Retinal phototoxicity after macular hole surgery in a patient under paclitaxel
Abstract Background The purpose is to report the second case, to our knowledge, of suspected paclitaxel-induced phototoxic maculopathy following pars plana vitrectomy surgery. Case presentation 63-year-old phakic female who underwent an uneventful phaco-vitrectomy to treat a complete macular hole, d...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-08-01
|
| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-023-03086-x |
| _version_ | 1827875619533225984 |
|---|---|
| author | José M Ruiz-Moreno María García‑Zamora Jorge Ruiz‑Medrano |
| author_facet | José M Ruiz-Moreno María García‑Zamora Jorge Ruiz‑Medrano |
| author_sort | José M Ruiz-Moreno |
| collection | DOAJ |
| description | Abstract Background The purpose is to report the second case, to our knowledge, of suspected paclitaxel-induced phototoxic maculopathy following pars plana vitrectomy surgery. Case presentation 63-year-old phakic female who underwent an uneventful phaco-vitrectomy to treat a complete macular hole, developing macular phototoxicity in the post-operatively period that could not be explained by the surgery itself and could only be attributed to a possible photosensitization induced by the previous use of paclitaxel. Conclusions The use of paclitaxel has been widely extended as a chemotherapy drug to treat breast cancer. It works by altering the intracellular microtubular reorganization and, based on this mechanism of action, photosensitivity has been previously described. We report a case of suspected paclitaxel-induced macular phototoxicity following ocular endoillumination during vitrectomy surgery. |
| first_indexed | 2024-03-12T17:09:31Z |
| format | Article |
| id | doaj.art-b46b2eb8bed54900a49d1f5f1036d762 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-03-12T17:09:31Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-b46b2eb8bed54900a49d1f5f1036d7622023-08-06T11:10:10ZengBMCBMC Ophthalmology1471-24152023-08-012311710.1186/s12886-023-03086-xRetinal phototoxicity after macular hole surgery in a patient under paclitaxelJosé M Ruiz-Moreno0María García‑Zamora1Jorge Ruiz‑Medrano2Puerta de Hierro-Majadahonda University HospitalPuerta de Hierro-Majadahonda University HospitalPuerta de Hierro-Majadahonda University HospitalAbstract Background The purpose is to report the second case, to our knowledge, of suspected paclitaxel-induced phototoxic maculopathy following pars plana vitrectomy surgery. Case presentation 63-year-old phakic female who underwent an uneventful phaco-vitrectomy to treat a complete macular hole, developing macular phototoxicity in the post-operatively period that could not be explained by the surgery itself and could only be attributed to a possible photosensitization induced by the previous use of paclitaxel. Conclusions The use of paclitaxel has been widely extended as a chemotherapy drug to treat breast cancer. It works by altering the intracellular microtubular reorganization and, based on this mechanism of action, photosensitivity has been previously described. We report a case of suspected paclitaxel-induced macular phototoxicity following ocular endoillumination during vitrectomy surgery.https://doi.org/10.1186/s12886-023-03086-xMacular phototoxicityPaclitaxelVitrectomy |
| spellingShingle | José M Ruiz-Moreno María García‑Zamora Jorge Ruiz‑Medrano Retinal phototoxicity after macular hole surgery in a patient under paclitaxel BMC Ophthalmology Macular phototoxicity Paclitaxel Vitrectomy |
| title | Retinal phototoxicity after macular hole surgery in a patient under paclitaxel |
| title_full | Retinal phototoxicity after macular hole surgery in a patient under paclitaxel |
| title_fullStr | Retinal phototoxicity after macular hole surgery in a patient under paclitaxel |
| title_full_unstemmed | Retinal phototoxicity after macular hole surgery in a patient under paclitaxel |
| title_short | Retinal phototoxicity after macular hole surgery in a patient under paclitaxel |
| title_sort | retinal phototoxicity after macular hole surgery in a patient under paclitaxel |
| topic | Macular phototoxicity Paclitaxel Vitrectomy |
| url | https://doi.org/10.1186/s12886-023-03086-x |
| work_keys_str_mv | AT josemruizmoreno retinalphototoxicityaftermacularholesurgeryinapatientunderpaclitaxel AT mariagarciazamora retinalphototoxicityaftermacularholesurgeryinapatientunderpaclitaxel AT jorgeruizmedrano retinalphototoxicityaftermacularholesurgeryinapatientunderpaclitaxel |