Chernobyl’s Aftermath: Multiple Manifestations of Basalioma in a Patient after Radioactive Contamination in 1986
Background: The Chernobyl nuclear disaster is still considered the worst nuclear accident in history. The particles were dispersed over the former USSR and large parts of Western Europe, leading to radioactive exposure to more than 10 million people. Radioactivity is a risk factor for the developmen...
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| Format: | Article |
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MDPI AG
2023-10-01
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| Series: | Radiation |
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| Online Access: | https://www.mdpi.com/2673-592X/3/4/16 |
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| author | Marcel Ebeling Konrad Steinestel Michael Grunert Alexander Schramm Frank Wilde Sebastian Pietzka Andreas Sakkas |
| author_facet | Marcel Ebeling Konrad Steinestel Michael Grunert Alexander Schramm Frank Wilde Sebastian Pietzka Andreas Sakkas |
| author_sort | Marcel Ebeling |
| collection | DOAJ |
| description | Background: The Chernobyl nuclear disaster is still considered the worst nuclear accident in history. The particles were dispersed over the former USSR and large parts of Western Europe, leading to radioactive exposure to more than 10 million people. Radioactivity is a risk factor for the development of basal cell carcinoma (BCC), since radiation-induced mutations in both Sonic hedgehog (Shh) signaling pathway genes and <i>TP53</i> have been described. Methods: We present the case of a patient with a history of radiation exposure following the 1986 Chernobyl accident who presented to our outpatient clinic with recurrent basal cell carcinoma in the facial region. Case: The patient presented to our clinic with two facial lesions suspicious for BCC. Although there were no typical risk factors, 11 BCCs had previously been removed. The patient had been building shelters for the construction workers working on the sarcophagus around the destroyed reactor immediately after the 1986 accident. Staging using an 18F-FDG-PET/CT as well as ultrasound of the abdomen revealed no other tumor manifestations. Diagnostic excision of the two facial lesions was performed, and a histopathological workup revealed BCC at the right temporal region and acanthopapillomatosis with no sign of malignancy at the corner of the mouth. After presentation to the tumor board, complete resection of the BCC was initiated. Conclusions: This case demonstrates the value of early use of 18F-FDG-PET/CT in staging/restaging to visualize BCC location, local spread and potential metastases or secondary tumors and to aid in the decision for therapeutic management. |
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| language | English |
| last_indexed | 2024-03-08T20:25:21Z |
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| series | Radiation |
| spelling | doaj.art-b47aaf39fe5a47cd98cb79d54c5276862023-12-22T14:38:13ZengMDPI AGRadiation2673-592X2023-10-013420321010.3390/radiation3040016Chernobyl’s Aftermath: Multiple Manifestations of Basalioma in a Patient after Radioactive Contamination in 1986Marcel Ebeling0Konrad Steinestel1Michael Grunert2Alexander Schramm3Frank Wilde4Sebastian Pietzka5Andreas Sakkas6Department of Oral and Plastic Maxillofacial Surgery, German Armed Forces Hospital Ulm, Academic Hospital of the University of Ulm, Oberer Eselsberg 40, 89081 Ulm, GermanyInstitute of Pathology and Molecular Pathology, German Armed Forces Hospital Ulm, Academic Hospital of the University of Ulm, Oberer Eselsberg 40, 89081 Ulm, GermanyDepartment of Nuclear Medicine, German Armed Forces Hospital Ulm, Academic Hospital of the University of Ulm, Oberer Eselsberg 40, 89081 Ulm, GermanyDepartment of Oral and Plastic Maxillofacial Surgery, German Armed Forces Hospital Ulm, Academic Hospital of the University of Ulm, Oberer Eselsberg 40, 89081 Ulm, GermanyDepartment of Oral and Plastic Maxillofacial Surgery, German Armed Forces Hospital Ulm, Academic Hospital of the University of Ulm, Oberer Eselsberg 40, 89081 Ulm, GermanyDepartment of Oral and Plastic Maxillofacial Surgery, German Armed Forces Hospital Ulm, Academic Hospital of the University of Ulm, Oberer Eselsberg 40, 89081 Ulm, GermanyDepartment of Oral and Plastic Maxillofacial Surgery, German Armed Forces Hospital Ulm, Academic Hospital of the University of Ulm, Oberer Eselsberg 40, 89081 Ulm, GermanyBackground: The Chernobyl nuclear disaster is still considered the worst nuclear accident in history. The particles were dispersed over the former USSR and large parts of Western Europe, leading to radioactive exposure to more than 10 million people. Radioactivity is a risk factor for the development of basal cell carcinoma (BCC), since radiation-induced mutations in both Sonic hedgehog (Shh) signaling pathway genes and <i>TP53</i> have been described. Methods: We present the case of a patient with a history of radiation exposure following the 1986 Chernobyl accident who presented to our outpatient clinic with recurrent basal cell carcinoma in the facial region. Case: The patient presented to our clinic with two facial lesions suspicious for BCC. Although there were no typical risk factors, 11 BCCs had previously been removed. The patient had been building shelters for the construction workers working on the sarcophagus around the destroyed reactor immediately after the 1986 accident. Staging using an 18F-FDG-PET/CT as well as ultrasound of the abdomen revealed no other tumor manifestations. Diagnostic excision of the two facial lesions was performed, and a histopathological workup revealed BCC at the right temporal region and acanthopapillomatosis with no sign of malignancy at the corner of the mouth. After presentation to the tumor board, complete resection of the BCC was initiated. Conclusions: This case demonstrates the value of early use of 18F-FDG-PET/CT in staging/restaging to visualize BCC location, local spread and potential metastases or secondary tumors and to aid in the decision for therapeutic management.https://www.mdpi.com/2673-592X/3/4/16basaliomaradiationnuclear disasterPET-CT |
| spellingShingle | Marcel Ebeling Konrad Steinestel Michael Grunert Alexander Schramm Frank Wilde Sebastian Pietzka Andreas Sakkas Chernobyl’s Aftermath: Multiple Manifestations of Basalioma in a Patient after Radioactive Contamination in 1986 Radiation basalioma radiation nuclear disaster PET-CT |
| title | Chernobyl’s Aftermath: Multiple Manifestations of Basalioma in a Patient after Radioactive Contamination in 1986 |
| title_full | Chernobyl’s Aftermath: Multiple Manifestations of Basalioma in a Patient after Radioactive Contamination in 1986 |
| title_fullStr | Chernobyl’s Aftermath: Multiple Manifestations of Basalioma in a Patient after Radioactive Contamination in 1986 |
| title_full_unstemmed | Chernobyl’s Aftermath: Multiple Manifestations of Basalioma in a Patient after Radioactive Contamination in 1986 |
| title_short | Chernobyl’s Aftermath: Multiple Manifestations of Basalioma in a Patient after Radioactive Contamination in 1986 |
| title_sort | chernobyl s aftermath multiple manifestations of basalioma in a patient after radioactive contamination in 1986 |
| topic | basalioma radiation nuclear disaster PET-CT |
| url | https://www.mdpi.com/2673-592X/3/4/16 |
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