Targeting Tryptophan Catabolism in Cancer Immunotherapy Era: Challenges and Perspectives

Targeting Tryptophan Catabolism in Cancer Immunotherapy Era: Challenges and Perspectives

Metabolism of tryptophan (Trp), an essential amino acid, represent a major metabolic pathway that both promotes tumor cell intrinsic malignant properties as well as restricts antitumour immunity, thus emerging as a drug development target for cancer immunotherapy. Three cytosolic enzymes, namely ind...

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Bibliographic Details
Main Authors: Florent Peyraud, Jean-Philippe Guegan, Dominique Bodet, Sophie Cousin, Alban Bessede, Antoine Italiano
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
indoleamine 2,3-dioxygenase
cancer
tryptophan metabolism
kynurenine
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.807271/full

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