Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemia

Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemia

Abstract Cobll1 affects blast crisis (BC) progression and tyrosine kinase inhibitor (TKI) resistance in chronic myeloid leukemia (CML). PACSIN2, a novel Cobll1 binding protein, activates TKI‐induced apoptosis in K562 cells, and this activation is suppressed by Cobll1 through the interaction between...

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Bibliographic Details
Main Authors:	Kibeom Park, Hee‐Seop Yoo, Chang‐Kyu Oh, Joo Rak Lee, Hee Jin Chung, Ha‐Neul Kim, Soo‐Hyun Kim, Kyung‐Mi Kee, Tong Yoon Kim, Myungshin Kim, Byung‐Gyu Kim, Jae Sun Ra, Kyungjae Myung, Hongtae Kim, Seung Hun Han, Min‐Duk Seo, Yoonsung Lee, Dong‐Wook Kim
Format:	Article
Language:	English
Published:	Wiley 2022-11-01
Series:	Cancer Medicine
Subjects:	blastic transformation chronic myeloid leukemia Cobll1 PACSIN2 SH3BP1
Online Access:	https://doi.org/10.1002/cam4.4727

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