Multi Targeted CAR-T Cell Therapies for B-Cell Malignancies
Chimeric antigen receptor (CAR) modified T cell therapy has revolutionized the treatment of relapsed and refractory hematological malignancies. Through targeting of the CD19 antigen on B cells durable remissions have been achieved in patients with B cell non-Hodgkin lymphoma and acute lymphoblastic...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2019.00146/full |
| _version_ | 1819330599897268224 |
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| author | Nirav N. Shah Theresa Maatman Parameswaran Hari Bryon Johnson |
| author_facet | Nirav N. Shah Theresa Maatman Parameswaran Hari Bryon Johnson |
| author_sort | Nirav N. Shah |
| collection | DOAJ |
| description | Chimeric antigen receptor (CAR) modified T cell therapy has revolutionized the treatment of relapsed and refractory hematological malignancies. Through targeting of the CD19 antigen on B cells durable remissions have been achieved in patients with B cell non-Hodgkin lymphoma and acute lymphoblastic lymphoma. Despite impressive responses, multiple escape mechanisms to evade CAR-T cell therapy have been identified, among which the most common is loss of the target antigen. In this review we will highlight outcomes to date with CD19 CAR-T cell therapy, describe the current limitations of single targeted CAR-T therapies, review identified tumor escape mechanisms, and lastly discuss novel strategies to overcome resistance via multi-targeted CAR-T cells. |
| first_indexed | 2024-12-24T14:01:06Z |
| format | Article |
| id | doaj.art-b46498c06ef947a9956d25789354b9ea |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-24T14:01:06Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-b46498c06ef947a9956d25789354b9ea2022-12-21T16:52:28ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2019-03-01910.3389/fonc.2019.00146436920Multi Targeted CAR-T Cell Therapies for B-Cell MalignanciesNirav N. Shah0Theresa Maatman1Parameswaran Hari2Bryon Johnson3Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, United StatesDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI, United StatesDivision of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, United StatesDivision of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, United StatesChimeric antigen receptor (CAR) modified T cell therapy has revolutionized the treatment of relapsed and refractory hematological malignancies. Through targeting of the CD19 antigen on B cells durable remissions have been achieved in patients with B cell non-Hodgkin lymphoma and acute lymphoblastic lymphoma. Despite impressive responses, multiple escape mechanisms to evade CAR-T cell therapy have been identified, among which the most common is loss of the target antigen. In this review we will highlight outcomes to date with CD19 CAR-T cell therapy, describe the current limitations of single targeted CAR-T therapies, review identified tumor escape mechanisms, and lastly discuss novel strategies to overcome resistance via multi-targeted CAR-T cells.https://www.frontiersin.org/article/10.3389/fonc.2019.00146/fullCAR-Tantigen escapeB-cell NHLB-cell ALLimmunotherapy |
| spellingShingle | Nirav N. Shah Theresa Maatman Parameswaran Hari Bryon Johnson Multi Targeted CAR-T Cell Therapies for B-Cell Malignancies Frontiers in Oncology CAR-T antigen escape B-cell NHL B-cell ALL immunotherapy |
| title | Multi Targeted CAR-T Cell Therapies for B-Cell Malignancies |
| title_full | Multi Targeted CAR-T Cell Therapies for B-Cell Malignancies |
| title_fullStr | Multi Targeted CAR-T Cell Therapies for B-Cell Malignancies |
| title_full_unstemmed | Multi Targeted CAR-T Cell Therapies for B-Cell Malignancies |
| title_short | Multi Targeted CAR-T Cell Therapies for B-Cell Malignancies |
| title_sort | multi targeted car t cell therapies for b cell malignancies |
| topic | CAR-T antigen escape B-cell NHL B-cell ALL immunotherapy |
| url | https://www.frontiersin.org/article/10.3389/fonc.2019.00146/full |
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