Rapamycin incorporating hydrogel improves the progression of osteoarthritis by inducing synovial macrophages polarization and reducing intra-articular inflammation

Rapamycin incorporating hydrogel improves the progression of osteoarthritis by inducing synovial macrophages polarization and reducing intra-articular inflammation

In the macrophage-specific mTORC1 signaling activation model, the synovial macrophages polarized toward M1, thus aggravating synovitis and progression of OA. Therefore, intra-articular injection of rapamycin, a classical mTORC1 inhibitor, may show great potential for alleviating synovitis and delayi...

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Bibliographic Details
Main Authors: Bo Chen, Jibing Wang, Xing Jin, Xin Wang, Zhangling Fan, Yuxin Zhang, Xuehan Sang, Zhaoxiang Meng
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Materials & Design
Subjects:
Intra-articular injection
Hydrogel
Rapamycin
Synovial macrophages
Osteoarthritis
Online Access:http://www.sciencedirect.com/science/article/pii/S0264127522011650

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