The pandemic toll and post-acute sequelae of SARS-CoV-2 in healthcare workers at a Swiss University Hospital
Healthcare workers have potentially been among the most exposed to SARS-CoV-2 infection as well as the deleterious toll of the pandemic. This study has the objective to differentiate the pandemic toll from post-acute sequelae of SARS-CoV-2 infection in healthcare workers compared to the general popu...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-10-01
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| Series: | Preventive Medicine Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211335522002066 |
| _version_ | 1811267099116437504 |
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| author | Mayssam Nehme Laure Vieux Delphine S. Courvoisier Olivia Braillard Hervé Spechbach Frederique Jacquerioz Julien Salamun Frederic Assal Frederic Lador Matteo Coen Thomas Agoritsas Jean-Luc Reny Christophe Graf Lamyae Benzakour Riccardo Favale Paola M. Soccal Guido Bondolfi Aglaé Tardin Dina Zekry Silvia Stringhini Stéphanie Baggio Stéphane Genevay Kim Lauper Philippe Meyer Nana Kwabena Poku Basile N. Landis Marwène Grira José Sandoval Julien Ehrsam Simon Regard Camille Genecand Garance Kopp Ivan Guerreiro Gilles Allali Pauline Vetter Laurent Kaiser François Chappuis Catherine Chenaud Idris Guessous |
| author_facet | Mayssam Nehme Laure Vieux Delphine S. Courvoisier Olivia Braillard Hervé Spechbach Frederique Jacquerioz Julien Salamun Frederic Assal Frederic Lador Matteo Coen Thomas Agoritsas Jean-Luc Reny Christophe Graf Lamyae Benzakour Riccardo Favale Paola M. Soccal Guido Bondolfi Aglaé Tardin Dina Zekry Silvia Stringhini Stéphanie Baggio Stéphane Genevay Kim Lauper Philippe Meyer Nana Kwabena Poku Basile N. Landis Marwène Grira José Sandoval Julien Ehrsam Simon Regard Camille Genecand Garance Kopp Ivan Guerreiro Gilles Allali Pauline Vetter Laurent Kaiser François Chappuis Catherine Chenaud Idris Guessous |
| author_sort | Mayssam Nehme |
| collection | DOAJ |
| description | Healthcare workers have potentially been among the most exposed to SARS-CoV-2 infection as well as the deleterious toll of the pandemic. This study has the objective to differentiate the pandemic toll from post-acute sequelae of SARS-CoV-2 infection in healthcare workers compared to the general population.The study was conducted between April and July 2021 at the Geneva University Hospitals, Switzerland. Eligible participants were all tested staff, and outpatient individuals tested for SARS-CoV-2 at the same hospital. The primary outcome was the prevalence of symptoms in healthcare workers compared to the general population, with measures of COVID-related symptoms and functional impairment, using prevalence estimates and multivariable logistic regression models.Healthcare workers (n = 3083) suffered mostly from fatigue (25.5 %), headache (10.0 %), difficulty concentrating (7.9 %), exhaustion/burnout (7.1 %), insomnia (6.2 %), myalgia (6.7 %) and arthralgia (6.3 %). Regardless of SARS-CoV-2 infection, all symptoms were significantly higher in healthcare workers than the general population (n = 3556). SARS-CoV-2 infection in healthcare workers was associated with loss or change in smell, loss or change in taste, palpitations, dyspnea, difficulty concentrating, fatigue, and headache. Functional impairment was more significant in healthcare workers compared to the general population (aOR 2.28; 1.76–2.96), with a positive association with SARS-CoV-2 infection (aOR 3.81; 2.59–5.60).Symptoms and functional impairment in healthcare workers were increased compared to the general population, and potentially related to the pandemic toll as well as post-acute sequelae of SARS-CoV-2 infection. These findings are of concern, considering the essential role of healthcare workers in caring for all patients including and beyond COVID-19. |
| first_indexed | 2024-04-12T20:55:00Z |
| format | Article |
| id | doaj.art-b475074a7aa04b73b53cc8999f3d1a1a |
| institution | Directory Open Access Journal |
| issn | 2211-3355 |
| language | English |
| last_indexed | 2024-04-12T20:55:00Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Preventive Medicine Reports |
