Statin use and the risk of ovarian and endometrial cancers: a meta-analysis
Abstract Background The relationship between statin use and the risk of ovarian or endometrial cancer remains controversial. Here, we investigated the relationship between statin use and the risk of ovarian and endometrial cancers. Methods We conducted a meta-analysis using articles retrieved from t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-07-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-019-5954-0 |
| _version_ | 1818528800112115712 |
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| author | Yizi Wang Fang Ren Zixuan Song Peng Chen Shuang Liu Ling Ouyang |
| author_facet | Yizi Wang Fang Ren Zixuan Song Peng Chen Shuang Liu Ling Ouyang |
| author_sort | Yizi Wang |
| collection | DOAJ |
| description | Abstract Background The relationship between statin use and the risk of ovarian or endometrial cancer remains controversial. Here, we investigated the relationship between statin use and the risk of ovarian and endometrial cancers. Methods We conducted a meta-analysis using articles retrieved from the PubMed, Embase, and Web of Science databases. All original comparative studies published in English that were related to statin use and the risk of ovarian or endometrial cancer were included. Results This meta-analysis included 19 studies enrolling 1,999,362 female subjects and 19,849 cancer cases (7,948 ovarian cancer cases and 11,901 endometrial cancer cases). The overall analysis indicated that statin use did not significantly reduce the risk of ovarian cancer [relative risk (RR) = 0.88, 95% confidence interval (CI) 0.76–1.03, p = 0.12] or the risk of endometrial cancer (RR = 0.88, 95% CI 0.78–1.00, p = 0.05.) Subgroup analyses based on study type, percentage of cancer cases, study location, and quality of studies also supported our conclusions. No association was found between long-term statin use (> 5 years) and the risk of ovarian cancer (RR = 0.73, 95% CI 0.51–1.04, p = 0.08) or endometrial cancer (RR = 0.79, 95% CI 0.58–1.08, p = 0.14). Conclusions Statin use did not lower the risk of ovarian cancer or endometrial cancer. The long-term use of statins (> 5 years) was not associated with a reduction in the risk of ovarian or endometrial cancer. |
| first_indexed | 2024-12-11T06:54:43Z |
| format | Article |
| id | doaj.art-b464b0f22a8843ef989d703cbc4949cb |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-11T06:54:43Z |
| publishDate | 2019-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-b464b0f22a8843ef989d703cbc4949cb2022-12-22T01:16:48ZengBMCBMC Cancer1471-24072019-07-0119111010.1186/s12885-019-5954-0Statin use and the risk of ovarian and endometrial cancers: a meta-analysisYizi Wang0Fang Ren1Zixuan Song2Peng Chen3Shuang Liu4Ling Ouyang5Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical UniversityDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical UniversityDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical UniversityDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical UniversityDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical UniversityDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical UniversityAbstract Background The relationship between statin use and the risk of ovarian or endometrial cancer remains controversial. Here, we investigated the relationship between statin use and the risk of ovarian and endometrial cancers. Methods We conducted a meta-analysis using articles retrieved from the PubMed, Embase, and Web of Science databases. All original comparative studies published in English that were related to statin use and the risk of ovarian or endometrial cancer were included. Results This meta-analysis included 19 studies enrolling 1,999,362 female subjects and 19,849 cancer cases (7,948 ovarian cancer cases and 11,901 endometrial cancer cases). The overall analysis indicated that statin use did not significantly reduce the risk of ovarian cancer [relative risk (RR) = 0.88, 95% confidence interval (CI) 0.76–1.03, p = 0.12] or the risk of endometrial cancer (RR = 0.88, 95% CI 0.78–1.00, p = 0.05.) Subgroup analyses based on study type, percentage of cancer cases, study location, and quality of studies also supported our conclusions. No association was found between long-term statin use (> 5 years) and the risk of ovarian cancer (RR = 0.73, 95% CI 0.51–1.04, p = 0.08) or endometrial cancer (RR = 0.79, 95% CI 0.58–1.08, p = 0.14). Conclusions Statin use did not lower the risk of ovarian cancer or endometrial cancer. The long-term use of statins (> 5 years) was not associated with a reduction in the risk of ovarian or endometrial cancer.http://link.springer.com/article/10.1186/s12885-019-5954-0StatinOvarian cancerEndometrial cancer |
| spellingShingle | Yizi Wang Fang Ren Zixuan Song Peng Chen Shuang Liu Ling Ouyang Statin use and the risk of ovarian and endometrial cancers: a meta-analysis BMC Cancer Statin Ovarian cancer Endometrial cancer |
| title | Statin use and the risk of ovarian and endometrial cancers: a meta-analysis |
| title_full | Statin use and the risk of ovarian and endometrial cancers: a meta-analysis |
| title_fullStr | Statin use and the risk of ovarian and endometrial cancers: a meta-analysis |
| title_full_unstemmed | Statin use and the risk of ovarian and endometrial cancers: a meta-analysis |
| title_short | Statin use and the risk of ovarian and endometrial cancers: a meta-analysis |
| title_sort | statin use and the risk of ovarian and endometrial cancers a meta analysis |
| topic | Statin Ovarian cancer Endometrial cancer |
| url | http://link.springer.com/article/10.1186/s12885-019-5954-0 |
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