drawn more and more attention in rheumatoid arthritis (RA), which can function as competitive endogenous RNAs (ceRNAs) in inflammation and immune disorders. Previously, we have found that lncRNA HIX003209 is differentially...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.02218/full |
| _version_ | 1811299815958511616 |
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| author | Shushan Yan Shushan Yan Pingping Wang Jinghua Wang Jinghua Wang Jinghan Yang Jinghan Yang Hongying Lu Chengwen Jin Min Cheng Donghua Xu Donghua Xu |
| author_facet | Shushan Yan Shushan Yan Pingping Wang Jinghua Wang Jinghua Wang Jinghan Yang Jinghan Yang Hongying Lu Chengwen Jin Min Cheng Donghua Xu Donghua Xu |
| author_sort | Shushan Yan |
| collection | DOAJ |
| description | Accumulating studies have suggested that long non-coding RNAs (lncRNAs) have drawn more and more attention in rheumatoid arthritis (RA), which can function as competitive endogenous RNAs (ceRNAs) in inflammation and immune disorders. Previously, we have found that lncRNA HIX003209 is differentially expressed in RA. However, the precise mechanism of lncRNA HIX003209 in RA is still vague. We aim to elucidate the role and its targeted microRNA of lncRNA HIX003209 in RA as ceRNA. Significantly increased expression of lncRNA HIX003209 was observed in the peripheral blood mononuclear cells (PBMCs) from RA cases. It was positively associated with TLR2 and TLR4 in RA. Besides, peptidoglycan (PGN) and lipopolysaccharide (LPS) could enhance the expression of lncRNA HIX003209, which reversely promoted the proliferation and activation of macrophages through IκBα/NF-κB signaling pathway. Moreover, HIX003209 was involved in TLR4-mediated inflammation via targeting miR-6089 in macrophages. LncRNA HIX003209 functions as a ceRNA and exaggerates inflammation by sponging miR-6089 through TLR4/NF-κB pathway in macrophages, which offers promising therapeutic strategies for RA. |
| first_indexed | 2024-04-13T06:42:22Z |
| format | Article |
| id | doaj.art-b462204da65d4216b3cd2202181ec6ae |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T06:42:22Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Immunology |
| spelling | doaj.art-b462204da65d4216b3cd2202181ec6ae2022-12-22T02:57:42ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-09-011010.3389/fimmu.2019.02218472716Long Non-coding RNA HIX003209 Promotes Inflammation by Sponging miR-6089 via TLR4/NF-κB Signaling Pathway in Rheumatoid ArthritisShushan Yan0Shushan Yan1Pingping Wang2Jinghua Wang3Jinghua Wang4Jinghan Yang5Jinghan Yang6Hongying Lu7Chengwen Jin8Min Cheng9Donghua Xu10Donghua Xu11Clinical Medicine College, Weifang Medical University, Weifang, ChinaDepartment of Gastrointestinal and Anal Diseases Surgery, The Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Gynecology and Obstetrics, Weifang Hospital of Maternal and Child Health, Weifang, ChinaClinical Medicine College, Weifang Medical University, Weifang, ChinaDepartment of Rheumatology, The Affiliated Hospital of Weifang Medical University, Weifang, ChinaClinical Medicine College, Weifang Medical University, Weifang, ChinaDepartment of Rheumatology, The Affiliated Hospital of Weifang Medical University, Weifang, ChinaFunctional Laboratory, Clinical Medicine College of Weifang Medical University, Weifang, ChinaFunctional Laboratory, Clinical Medicine College of Weifang Medical University, Weifang, ChinaDepartment of Physiology, Weifang Medical University, Weifang, ChinaClinical Medicine College, Weifang Medical University, Weifang, ChinaDepartment of Rheumatology, The Affiliated Hospital of Weifang Medical University, Weifang, ChinaAccumulating studies have suggested that long non-coding RNAs (lncRNAs) have drawn more and more attention in rheumatoid arthritis (RA), which can function as competitive endogenous RNAs (ceRNAs) in inflammation and immune disorders. Previously, we have found that lncRNA HIX003209 is differentially expressed in RA. However, the precise mechanism of lncRNA HIX003209 in RA is still vague. We aim to elucidate the role and its targeted microRNA of lncRNA HIX003209 in RA as ceRNA. Significantly increased expression of lncRNA HIX003209 was observed in the peripheral blood mononuclear cells (PBMCs) from RA cases. It was positively associated with TLR2 and TLR4 in RA. Besides, peptidoglycan (PGN) and lipopolysaccharide (LPS) could enhance the expression of lncRNA HIX003209, which reversely promoted the proliferation and activation of macrophages through IκBα/NF-κB signaling pathway. Moreover, HIX003209 was involved in TLR4-mediated inflammation via targeting miR-6089 in macrophages. LncRNA HIX003209 functions as a ceRNA and exaggerates inflammation by sponging miR-6089 through TLR4/NF-κB pathway in macrophages, which offers promising therapeutic strategies for RA.https://www.frontiersin.org/article/10.3389/fimmu.2019.02218/fulllong non-coding RNAcompetitive endogenous RNAmiRNAinflammationtoll-like receptorNF-κB |
| spellingShingle | Shushan Yan Shushan Yan Pingping Wang Jinghua Wang Jinghua Wang Jinghan Yang Jinghan Yang Hongying Lu Chengwen Jin Min Cheng Donghua Xu Donghua Xu Long Non-coding RNA HIX003209 Promotes Inflammation by Sponging miR-6089 via TLR4/NF-κB Signaling Pathway in Rheumatoid Arthritis Frontiers in Immunology long non-coding RNA competitive endogenous RNA miRNA inflammation toll-like receptor NF-κB |
| title | Long Non-coding RNA HIX003209 Promotes Inflammation by Sponging miR-6089 via TLR4/NF-κB Signaling Pathway in Rheumatoid Arthritis |
| title_full | Long Non-coding RNA HIX003209 Promotes Inflammation by Sponging miR-6089 via TLR4/NF-κB Signaling Pathway in Rheumatoid Arthritis |
| title_fullStr | Long Non-coding RNA HIX003209 Promotes Inflammation by Sponging miR-6089 via TLR4/NF-κB Signaling Pathway in Rheumatoid Arthritis |
| title_full_unstemmed | Long Non-coding RNA HIX003209 Promotes Inflammation by Sponging miR-6089 via TLR4/NF-κB Signaling Pathway in Rheumatoid Arthritis |
| title_short | Long Non-coding RNA HIX003209 Promotes Inflammation by Sponging miR-6089 via TLR4/NF-κB Signaling Pathway in Rheumatoid Arthritis |
| title_sort | long non coding rna hix003209 promotes inflammation by sponging mir 6089 via tlr4 nf κb signaling pathway in rheumatoid arthritis |
| topic | long non-coding RNA competitive endogenous RNA miRNA inflammation toll-like receptor NF-κB |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.02218/full |
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