The role of platelet function analyzer-200 in predicting perioperative bleeding risk
Background/Aims Various preoperative screening tests, such as platelet count, prothrombin time, activated partial thromboplastin time, and bleeding time, have been widely used to evaluate the risk of bleeding during surgery. Use of platelet function analyzer (PFA)-100/200 for assessing platelet func...
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| Format: | Article |
| Language: | English |
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The Korean Association of Internal Medicine
2020-09-01
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| Series: | The Korean Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://www.kjim.org/upload/pdf/kjim-2019-112.pdf |
| _version_ | 1818425960151646208 |
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| author | Eun Sang Yu Min Ji Jeon Ka-Won Kang Byung-Hyun Lee Eun Joo Kang Yong Park Se Ryeon Lee Hwa Jung Sung Chul Won Choi Byung Soo Kim Dae Sik Kim |
| author_facet | Eun Sang Yu Min Ji Jeon Ka-Won Kang Byung-Hyun Lee Eun Joo Kang Yong Park Se Ryeon Lee Hwa Jung Sung Chul Won Choi Byung Soo Kim Dae Sik Kim |
| author_sort | Eun Sang Yu |
| collection | DOAJ |
| description | Background/Aims Various preoperative screening tests, such as platelet count, prothrombin time, activated partial thromboplastin time, and bleeding time, have been widely used to evaluate the risk of bleeding during surgery. Use of platelet function analyzer (PFA)-100/200 for assessing platelet function instead of bleeding time is increasing. However, its role in predicting the perioperative risk of bleeding remains controversial. Methods Data of 703 patients who underwent surgery under general anesthesia were retrospectively analyzed. Preoperative platelet function was measured using PFA-200 system and the association with intraoperative bleeding was assessed. Additionally, other variables that could affect PFA-200 results were assessed by logistic regression analysis. Results Collagen/epinephrine (COL/EPI) test was prolonged in 199/703 (28.3%) patients (EPI group), while 99/212 (46.7%) patients showed COL/adenosine diphosphate test abnormalities. Bleeding over 300 mL during surgery occurred in 14.3% and 20.1% of patients in the normal and EPI groups, respectively (p = 0.058). In addition, red blood cell transfusion within 72 hours after surgery rate was significantly higher in the EPI group than in the normal group (31.7% vs. 23.4%, p = 0.024). In multivariate logistic analysis, prolongation closure time with COL/EPI (p = 0.068) was marginally associated with risk of bleeding during surgery. Furthermore, PFA-200 results were influenced by various factors, such as nonsteroidal anti-inflammatory drug use, blood group, hematocrit, and time of blood collection. Conclusions Preoperative PFA-200 test may be helpful in predicting the risk of perioperative bleeding. However, its results should be carefully interpreted because they are affected by several factors. |
| first_indexed | 2024-12-14T14:22:14Z |
| format | Article |
| id | doaj.art-b464a28a971f43efa080d5da0d5c97fc |
| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-12-14T14:22:14Z |
| publishDate | 2020-09-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-b464a28a971f43efa080d5da0d5c97fc2022-12-21T22:58:03ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482020-09-013551199120910.3904/kjim.2019.112170300The role of platelet function analyzer-200 in predicting perioperative bleeding riskEun Sang Yu0Min Ji Jeon1Ka-Won Kang2Byung-Hyun Lee3Eun Joo Kang4Yong Park5Se Ryeon Lee6Hwa Jung Sung7Chul Won Choi8Byung Soo Kim9Dae Sik Kim10 Division of Hematology-Oncology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea Division of Hematology-Oncology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea Division of Hematology-Oncology, Department of Internal Medicine, Korea University Anam Hospital, Seoul, Korea Division of Hematology-Oncology, Department of Internal Medicine, Korea University Anam Hospital, Seoul, Korea Division of Hematology-Oncology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea Division of Hematology-Oncology, Department of Internal Medicine, Korea University Anam Hospital, Seoul, Korea Division of Hematology-Oncology, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Korea Division of Hematology-Oncology, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Korea Division of Hematology-Oncology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea Division of Hematology-Oncology, Department of Internal Medicine, Korea University Anam Hospital, Seoul, Korea Division of Hematology-Oncology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, KoreaBackground/Aims Various preoperative screening tests, such as platelet count, prothrombin time, activated partial thromboplastin time, and bleeding time, have been widely used to evaluate the risk of bleeding during surgery. Use of platelet function analyzer (PFA)-100/200 for assessing platelet function instead of bleeding time is increasing. However, its role in predicting the perioperative risk of bleeding remains controversial. Methods Data of 703 patients who underwent surgery under general anesthesia were retrospectively analyzed. Preoperative platelet function was measured using PFA-200 system and the association with intraoperative bleeding was assessed. Additionally, other variables that could affect PFA-200 results were assessed by logistic regression analysis. Results Collagen/epinephrine (COL/EPI) test was prolonged in 199/703 (28.3%) patients (EPI group), while 99/212 (46.7%) patients showed COL/adenosine diphosphate test abnormalities. Bleeding over 300 mL during surgery occurred in 14.3% and 20.1% of patients in the normal and EPI groups, respectively (p = 0.058). In addition, red blood cell transfusion within 72 hours after surgery rate was significantly higher in the EPI group than in the normal group (31.7% vs. 23.4%, p = 0.024). In multivariate logistic analysis, prolongation closure time with COL/EPI (p = 0.068) was marginally associated with risk of bleeding during surgery. Furthermore, PFA-200 results were influenced by various factors, such as nonsteroidal anti-inflammatory drug use, blood group, hematocrit, and time of blood collection. Conclusions Preoperative PFA-200 test may be helpful in predicting the risk of perioperative bleeding. However, its results should be carefully interpreted because they are affected by several factors.http://www.kjim.org/upload/pdf/kjim-2019-112.pdfplatelet function analyzerbleedingsurgeryscreening test |
| spellingShingle | Eun Sang Yu Min Ji Jeon Ka-Won Kang Byung-Hyun Lee Eun Joo Kang Yong Park Se Ryeon Lee Hwa Jung Sung Chul Won Choi Byung Soo Kim Dae Sik Kim The role of platelet function analyzer-200 in predicting perioperative bleeding risk The Korean Journal of Internal Medicine platelet function analyzer bleeding surgery screening test |
| title | The role of platelet function analyzer-200 in predicting perioperative bleeding risk |
| title_full | The role of platelet function analyzer-200 in predicting perioperative bleeding risk |
| title_fullStr | The role of platelet function analyzer-200 in predicting perioperative bleeding risk |
| title_full_unstemmed | The role of platelet function analyzer-200 in predicting perioperative bleeding risk |
| title_short | The role of platelet function analyzer-200 in predicting perioperative bleeding risk |
| title_sort | role of platelet function analyzer 200 in predicting perioperative bleeding risk |
| topic | platelet function analyzer bleeding surgery screening test |
| url | http://www.kjim.org/upload/pdf/kjim-2019-112.pdf |
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