Prevention of Peripheral Distal Polyneuropathy in Patients with Diabetes: A Systematic Review
Background: Diabetic peripheral neuropathy (DPN) is the most frequent chronic complication and is that which generates the highest disability and mortality in diabetes mellitus (DM). As it is currently the only microvascular complication of DM without a specific treatment, prevention is essential. T...
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MDPI AG
2022-03-01
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author | Lidia Carvajal-Moreno Manuel Coheña-Jiménez Irene García-Ventura Manuel Pabón-Carrasco Ana Juana Pérez-Belloso |
author_facet | Lidia Carvajal-Moreno Manuel Coheña-Jiménez Irene García-Ventura Manuel Pabón-Carrasco Ana Juana Pérez-Belloso |
author_sort | Lidia Carvajal-Moreno |
collection | DOAJ |
description | Background: Diabetic peripheral neuropathy (DPN) is the most frequent chronic complication and is that which generates the highest disability and mortality in diabetes mellitus (DM). As it is currently the only microvascular complication of DM without a specific treatment, prevention is essential. The aim of this study was to determine the most effective preventive strategy to avoid or delay the appearance and/or development of DPN in patients with DM. Methods: A systematic search was carried out in the main health science databases (PubMed, Scopus, CINAHL, PEDro and The Cochrane Library) from 1 January 2010 to 31 August 2020. The study selection was conducted by two independent reviewers and data extraction was performed by the author. The eligibility criteria included randomized clinical trials (RCTs) and cohort studies from RCTs. Results: Eleven studies were selected that included 23,595 participants with DM. The interventions evaluated were intensive or standard glycemic control, the use of drugs to achieve glycemic control, and the promotion of a healthy lifestyle and exercise. Intensive glucose control achieved a significant reduction in the development of DPN in TIDM patients, and lifestyle modifications and exercise achieved it moderately in TIIDM patients. Conclusions: The main preventive strategy for DPN is intensive glycemic control with a target HbA1c < 6% in patients with TIDM and standard control of 7.0–7.9 in patients with TIIDM, incorporating lifestyle modifications. |
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id | doaj.art-b46f90d6c0914f688762fc6ce2984d82 |
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issn | 2077-0383 |
language | English |
last_indexed | 2024-03-09T19:36:49Z |
publishDate | 2022-03-01 |
publisher | MDPI AG |
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series | Journal of Clinical Medicine |
spelling | doaj.art-b46f90d6c0914f688762fc6ce2984d822023-11-24T01:51:37ZengMDPI AGJournal of Clinical Medicine2077-03832022-03-01116172310.3390/jcm11061723Prevention of Peripheral Distal Polyneuropathy in Patients with Diabetes: A Systematic ReviewLidia Carvajal-Moreno0Manuel Coheña-Jiménez1Irene García-Ventura2Manuel Pabón-Carrasco3Ana Juana Pérez-Belloso4Department of Podiatry, University of Seville, 41009 Seville, SpainDepartment of Podiatry, University of Seville, 41009 Seville, SpainDepartment of Podiatry, University of Seville, 41009 Seville, SpainSpanish Red Cross Nursing School, University of Seville, Avda. de la Cruz Roja, nº 1 Dpdo., 41009 Seville, SpainDepartment of Podiatry, University of Seville, 41009 Seville, SpainBackground: Diabetic peripheral neuropathy (DPN) is the most frequent chronic complication and is that which generates the highest disability and mortality in diabetes mellitus (DM). As it is currently the only microvascular complication of DM without a specific treatment, prevention is essential. The aim of this study was to determine the most effective preventive strategy to avoid or delay the appearance and/or development of DPN in patients with DM. Methods: A systematic search was carried out in the main health science databases (PubMed, Scopus, CINAHL, PEDro and The Cochrane Library) from 1 January 2010 to 31 August 2020. The study selection was conducted by two independent reviewers and data extraction was performed by the author. The eligibility criteria included randomized clinical trials (RCTs) and cohort studies from RCTs. Results: Eleven studies were selected that included 23,595 participants with DM. The interventions evaluated were intensive or standard glycemic control, the use of drugs to achieve glycemic control, and the promotion of a healthy lifestyle and exercise. Intensive glucose control achieved a significant reduction in the development of DPN in TIDM patients, and lifestyle modifications and exercise achieved it moderately in TIIDM patients. Conclusions: The main preventive strategy for DPN is intensive glycemic control with a target HbA1c < 6% in patients with TIDM and standard control of 7.0–7.9 in patients with TIIDM, incorporating lifestyle modifications.https://www.mdpi.com/2077-0383/11/6/1723diabetes mellitusdiabetic complicationsdiabetic neuropathyprevention and controlevidencesystematic review |
spellingShingle | Lidia Carvajal-Moreno Manuel Coheña-Jiménez Irene García-Ventura Manuel Pabón-Carrasco Ana Juana Pérez-Belloso Prevention of Peripheral Distal Polyneuropathy in Patients with Diabetes: A Systematic Review Journal of Clinical Medicine diabetes mellitus diabetic complications diabetic neuropathy prevention and control evidence systematic review |
title | Prevention of Peripheral Distal Polyneuropathy in Patients with Diabetes: A Systematic Review |
title_full | Prevention of Peripheral Distal Polyneuropathy in Patients with Diabetes: A Systematic Review |
title_fullStr | Prevention of Peripheral Distal Polyneuropathy in Patients with Diabetes: A Systematic Review |
title_full_unstemmed | Prevention of Peripheral Distal Polyneuropathy in Patients with Diabetes: A Systematic Review |
title_short | Prevention of Peripheral Distal Polyneuropathy in Patients with Diabetes: A Systematic Review |
title_sort | prevention of peripheral distal polyneuropathy in patients with diabetes a systematic review |
topic | diabetes mellitus diabetic complications diabetic neuropathy prevention and control evidence systematic review |
url | https://www.mdpi.com/2077-0383/11/6/1723 |
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