Determination of biochemical indicators when modeling HIPEC with cisplatin on rats
HIPEC (Hyperthermic intraperitoneal chemotherapy; hyperthermic intraoperative intraperitoneally chemoperfusion) is a method of treating primary and secondary peritoneal tumors. Perfusion of the peritoneal cavity with solutions with cytotoxic agents at a temperature above the physiological norm (41-4...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2019-03-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | http://www.ojs.ukw.edu.pl/index.php/johs/article/view/7143 |
| _version_ | 1819084140961595392 |
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| author | E. D. Pykhtieieva A. M. Tretyakov A. I. Gozhenko E. G. Pykhtieieva |
| author_facet | E. D. Pykhtieieva A. M. Tretyakov A. I. Gozhenko E. G. Pykhtieieva |
| author_sort | E. D. Pykhtieieva |
| collection | DOAJ |
| description | HIPEC (Hyperthermic intraperitoneal chemotherapy; hyperthermic intraoperative intraperitoneally chemoperfusion) is a method of treating primary and secondary peritoneal tumors. Perfusion of the peritoneal cavity with solutions with cytotoxic agents at a temperature above the physiological norm (41-43 ° C) occurs when HIPEC. The conducted biochemical studies suggest that with HIPEC, elevated temperature is an important factor and leads to potentiation of the toxic effect of cisplatin. Despite the higher accumulation of platinum in the kidneys during cold solution perfusion, the resulting change in biochemical parameters is higher with the simultaneous action of elevated temperature and cisplatin. |
| first_indexed | 2024-12-21T20:43:44Z |
| format | Article |
| id | doaj.art-b468caf6f1d647e980aa26bac027109f |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-12-21T20:43:44Z |
| publishDate | 2019-03-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-b468caf6f1d647e980aa26bac027109f2022-12-21T18:50:54ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062019-03-019362663110.5281/zenodo.33090346323Determination of biochemical indicators when modeling HIPEC with cisplatin on ratsE. D. Pykhtieieva0A. M. Tretyakov1A. I. Gozhenko2E. G. Pykhtieieva3Ukrainian Research Institute of Transport MedicineUkrainian Research Institute of Transport MedicineUkrainian Research Institute of Transport MedicineUkrainian Research Institute of Transport MedicineHIPEC (Hyperthermic intraperitoneal chemotherapy; hyperthermic intraoperative intraperitoneally chemoperfusion) is a method of treating primary and secondary peritoneal tumors. Perfusion of the peritoneal cavity with solutions with cytotoxic agents at a temperature above the physiological norm (41-43 ° C) occurs when HIPEC. The conducted biochemical studies suggest that with HIPEC, elevated temperature is an important factor and leads to potentiation of the toxic effect of cisplatin. Despite the higher accumulation of platinum in the kidneys during cold solution perfusion, the resulting change in biochemical parameters is higher with the simultaneous action of elevated temperature and cisplatin.http://www.ojs.ukw.edu.pl/index.php/johs/article/view/7143ratscisplatintemperatureacid phosphataselipid peroxidationcreatinine |
| spellingShingle | E. D. Pykhtieieva A. M. Tretyakov A. I. Gozhenko E. G. Pykhtieieva Determination of biochemical indicators when modeling HIPEC with cisplatin on rats Journal of Education, Health and Sport rats cisplatin temperature acid phosphatase lipid peroxidation creatinine |
| title | Determination of biochemical indicators when modeling HIPEC with cisplatin on rats |
| title_full | Determination of biochemical indicators when modeling HIPEC with cisplatin on rats |
| title_fullStr | Determination of biochemical indicators when modeling HIPEC with cisplatin on rats |
| title_full_unstemmed | Determination of biochemical indicators when modeling HIPEC with cisplatin on rats |
| title_short | Determination of biochemical indicators when modeling HIPEC with cisplatin on rats |
| title_sort | determination of biochemical indicators when modeling hipec with cisplatin on rats |
| topic | rats cisplatin temperature acid phosphatase lipid peroxidation creatinine |
| url | http://www.ojs.ukw.edu.pl/index.php/johs/article/view/7143 |
| work_keys_str_mv | AT edpykhtieieva determinationofbiochemicalindicatorswhenmodelinghipecwithcisplatinonrats AT amtretyakov determinationofbiochemicalindicatorswhenmodelinghipecwithcisplatinonrats AT aigozhenko determinationofbiochemicalindicatorswhenmodelinghipecwithcisplatinonrats AT egpykhtieieva determinationofbiochemicalindicatorswhenmodelinghipecwithcisplatinonrats |