| spelling | doaj.art-b475074a7aa04b73b53cc8999f3d1a1a2022-12-22T03:17:01ZengElsevierPreventive Medicine Reports2211-33552022-10-0129101899The pandemic toll and post-acute sequelae of SARS-CoV-2 in healthcare workers at a Swiss University HospitalMayssam Nehme0Laure Vieux1Delphine S. Courvoisier2Olivia Braillard3Hervé Spechbach4Frederique Jacquerioz5Julien Salamun6Frederic Assal7Frederic Lador8Matteo Coen9Thomas Agoritsas10Jean-Luc Reny11Christophe Graf12Lamyae Benzakour13Riccardo Favale14Paola M. Soccal15Guido Bondolfi16Aglaé Tardin17Dina Zekry18Silvia Stringhini19Stéphanie Baggio20Stéphane Genevay21Kim Lauper22Philippe Meyer23Nana Kwabena Poku24Basile N. Landis25Marwène Grira26José Sandoval27Julien Ehrsam28Simon Regard29Camille Genecand30Garance Kopp31Ivan Guerreiro32Gilles Allali33Pauline Vetter34Laurent Kaiser35François Chappuis36Catherine Chenaud37Idris Guessous38Division of Primary care Medicine of the Geneva University Hospitals, Geneva, Switzerland; Corresponding author.Division of Occupational Medicine, Geneva University Hospital, Geneva, SwitzerlandQuality of Care Division, Medical Directorate, Geneva University Hospitals, Geneva, Switzerland; Cantonal Health Service, General Directorate for Health, Geneva, SwitzerlandDivision of Primary care Medicine of the Geneva University Hospitals, Geneva, SwitzerlandDivision of Primary care Medicine of the Geneva University Hospitals, Geneva, SwitzerlandDivision of Primary care Medicine of the Geneva University Hospitals, Geneva, Switzerland; Division of Tropical and Humanitarian Medicine, Geneva University Hospitals, Geneva, Switzerland; Geneva Center for Emerging Viral Diseases, Geneva University Hospitals, Geneva, SwitzerlandDivision of Primary care Medicine of the Geneva University Hospitals, Geneva, SwitzerlandFaculty of Medicine, University of Geneva, Geneva, Switzerland; Division of Neurology, Geneva University Hospitals, Geneva, SwitzerlandDivision of Pulmonary Medicine, Geneva University Hospitals, Geneva, SwitzerlandDivision of General Internal Medicine, Geneva University Hospitals, Geneva, SwitzerlandDivision of General Internal Medicine, Geneva University Hospitals, Geneva, SwitzerlandDivision of General Internal Medicine, Geneva University Hospitals, Geneva, SwitzerlandDepartment of Rehabilitation and Geriatrics, Geneva University Hospitals, Geneva, SwitzerlandDivision of Psychiatry, Geneva University Hospitals, Geneva, SwitzerlandDivision of Psychiatry, Geneva University Hospitals, Geneva, SwitzerlandDivision of Pulmonary Medicine, Geneva University Hospitals, Geneva, SwitzerlandDivision of Psychiatry, Geneva University Hospitals, Geneva, SwitzerlandCantonal Health Service, General Directorate for Health, Geneva, SwitzerlandDepartment of Rehabilitation and Geriatrics, Geneva University Hospitals, Geneva, SwitzerlandDivision of Primary care Medicine of the Geneva University Hospitals, Geneva, Switzerland; Faculty of Medicine, University of Geneva, Geneva, SwitzerlandInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland; Division of Prison Health, Geneva University Hospitals, Geneva, SwitzerlandDivision of Rheumatology, Geneva University Hospitals, Geneva, SwitzerlandDivision of Rheumatology, Geneva University Hospitals, Geneva, SwitzerlandDivision of Cardiology, Geneva University Hospitals, Geneva, SwitzerlandDivision of Cardiology, Geneva University Hospitals, Geneva, SwitzerlandDivision of Otolaryngology, Geneva University Hospitals, Geneva, SwitzerlandDivision of Primary care Medicine of the Geneva University Hospitals, Geneva, SwitzerlandDepartment of Oncology, Geneva University Hospitals, Geneva, SwitzerlandDivision of Primary care Medicine of the Geneva University Hospitals, Geneva, Switzerland; Department of Medical Information Sciences, Geneva University Hospitals, Geneva, SwitzerlandCantonal Health Service, General Directorate for Health, Geneva, Switzerland; Division of Emergency Medicine, Geneva University Hospitals, Geneva, SwitzerlandCantonal Health Service, General Directorate for Health, Geneva, SwitzerlandDivision of Pulmonary Medicine, Geneva University Hospitals, Geneva, SwitzerlandDivision of Pulmonary Medicine, Geneva University Hospitals, Geneva, SwitzerlandDivision of Neurology, Geneva University Hospitals, Geneva, Switzerland; Leenaards Memory Center, Lausanne University Hospital, Lausanne, SwitzerlandDivision of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland; Geneva Center for Emerging Viral Diseases, Geneva University