A case of topical rapamycin effective for postsurgical hypertrophic scar of superficial lymphatic malformation with possible quality-of-life improvement
Lymphatic malformation (LM) of the body surface causes symptoms such as bleeding, pain, lymphatic leakage, or infection of the lesion, usually treated with surgical resection and sclerotherapy, with limited efficacy. The vesicles of the body surface tend to recur after surgical resection and may cau...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Journal of Dermatology and Dermatologic Surgery |
| Subjects: | |
| Online Access: | http://www.jddsjournal.org/article.asp?issn=2352-2410;year=2022;volume=26;issue=3;spage=11;epage=14;aulast=Isozaki |
| _version_ | 1798037476683546624 |
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| author | Yuki Isozaki Motoi Kato Naoko Fujita Shota Tojo Masahide Fujiki Azusa Watanabe Shoji Watanabe |
| author_facet | Yuki Isozaki Motoi Kato Naoko Fujita Shota Tojo Masahide Fujiki Azusa Watanabe Shoji Watanabe |
| author_sort | Yuki Isozaki |
| collection | DOAJ |
| description | Lymphatic malformation (LM) of the body surface causes symptoms such as bleeding, pain, lymphatic leakage, or infection of the lesion, usually treated with surgical resection and sclerotherapy, with limited efficacy. The vesicles of the body surface tend to recur after surgical resection and may cause lymphatic leakage, which could be long term a burden for patients, eventually decreasing their quality of life. In recent years, the efficacy of orally administered mammalian target of rapamycin inhibitor (rapamycin) has been reported for LM and other vascular anomalies but few are reported in the East Asian population. We report the case of a Japanese female with intractable gluteal LM that was successfully treated with topical rapamycin for postoperative recurrence and hypertrophic scarring. |
| first_indexed | 2024-04-11T21:27:04Z |
| format | Article |
| id | doaj.art-b46cf30bb85340d689715d839c388309 |
| institution | Directory Open Access Journal |
| issn | 2352-2410 2352-2429 |
| language | English |
| last_indexed | 2024-04-11T21:27:04Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Dermatology and Dermatologic Surgery |
| spelling | doaj.art-b46cf30bb85340d689715d839c3883092022-12-22T04:02:22ZengWolters Kluwer Medknow PublicationsJournal of Dermatology and Dermatologic Surgery2352-24102352-24292022-01-01263111410.4103/jdds.jdds_38_21A case of topical rapamycin effective for postsurgical hypertrophic scar of superficial lymphatic malformation with possible quality-of-life improvementYuki IsozakiMotoi KatoNaoko FujitaShota TojoMasahide FujikiAzusa WatanabeShoji WatanabeLymphatic malformation (LM) of the body surface causes symptoms such as bleeding, pain, lymphatic leakage, or infection of the lesion, usually treated with surgical resection and sclerotherapy, with limited efficacy. The vesicles of the body surface tend to recur after surgical resection and may cause lymphatic leakage, which could be long term a burden for patients, eventually decreasing their quality of life. In recent years, the efficacy of orally administered mammalian target of rapamycin inhibitor (rapamycin) has been reported for LM and other vascular anomalies but few are reported in the East Asian population. We report the case of a Japanese female with intractable gluteal LM that was successfully treated with topical rapamycin for postoperative recurrence and hypertrophic scarring.http://www.jddsjournal.org/article.asp?issn=2352-2410;year=2022;volume=26;issue=3;spage=11;epage=14;aulast=Isozakilymphatic malformationquality of liferapamycinscar/keloidtherapy (topical) |
| spellingShingle | Yuki Isozaki Motoi Kato Naoko Fujita Shota Tojo Masahide Fujiki Azusa Watanabe Shoji Watanabe A case of topical rapamycin effective for postsurgical hypertrophic scar of superficial lymphatic malformation with possible quality-of-life improvement Journal of Dermatology and Dermatologic Surgery lymphatic malformation quality of life rapamycin scar/keloid therapy (topical) |
| title | A case of topical rapamycin effective for postsurgical hypertrophic scar of superficial lymphatic malformation with possible quality-of-life improvement |
| title_full | A case of topical rapamycin effective for postsurgical hypertrophic scar of superficial lymphatic malformation with possible quality-of-life improvement |
| title_fullStr | A case of topical rapamycin effective for postsurgical hypertrophic scar of superficial lymphatic malformation with possible quality-of-life improvement |
| title_full_unstemmed | A case of topical rapamycin effective for postsurgical hypertrophic scar of superficial lymphatic malformation with possible quality-of-life improvement |
| title_short | A case of topical rapamycin effective for postsurgical hypertrophic scar of superficial lymphatic malformation with possible quality-of-life improvement |
| title_sort | case of topical rapamycin effective for postsurgical hypertrophic scar of superficial lymphatic malformation with possible quality of life improvement |
| topic | lymphatic malformation quality of life rapamycin scar/keloid therapy (topical) |
| url | http://www.jddsjournal.org/article.asp?issn=2352-2410;year=2022;volume=26;issue=3;spage=11;epage=14;aulast=Isozaki |
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