Continuous Flow Photochemical Synthesis of 3-Methyl-4-arylmethylene Isoxazole-5(4H)-ones through Organic Photoredox Catalysis and Investigation of Their Larvicidal Activity

Continuous Flow Photochemical Synthesis of 3-Methyl-4-arylmethylene Isoxazole-5(4H)-ones through Organic Photoredox Catalysis and Investigation of Their Larvicidal Activity

Isoxazole-5(4H)-ones are heteropentacycle compounds found in several bioactive molecules with pharmaceutical and agrochemical properties. A well-known multicomponent reaction between β-ketoester, hydroxylamine, and aromatic aldehydes leads to 3-methyl-4-arylmethylene isoxazole-5(4H)-ones, in mild co...

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Bibliographic Details
Main Authors: Ana Beatriz S. Sampaio, Mônica Shigemi S. Mori, Lorena C. Albernaz, Laila S. Espindola, Carlos Eduardo M. Salvador, Carlos Kleber Z. Andrade
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Catalysts
Subjects:
isoxazolone
photochemistry
continuous flow
larvicidal activity
Online Access:https://www.mdpi.com/2073-4344/13/3/518

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https://www.mdpi.com/2073-4344/13/3/518

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