Hospitals, Geneva, Switzerland; Division of Laboratory Medicine, Laboratory of Virology, Geneva University Hospitals, Geneva, SwitzerlandDivision of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland; Geneva Center for Emerging Viral Diseases, Geneva University Hospitals, Geneva, Switzerland; Division of Laboratory Medicine, Laboratory of Virology, Geneva University Hospitals, Geneva, SwitzerlandDivision of Tropical and Humanitarian Medicine, Geneva University Hospitals, Geneva, Switzerland; Faculty of Medicine, University of Geneva, Geneva, SwitzerlandDivision of Occupational Medicine, Geneva University Hospital, Geneva, SwitzerlandDivision of Primary care Medicine of the Geneva University Hospitals, Geneva, Switzerland; Faculty of Medicine, University of Geneva, Geneva, SwitzerlandHealthcare workers have potentially been among the most exposed to SARS-CoV-2 infection as well as the deleterious toll of the pandemic. This study has the objective to differentiate the pandemic toll from post-acute sequelae of SARS-CoV-2 infection in healthcare workers compared to the general population.The study was conducted between April and July 2021 at the Geneva University Hospitals, Switzerland. Eligible participants were all tested staff, and outpatient individuals tested for SARS-CoV-2 at the same hospital. The primary outcome was the prevalence of symptoms in healthcare workers compared to the general population, with measures of COVID-related symptoms and functional impairment, using prevalence estimates and multivariable logistic regression models.Healthcare workers (n = 3083) suffered mostly from fatigue (25.5 %), headache (10.0 %), difficulty concentrating (7.9 %), exhaustion/burnout (7.1 %), insomnia (6.2 %), myalgia (6.7 %) and arthralgia (6.3 %). Regardless of SARS-CoV-2 infection, all symptoms were significantly higher in healthcare workers than the general population (n = 3556). SARS-CoV-2 infection in healthcare workers was associated with loss or change in smell, loss or change in taste, palpitations, dyspnea, difficulty concentrating, fatigue, and headache. Functional impairment was more significant in healthcare workers compared to the general population (aOR 2.28; 1.76–2.96), with a positive association with SARS-CoV-2 infection (aOR 3.81; 2.59–5.60).Symptoms and functional impairment in healthcare workers were increased compared to the general population, and potentially related to the pandemic toll as well as post-acute sequelae of SARS-CoV-2 infection. These findings are of concern, considering the essential role of healthcare workers in caring for all patients including and beyond COVID-19.http://www.sciencedirect.com/science/article/pii/S2211335522002066 |
| spellingShingle | Mayssam Nehme Laure Vieux Delphine S. Courvoisier Olivia Braillard Hervé Spechbach Frederique Jacquerioz Julien Salamun Frederic Assal Frederic Lador Matteo Coen Thomas Agoritsas Jean-Luc Reny Christophe Graf Lamyae Benzakour Riccardo Favale Paola M. Soccal Guido Bondolfi Aglaé Tardin Dina Zekry Silvia Stringhini Stéphanie Baggio Stéphane Genevay Kim Lauper Philippe Meyer Nana Kwabena Poku Basile N. Landis Marwène Grira José Sandoval Julien Ehrsam Simon Regard Camille Genecand Garance Kopp Ivan Guerreiro Gilles Allali Pauline Vetter Laurent Kaiser François Chappuis Catherine Chenaud Idris Guessous The pandemic toll and post-acute sequelae of SARS-CoV-2 in healthcare workers at a Swiss University Hospital Preventive Medicine Reports |
| title | The pandemic toll and post-acute sequelae of SARS-CoV-2 in healthcare workers at a Swiss University Hospital |
| title_full | The pandemic toll and post-acute sequelae of SARS-CoV-2 in healthcare workers at a Swiss University Hospital |
| title_fullStr | The pandemic toll and post-acute sequelae of SARS-CoV-2 in healthcare workers at a Swiss University Hospital |
| title_full_unstemmed | The pandemic toll and post-acute sequelae of SARS-CoV-2 in healthcare workers at a Swiss University Hospital |
| title_short | The pandemic toll and post-acute sequelae of SARS-CoV-2 in healthcare workers at a Swiss University Hospital |
| title_sort | pandemic toll and post acute sequelae of sars cov 2 in healthcare workers at a swiss university hospital |
| url | http://www.sciencedirect.com/science/article/pii/S2211335522002066 |
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