Correlation of Significantly Decreased Serum Circulating Mesencephalic Astrocyte-Derived Neurotrophic Factor Level With an Increased Risk of Future Cardiovascular Disease in Adult Patients With Growth Hormone Deficiency
ObjectiveAdult growth hormone deficiency (AGHD) is a rare chronic inflammatory disease caused by damage to the pituitary gland and is accompanied by disorders of multiple metabolic pathways. By examining the correlation between the serum mesencephalic astrocyte-derived neurotrophic factor (MANF) lev...
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.671126/full |
| _version_ | 1818898101330509824 |
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| author | Ziyu Ren Yunting Wang Qing Chen Jiangchuan Long Rui Zhang Xun Wu Wenjie Qian Yue Chen Dongfang Liu Wei Ren |
| author_facet | Ziyu Ren Yunting Wang Qing Chen Jiangchuan Long Rui Zhang Xun Wu Wenjie Qian Yue Chen Dongfang Liu Wei Ren |
| author_sort | Ziyu Ren |
| collection | DOAJ |
| description | ObjectiveAdult growth hormone deficiency (AGHD) is a rare chronic inflammatory disease caused by damage to the pituitary gland and is accompanied by disorders of multiple metabolic pathways. By examining the correlation between the serum mesencephalic astrocyte-derived neurotrophic factor (MANF) levels of AGHD patients and those of normal controls, we hope to elucidate the close relationship among MANF, lipid metabolism and insulin resistance in AGHD and discuss the potential therapeutic value of MANF.MethodsThis study included 101 AGHD patients and 100 healthy subjects matched for sex, age, height, and weight. Anthropometric parameters and biochemical indicators such as body mass index, waist circumference, hip circumference, serum MANF level, blood lipids and insulin level were measured. The above patients were also divided into several subgroups for correlation analysis based on indicators such as insulin resistance and BMI.ResultsThe serum circulating MANF content of AGHD patients was significantly lower than that of the normal control group (5.235 (0.507-17.62) ng/ml (n=101) vs. 10.30 (1.84-16.65) ng/ml (n=100); p<0.0001), and circulating MANF levels were linearly correlated with HOMA-IR in the AGHD population (R=0.481, P=0.0041). When MANF was at pathological concentrations (lower than the mean circulating MANF of normal controls), the lowest concentration tertile (OR=21.429 p<0.0001) had a significantly higher disease odds ratio, Framingham risk score and 10-year risk of atherosclerotic cardiovascular disease than the highest concentration tertile.ConclusionsMANF has a significant correlation with insulin resistance in the AGHD state. There is a strong correlation with abnormal glucose and lipid metabolism in the obese AGHD population. MANF is also a good assessment factor for the risk of cardiovascular disease in AGHD patients and has excellent therapeutic potential. |
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| language | English |
| last_indexed | 2024-12-19T19:26:43Z |
| publishDate | 2021-06-01 |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-b47b5fdd3921481b83550cd38072152e2022-12-21T20:08:45ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-06-011210.3389/fendo.2021.671126671126Correlation of Significantly Decreased Serum Circulating Mesencephalic Astrocyte-Derived Neurotrophic Factor Level With an Increased Risk of Future Cardiovascular Disease in Adult Patients With Growth Hormone DeficiencyZiyu Ren0Yunting Wang1Qing Chen2Jiangchuan Long3Rui Zhang4Xun Wu5Wenjie Qian6Yue Chen7Dongfang Liu8Wei Ren9Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaGeneral Practice, The 958 Hospital of the People’s Liberation Army, Chongqing, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaObjectiveAdult growth hormone deficiency (AGHD) is a rare chronic inflammatory disease caused by damage to the pituitary gland and is accompanied by disorders of multiple metabolic pathways. By examining the correlation between the serum mesencephalic astrocyte-derived neurotrophic factor (MANF) levels of AGHD patients and those of normal controls, we hope to elucidate the close relationship among MANF, lipid metabolism and insulin resistance in AGHD and discuss the potential therapeutic value of MANF.MethodsThis study included 101 AGHD patients and 100 healthy subjects matched for sex, age, height, and weight. Anthropometric parameters and biochemical indicators such as body mass index, waist circumference, hip circumference, serum MANF level, blood lipids and insulin level were measured. The above patients were also divided into several subgroups for correlation analysis based on indicators such as insulin resistance and BMI.ResultsThe serum circulating MANF content of AGHD patients was significantly lower than that of the normal control group (5.235 (0.507-17.62) ng/ml (n=101) vs. 10.30 (1.84-16.65) ng/ml (n=100); p<0.0001), and circulating MANF levels were linearly correlated with HOMA-IR in the AGHD population (R=0.481, P=0.0041). When MANF was at pathological concentrations (lower than the mean circulating MANF of normal controls), the lowest concentration tertile (OR=21.429 p<0.0001) had a significantly higher disease odds ratio, Framingham risk score and 10-year risk of atherosclerotic cardiovascular disease than the highest concentration tertile.ConclusionsMANF has a significant correlation with insulin resistance in the AGHD state. There is a strong correlation with abnormal glucose and lipid metabolism in the obese AGHD population. MANF is also a good assessment factor for the risk of cardiovascular disease in AGHD patients and has excellent therapeutic potential.https://www.frontiersin.org/articles/10.3389/fendo.2021.671126/fulladult growth hormone deficiencymesencephalic astrocyte-derived neurotrophic factorinsulin resistancelipid metabolismcardiovascular risk |
| spellingShingle | Ziyu Ren Yunting Wang Qing Chen Jiangchuan Long Rui Zhang Xun Wu Wenjie Qian Yue Chen Dongfang Liu Wei Ren Correlation of Significantly Decreased Serum Circulating Mesencephalic Astrocyte-Derived Neurotrophic Factor Level With an Increased Risk of Future Cardiovascular Disease in Adult Patients With Growth Hormone Deficiency Frontiers in Endocrinology adult growth hormone deficiency mesencephalic astrocyte-derived neurotrophic factor insulin resistance lipid metabolism cardiovascular risk |
| title | Correlation of Significantly Decreased Serum Circulating Mesencephalic Astrocyte-Derived Neurotrophic Factor Level With an Increased Risk of Future Cardiovascular Disease in Adult Patients With Growth Hormone Deficiency |
| title_full | Correlation of Significantly Decreased Serum Circulating Mesencephalic Astrocyte-Derived Neurotrophic Factor Level With an Increased Risk of Future Cardiovascular Disease in Adult Patients With Growth Hormone Deficiency |
| title_fullStr | Correlation of Significantly Decreased Serum Circulating Mesencephalic Astrocyte-Derived Neurotrophic Factor Level With an Increased Risk of Future Cardiovascular Disease in Adult Patients With Growth Hormone Deficiency |
| title_full_unstemmed | Correlation of Significantly Decreased Serum Circulating Mesencephalic Astrocyte-Derived Neurotrophic Factor Level With an Increased Risk of Future Cardiovascular Disease in Adult Patients With Growth Hormone Deficiency |
| title_short | Correlation of Significantly Decreased Serum Circulating Mesencephalic Astrocyte-Derived Neurotrophic Factor Level With an Increased Risk of Future Cardiovascular Disease in Adult Patients With Growth Hormone Deficiency |
| title_sort | correlation of significantly decreased serum circulating mesencephalic astrocyte derived neurotrophic factor level with an increased risk of future cardiovascular disease in adult patients with growth hormone deficiency |
| topic | adult growth hormone deficiency mesencephalic astrocyte-derived neurotrophic factor insulin resistance lipid metabolism cardiovascular risk |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.671126/full |
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