Immunological abnormalities of acquired immunodeficiency syndrome and related disorders in patients from Rio de Janeiro, Brazil

Immunological abnormalities of acquired immunodeficiency syndrome and related disorders in patients from Rio de Janeiro, Brazil

The immunoloical profile of acquired immunodeficiency syndrome (AIDS) and chronic lymphadenopathy syndrome (CLAS) in 15 and 11 Brazilian patients, respectively, was studied. The AIDS patients showed reduced percentage of total T (CD3) and T-helper-inducer (CD4) lymphocytes, relative increase in numb...

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Bibliographic Details
Main Authors: W. Miranda-Silva, B. Galvão-Castro, M. G. Bonecini-Almeida, C. T. Daniel-Ribeiro, F. S. Sion, C. A. Moraes de Sá
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 1988-09-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
AIDS
alterações da resposta imune humoral e celular
lymphocyte and humoral alterations
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761988000300007
Description
Summary:The immunoloical profile of acquired immunodeficiency syndrome (AIDS) and chronic lymphadenopathy syndrome (CLAS) in 15 and 11 Brazilian patients, respectively, was studied. The AIDS patients showed reduced percentage of total T (CD3) and T-helper-inducer (CD4) lymphocytes, relative increase in numbers of T-suppressor-cytotoxic (CD8) cells and a marked inversion of T-helper-inducer/suppressor-cytotoxic (CD4/CD8) ratio. Lymphoproliferative responses to PHA, ConA, PPD and PWM were diminished. Hypergamaglobulinemia and high levels of circulating immune complexes were also found. The CLAS patients also showed important immunological alterations, but not so intense as those with AIDS. These data seems to be similar to those observed in other parts of the world.<br>Alterações imunológicas na Síndrome de Imunodeficiência Adquirida em pacientes do Rio de Janeiro, Brasil. O perfil imunológico de 15 pacientes com Síndrome de Imunodeficiência Adquirida (AIDS) e 11 com Síndrome de Linfadenipatia Crônica, foram estudados. Os pacientes com AIDS mostraram reduzida percentagem de linfócitos T (CD3) totais e T auxiliares (CD4), aumento relativo no número de linfócito T-supressores (CD8) e uma marcante inversão na relação T-auxiliares/supressores (CD4/CD8). A resposta linfoproliferativa para PHA, ConA, PPD e PWN, estava diminuída. Foi também observado hipergamaglobulinemia e níveis aumentados de complexos imunes circulantes. Os pacientes com Síndrome de Linfadenopatia Crônica também mostraram importantes alterações imunológicas, mas não tão intensas como nos de AIDS. Estes dados são similares aos observados nos Estados Unidos e na Europa.
ISSN:0074-0276
1678-8060

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