Up-regulation of LCN2 in the anterior cingulate cortex contributes to neural injury-induced chronic pain

Up-regulation of LCN2 in the anterior cingulate cortex contributes to neural injury-induced chronic pain

Chronic pain caused by disease or injury affects more than 30% of the general population. The molecular and cellular mechanisms underpinning the development of chronic pain remain unclear, resulting in scant effective treatments. Here, we combined electrophysiological recording, in vivo two-photon (...

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Bibliographic Details
Main Authors: Xiang-Jie Song, Chen-Ling Yang, Danyang Chen, Yumeng Yang, Yu Mao, Peng Cao, Aijun Jiang, Wei Wang, Zhi Zhang, Wenjuan Tao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
chronic pain
ACC
LCN2
chemogenetics
neuronal hyperactivity
in vivo 2P calcium imaging
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1140769/full

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