Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus
Components of the translation apparatus, including ribosomal proteins, have been found in cell nuclei in various organisms. Components of the translation apparatus are involved in various nuclear processes, particularly those associated with genome integrity control and the nuclear stages of gene ex...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/11/3239 |
| _version_ | 1797510815392202752 |
|---|---|
| author | Zaur M. Kachaev Sergey D. Ivashchenko Eugene N. Kozlov Lyubov A. Lebedeva Yulii V. Shidlovskii |
| author_facet | Zaur M. Kachaev Sergey D. Ivashchenko Eugene N. Kozlov Lyubov A. Lebedeva Yulii V. Shidlovskii |
| author_sort | Zaur M. Kachaev |
| collection | DOAJ |
| description | Components of the translation apparatus, including ribosomal proteins, have been found in cell nuclei in various organisms. Components of the translation apparatus are involved in various nuclear processes, particularly those associated with genome integrity control and the nuclear stages of gene expression, such as transcription, mRNA processing, and mRNA export. Components of the translation apparatus control intranuclear trafficking; the nuclear import and export of RNA and proteins; and regulate the activity, stability, and functional recruitment of nuclear proteins. The nuclear translocation of these components is often involved in the cell response to stimulation and stress, in addition to playing critical roles in oncogenesis and viral infection. Many components of the translation apparatus are moonlighting proteins, involved in integral cell stress response and coupling of gene expression subprocesses. Thus, this phenomenon represents a significant interest for both basic and applied molecular biology. Here, we provide an overview of the current data regarding the molecular functions of translation factors and ribosomal proteins in the cell nucleus. |
| first_indexed | 2024-03-10T05:36:37Z |
| format | Article |
| id | doaj.art-b4767ed2378747278648884b1458ecba |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T05:36:37Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-b4767ed2378747278648884b1458ecba2023-11-22T22:53:20ZengMDPI AGCells2073-44092021-11-011011323910.3390/cells10113239Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell NucleusZaur M. Kachaev0Sergey D. Ivashchenko1Eugene N. Kozlov2Lyubov A. Lebedeva3Yulii V. Shidlovskii4Department of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, RussiaDepartment of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, RussiaDepartment of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, RussiaDepartment of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, RussiaDepartment of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, RussiaComponents of the translation apparatus, including ribosomal proteins, have been found in cell nuclei in various organisms. Components of the translation apparatus are involved in various nuclear processes, particularly those associated with genome integrity control and the nuclear stages of gene expression, such as transcription, mRNA processing, and mRNA export. Components of the translation apparatus control intranuclear trafficking; the nuclear import and export of RNA and proteins; and regulate the activity, stability, and functional recruitment of nuclear proteins. The nuclear translocation of these components is often involved in the cell response to stimulation and stress, in addition to playing critical roles in oncogenesis and viral infection. Many components of the translation apparatus are moonlighting proteins, involved in integral cell stress response and coupling of gene expression subprocesses. Thus, this phenomenon represents a significant interest for both basic and applied molecular biology. Here, we provide an overview of the current data regarding the molecular functions of translation factors and ribosomal proteins in the cell nucleus.https://www.mdpi.com/2073-4409/10/11/3239translation factorribosomal proteingene expressionnucleusstresscell response |
| spellingShingle | Zaur M. Kachaev Sergey D. Ivashchenko Eugene N. Kozlov Lyubov A. Lebedeva Yulii V. Shidlovskii Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus Cells translation factor ribosomal protein gene expression nucleus stress cell response |
| title | Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus |
| title_full | Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus |
| title_fullStr | Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus |
| title_full_unstemmed | Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus |
| title_short | Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus |
| title_sort | localization and functional roles of components of the translation apparatus in the eukaryotic cell nucleus |
| topic | translation factor ribosomal protein gene expression nucleus stress cell response |
| url | https://www.mdpi.com/2073-4409/10/11/3239 |
| work_keys_str_mv | AT zaurmkachaev localizationandfunctionalrolesofcomponentsofthetranslationapparatusintheeukaryoticcellnucleus AT sergeydivashchenko localizationandfunctionalrolesofcomponentsofthetranslationapparatusintheeukaryoticcellnucleus AT eugenenkozlov localizationandfunctionalrolesofcomponentsofthetranslationapparatusintheeukaryoticcellnucleus AT lyubovalebedeva localizationandfunctionalrolesofcomponentsofthetranslationapparatusintheeukaryoticcellnucleus AT yuliivshidlovskii localizationandfunctionalrolesofcomponentsofthetranslationapparatusintheeukaryoticcellnucleus |