Balanced Chromosomal Rearrangements Associated with Hypoprolificacy in Australian Boars (<i>Sus scrofa domesticus</i>)
Balanced chromosomal rearrangements, mainly reciprocal translocations, are considered to be the causative agent of several clinical conditions in farmed pigs, resulting in hypoprolificacy and economic losses. Literature suggests that reciprocal translocations are heritable and can occur de novo. The...
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MDPI AG
2021-08-01
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| Online Access: | https://www.mdpi.com/2073-4409/10/8/2000 |
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| author | Foyez Shams Darryl D’Souza Tariq Ezaz |
| author_facet | Foyez Shams Darryl D’Souza Tariq Ezaz |
| author_sort | Foyez Shams |
| collection | DOAJ |
| description | Balanced chromosomal rearrangements, mainly reciprocal translocations, are considered to be the causative agent of several clinical conditions in farmed pigs, resulting in hypoprolificacy and economic losses. Literature suggests that reciprocal translocations are heritable and can occur de novo. The prevalence rate of these balanced structural rearrangements of chromosomes differs from country to country and varies between 0.5% and 3.3%. The Australian pig population is descendent of a small founder population and has since been a closed genetic group since the 1980s. Hence, any incident of reciprocal translocation along with the pedigree of boars that contribute sperm for artificial insemination has the potential to have an economic consequence. To date, there has been no published account for screening of reciprocal translocation associated with hypoprolificacy in the Australian pig population. In this study, we performed standard and molecular cytogenetic analyses to identify evidence of chromosome rearrangements and their association with hypoprolificacy in a representative 94 boar samples from a commercial nucleus herd. We identified three novel rearrangements between chromosomes 5 and 14, between chromosomes 9 and 10, and between chromosomes 10 and 12. In addition, we also detected a reciprocal translocation between chromosomes 3 and 16 that has previously been detected in pig herds in France. The prevalence rate was 6.38% within the samples used in this study. All four rearrangements were found to have an association with hypoprolificacy. Further study and routine monitoring will be necessary to identify any further rearrangements that will allow breeders to prevent the propagation of reciprocal translocations from generation to generation within the Australian pig population. |
| first_indexed | 2024-03-10T08:55:48Z |
| format | Article |
| id | doaj.art-b464fb9ea74c4f1cbccad08b6fe3edfb |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T08:55:48Z |
| publishDate | 2021-08-01 |
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| spelling | doaj.art-b464fb9ea74c4f1cbccad08b6fe3edfb2023-11-22T07:10:19ZengMDPI AGCells2073-44092021-08-01108200010.3390/cells10082000Balanced Chromosomal Rearrangements Associated with Hypoprolificacy in Australian Boars (<i>Sus scrofa domesticus</i>)Foyez Shams0Darryl D’Souza1Tariq Ezaz2Centre for Conservation Ecology and Genomics, Institute for Applied Ecology, Faculty of Science and Technology, University of Canberra, Bruce, ACT 2617, AustraliaSunPork Group, Eagle Farm, QLD 4009, AustraliaCentre for Conservation Ecology and Genomics, Institute for Applied Ecology, Faculty of Science and Technology, University of Canberra, Bruce, ACT 2617, AustraliaBalanced chromosomal rearrangements, mainly reciprocal translocations, are considered to be the causative agent of several clinical conditions in farmed pigs, resulting in hypoprolificacy and economic losses. Literature suggests that reciprocal translocations are heritable and can occur de novo. The prevalence rate of these balanced structural rearrangements of chromosomes differs from country to country and varies between 0.5% and 3.3%. The Australian pig population is descendent of a small founder population and has since been a closed genetic group since the 1980s. Hence, any incident of reciprocal translocation along with the pedigree of boars that contribute sperm for artificial insemination has the potential to have an economic consequence. To date, there has been no published account for screening of reciprocal translocation associated with hypoprolificacy in the Australian pig population. In this study, we performed standard and molecular cytogenetic analyses to identify evidence of chromosome rearrangements and their association with hypoprolificacy in a representative 94 boar samples from a commercial nucleus herd. We identified three novel rearrangements between chromosomes 5 and 14, between chromosomes 9 and 10, and between chromosomes 10 and 12. In addition, we also detected a reciprocal translocation between chromosomes 3 and 16 that has previously been detected in pig herds in France. The prevalence rate was 6.38% within the samples used in this study. All four rearrangements were found to have an association with hypoprolificacy. Further study and routine monitoring will be necessary to identify any further rearrangements that will allow breeders to prevent the propagation of reciprocal translocations from generation to generation within the Australian pig population.https://www.mdpi.com/2073-4409/10/8/2000chromosomekaryotypetranslocationpigreproductive performanceFISH |
| spellingShingle | Foyez Shams Darryl D’Souza Tariq Ezaz Balanced Chromosomal Rearrangements Associated with Hypoprolificacy in Australian Boars (<i>Sus scrofa domesticus</i>) Cells chromosome karyotype translocation pig reproductive performance FISH |
| title | Balanced Chromosomal Rearrangements Associated with Hypoprolificacy in Australian Boars (<i>Sus scrofa domesticus</i>) |
| title_full | Balanced Chromosomal Rearrangements Associated with Hypoprolificacy in Australian Boars (<i>Sus scrofa domesticus</i>) |
| title_fullStr | Balanced Chromosomal Rearrangements Associated with Hypoprolificacy in Australian Boars (<i>Sus scrofa domesticus</i>) |
| title_full_unstemmed | Balanced Chromosomal Rearrangements Associated with Hypoprolificacy in Australian Boars (<i>Sus scrofa domesticus</i>) |
| title_short | Balanced Chromosomal Rearrangements Associated with Hypoprolificacy in Australian Boars (<i>Sus scrofa domesticus</i>) |
| title_sort | balanced chromosomal rearrangements associated with hypoprolificacy in australian boars i sus scrofa domesticus i |
| topic | chromosome karyotype translocation pig reproductive performance FISH |
| url | https://www.mdpi.com/2073-4409/10/8/2000 |
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