Field effect transistor based wearable biosensors for healthcare monitoring
Abstract The rapid advancement of wearable biosensors has revolutionized healthcare monitoring by screening in a non-invasive and continuous manner. Among various sensing techniques, field-effect transistor (FET)-based wearable biosensors attract increasing attention due to their advantages such as...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-023-02153-1 |
| _version_ | 1797629975491248128 |
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| author | Thi Thanh-Ha Nguyen Cong Minh Nguyen Minh Anh Huynh Hoang Huy Vu Tuan-Khoa Nguyen Nam-Trung Nguyen |
| author_facet | Thi Thanh-Ha Nguyen Cong Minh Nguyen Minh Anh Huynh Hoang Huy Vu Tuan-Khoa Nguyen Nam-Trung Nguyen |
| author_sort | Thi Thanh-Ha Nguyen |
| collection | DOAJ |
| description | Abstract The rapid advancement of wearable biosensors has revolutionized healthcare monitoring by screening in a non-invasive and continuous manner. Among various sensing techniques, field-effect transistor (FET)-based wearable biosensors attract increasing attention due to their advantages such as label-free detection, fast response, easy operation, and capability of integration. This review explores the innovative developments and applications of FET-based wearable biosensors for healthcare monitoring. Beginning with an introduction to the significance of wearable biosensors, the paper gives an overview of structural and operational principles of FETs, providing insights into their diverse classifications. Next, the paper discusses the fabrication methods, semiconductor surface modification techniques and gate surface functionalization strategies. This background lays the foundation for exploring specific FET-based biosensor designs, including enzyme, antibody and nanobody, aptamer, as well as ion-sensitive membrane sensors. Subsequently, the paper investigates the incorporation of FET-based biosensors in monitoring biomarkers present in physiological fluids such as sweat, tears, saliva, and skin interstitial fluid (ISF). Finally, we address challenges, technical issues, and opportunities related to FET-based biosensor applications. This comprehensive review underscores the transformative potential of FET-based wearable biosensors in healthcare monitoring. By offering a multidimensional perspective on device design, fabrication, functionalization and applications, this paper aims to serve as a valuable resource for researchers in the field of biosensing technology and personalized healthcare. |
| first_indexed | 2024-03-11T11:01:27Z |
| format | Article |
| id | doaj.art-b4672b6998ad42e8b582ba011bd3934a |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-03-11T11:01:27Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-b4672b6998ad42e8b582ba011bd3934a2023-11-12T12:29:09ZengBMCJournal of Nanobiotechnology1477-31552023-11-0121112910.1186/s12951-023-02153-1Field effect transistor based wearable biosensors for healthcare monitoringThi Thanh-Ha Nguyen0Cong Minh Nguyen1Minh Anh Huynh2Hoang Huy Vu3Tuan-Khoa Nguyen4Nam-Trung Nguyen5Queensland Micro- and Nanotechnology Centre, Griffith UniversityQueensland Micro- and Nanotechnology Centre, Griffith UniversityQueensland Micro- and Nanotechnology Centre, Griffith UniversityQueensland Micro- and Nanotechnology Centre, Griffith UniversityQueensland Micro- and Nanotechnology Centre, Griffith UniversityQueensland Micro- and Nanotechnology Centre, Griffith UniversityAbstract The rapid advancement of wearable biosensors has revolutionized healthcare monitoring by screening in a non-invasive and continuous manner. Among various sensing techniques, field-effect transistor (FET)-based wearable biosensors attract increasing attention due to their advantages such as label-free detection, fast response, easy operation, and capability of integration. This review explores the innovative developments and applications of FET-based wearable biosensors for healthcare monitoring. Beginning with an introduction to the significance of wearable biosensors, the paper gives an overview of structural and operational principles of FETs, providing insights into their diverse classifications. Next, the paper discusses the fabrication methods, semiconductor surface modification techniques and gate surface functionalization strategies. This background lays the foundation for exploring specific FET-based biosensor designs, including enzyme, antibody and nanobody, aptamer, as well as ion-sensitive membrane sensors. Subsequently, the paper investigates the incorporation of FET-based biosensors in monitoring biomarkers present in physiological fluids such as sweat, tears, saliva, and skin interstitial fluid (ISF). Finally, we address challenges, technical issues, and opportunities related to FET-based biosensor applications. This comprehensive review underscores the transformative potential of FET-based wearable biosensors in healthcare monitoring. By offering a multidimensional perspective on device design, fabrication, functionalization and applications, this paper aims to serve as a valuable resource for researchers in the field of biosensing technology and personalized healthcare.https://doi.org/10.1186/s12951-023-02153-1Field effect transistorbioFETWearable deviceBiosensorNon-invasive monitoringSweat |
| spellingShingle | Thi Thanh-Ha Nguyen Cong Minh Nguyen Minh Anh Huynh Hoang Huy Vu Tuan-Khoa Nguyen Nam-Trung Nguyen Field effect transistor based wearable biosensors for healthcare monitoring Journal of Nanobiotechnology Field effect transistor bioFET Wearable device Biosensor Non-invasive monitoring Sweat |
| title | Field effect transistor based wearable biosensors for healthcare monitoring |
| title_full | Field effect transistor based wearable biosensors for healthcare monitoring |
| title_fullStr | Field effect transistor based wearable biosensors for healthcare monitoring |
| title_full_unstemmed | Field effect transistor based wearable biosensors for healthcare monitoring |
| title_short | Field effect transistor based wearable biosensors for healthcare monitoring |
| title_sort | field effect transistor based wearable biosensors for healthcare monitoring |
| topic | Field effect transistor bioFET Wearable device Biosensor Non-invasive monitoring Sweat |
| url | https://doi.org/10.1186/s12951-023-02153-1 |
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