Real-Time Phase-Contrast MRI to Monitor Cervical Blood and Cerebrospinal Fluid Flow Beat-by-Beat Variability
Beat-by-beat variability (BBV) rhythms are observed in both cardiovascular (CV) and intracranial (IC) compartments, yet interactions between the two are not fully understood. Real-Time Phase-Contrast (RT-PC) MRI sequence was acquired for 30 healthy volunteers at 1st cervical level on a 3T scanner. T...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/12/6/417 |
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| author | Giuseppe Baselli Federica Fasani Laura Pelizzari Marta Cazzoli Francesca Baglio Maria Marcella Laganà |
| author_facet | Giuseppe Baselli Federica Fasani Laura Pelizzari Marta Cazzoli Francesca Baglio Maria Marcella Laganà |
| author_sort | Giuseppe Baselli |
| collection | DOAJ |
| description | Beat-by-beat variability (BBV) rhythms are observed in both cardiovascular (CV) and intracranial (IC) compartments, yet interactions between the two are not fully understood. Real-Time Phase-Contrast (RT-PC) MRI sequence was acquired for 30 healthy volunteers at 1st cervical level on a 3T scanner. The arterial (AF), venous (VF), and cerebrospinal fluid (CSF) flow (CSFF) were computed as velocity integrals over the internal carotid artery, internal jugular vein, and CSF. AF, VF, and CSFF signals were segmented in inspiration and expiration beats, to assess the respiration influence. Systolic and diastolic BBV, and heart period series underwent autoregressive power spectral density analysis, to evaluate the low-frequency (LF, Mayer waves) and high frequency (HF, respiratory waves) components. The diastolic VF had the largest BBV. LF power was high in the diastolic AF series, poor in all CSFF series. The pulse wave analyses revealed higher mean amplitude during inspiration. Findings suggests a possible role of LF modulation of IC resistances and propagation of HF waves from VF to AF and CCSF. PC-RT-MRI could provide new insight into the interaction between CV and IC regulation and pave the way for a detailed analysis of the cerebrovascular effects of varied respiration patterns due to exercise and rehabilitation. |
| first_indexed | 2024-03-10T00:17:14Z |
| format | Article |
| id | doaj.art-b477bac0772a4b0eb6ae713ae6d319c3 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-10T00:17:14Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-b477bac0772a4b0eb6ae713ae6d319c32023-11-23T15:49:15ZengMDPI AGBiosensors2079-63742022-06-0112641710.3390/bios12060417Real-Time Phase-Contrast MRI to Monitor Cervical Blood and Cerebrospinal Fluid Flow Beat-by-Beat VariabilityGiuseppe Baselli0Federica Fasani1Laura Pelizzari2Marta Cazzoli3Francesca Baglio4Maria Marcella Laganà5Department of Electronics, Information, and Bioengineering, Politecnico di Milano, 20133 Milan, ItalyDepartment of Electronics, Information, and Bioengineering, Politecnico di Milano, 20133 Milan, ItalyIRCCS Fondazione Don Carlo Gnocchi ONLUS, 20148 Milan, ItalyIRCCS Fondazione Don Carlo Gnocchi ONLUS, 20148 Milan, ItalyIRCCS Fondazione Don Carlo Gnocchi ONLUS, 20148 Milan, ItalyIRCCS Fondazione Don Carlo Gnocchi ONLUS, 20148 Milan, ItalyBeat-by-beat variability (BBV) rhythms are observed in both cardiovascular (CV) and intracranial (IC) compartments, yet interactions between the two are not fully understood. Real-Time Phase-Contrast (RT-PC) MRI sequence was acquired for 30 healthy volunteers at 1st cervical level on a 3T scanner. The arterial (AF), venous (VF), and cerebrospinal fluid (CSF) flow (CSFF) were computed as velocity integrals over the internal carotid artery, internal jugular vein, and CSF. AF, VF, and CSFF signals were segmented in inspiration and expiration beats, to assess the respiration influence. Systolic and diastolic BBV, and heart period series underwent autoregressive power spectral density analysis, to evaluate the low-frequency (LF, Mayer waves) and high frequency (HF, respiratory waves) components. The diastolic VF had the largest BBV. LF power was high in the diastolic AF series, poor in all CSFF series. The pulse wave analyses revealed higher mean amplitude during inspiration. Findings suggests a possible role of LF modulation of IC resistances and propagation of HF waves from VF to AF and CCSF. PC-RT-MRI could provide new insight into the interaction between CV and IC regulation and pave the way for a detailed analysis of the cerebrovascular effects of varied respiration patterns due to exercise and rehabilitation.https://www.mdpi.com/2079-6374/12/6/417arterovenous flowcerebrospinal fluid flowMRIbeat-by-beat variabilityrehabilitationneurodegeneration |
| spellingShingle | Giuseppe Baselli Federica Fasani Laura Pelizzari Marta Cazzoli Francesca Baglio Maria Marcella Laganà Real-Time Phase-Contrast MRI to Monitor Cervical Blood and Cerebrospinal Fluid Flow Beat-by-Beat Variability Biosensors arterovenous flow cerebrospinal fluid flow MRI beat-by-beat variability rehabilitation neurodegeneration |
| title | Real-Time Phase-Contrast MRI to Monitor Cervical Blood and Cerebrospinal Fluid Flow Beat-by-Beat Variability |
| title_full | Real-Time Phase-Contrast MRI to Monitor Cervical Blood and Cerebrospinal Fluid Flow Beat-by-Beat Variability |
| title_fullStr | Real-Time Phase-Contrast MRI to Monitor Cervical Blood and Cerebrospinal Fluid Flow Beat-by-Beat Variability |
| title_full_unstemmed | Real-Time Phase-Contrast MRI to Monitor Cervical Blood and Cerebrospinal Fluid Flow Beat-by-Beat Variability |
| title_short | Real-Time Phase-Contrast MRI to Monitor Cervical Blood and Cerebrospinal Fluid Flow Beat-by-Beat Variability |
| title_sort | real time phase contrast mri to monitor cervical blood and cerebrospinal fluid flow beat by beat variability |
| topic | arterovenous flow cerebrospinal fluid flow MRI beat-by-beat variability rehabilitation neurodegeneration |
| url | https://www.mdpi.com/2079-6374/12/6/417 |
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