Sleep-related declarative memory consolidation and verbal replay during sleep talking in patients with REM sleep behavior disorder.
OBJECTIVE: To determine if sleep talkers with REM sleep behavior disorder (RBD) would utter during REM sleep sentences learned before sleep, and to evaluate their verbal memory consolidation during sleep. METHODS: Eighteen patients with RBD and 10 controls performed two verbal memory tasks (16 words...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3862769?pdf=render |
| _version_ | 1818291549315792896 |
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| author | Ginevra Uguccioni Olivier Pallanca Jean-Louis Golmard Pauline Dodet Bastien Herlin Smaranda Leu-Semenescu Isabelle Arnulf |
| author_facet | Ginevra Uguccioni Olivier Pallanca Jean-Louis Golmard Pauline Dodet Bastien Herlin Smaranda Leu-Semenescu Isabelle Arnulf |
| author_sort | Ginevra Uguccioni |
| collection | DOAJ |
| description | OBJECTIVE: To determine if sleep talkers with REM sleep behavior disorder (RBD) would utter during REM sleep sentences learned before sleep, and to evaluate their verbal memory consolidation during sleep. METHODS: Eighteen patients with RBD and 10 controls performed two verbal memory tasks (16 words from the Free and Cued Selective Reminding Test and a 220-263 word long modified Story Recall Test) in the evening, followed by nocturnal video-polysomnography and morning recall (night-time consolidation). In 9 patients with RBD, daytime consolidation (morning learning/recall, evening recall) was also evaluated with the modified Story Recall Test in a cross-over order. Two RBD patients with dementia were studied separately. Sleep talking was recorded using video-polysomnography, and the utterances were compared to the studied texts by two external judges. RESULTS: Sleep-related verbal memory consolidation was maintained in patients with RBD (+24±36% words) as in controls (+9±18%, p=0.3). The two demented patients with RBD also exhibited excellent nighttime consolidation. The post-sleep performance was unrelated to the sleep measures (including continuity, stages, fragmentation and apnea-hypopnea index). Daytime consolidation (-9±19%) was worse than night-time consolidation (+29±45%, p=0.03) in the subgroup of 9 patients with RBD. Eleven patients with RBD spoke during REM sleep and pronounced a median of 20 words, which represented 0.0003% of sleep with spoken language. A single patient uttered a sentence that was judged to be semantically (but not literally) related to the text learned before sleep. CONCLUSION: Verbal declarative memory normally consolidates during sleep in patients with RBD. The incorporation of learned material within REM sleep-associated sleep talking in one patient (unbeknownst to himself) at the semantic level suggests a replay at a highly cognitive creative level. |
| first_indexed | 2024-12-13T02:45:50Z |
| format | Article |
| id | doaj.art-b47c378412da41b69a1fb6b71ff451f6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T02:45:50Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b47c378412da41b69a1fb6b71ff451f62022-12-22T00:02:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01812e8335210.1371/journal.pone.0083352Sleep-related declarative memory consolidation and verbal replay during sleep talking in patients with REM sleep behavior disorder.Ginevra UguccioniOlivier PallancaJean-Louis GolmardPauline DodetBastien HerlinSmaranda Leu-SemenescuIsabelle ArnulfOBJECTIVE: To determine if sleep talkers with REM sleep behavior disorder (RBD) would utter during REM sleep sentences learned before sleep, and to evaluate their verbal memory consolidation during sleep. METHODS: Eighteen patients with RBD and 10 controls performed two verbal memory tasks (16 words from the Free and Cued Selective Reminding Test and a 220-263 word long modified Story Recall Test) in the evening, followed by nocturnal video-polysomnography and morning recall (night-time consolidation). In 9 patients with RBD, daytime consolidation (morning learning/recall, evening recall) was also evaluated with the modified Story Recall Test in a cross-over order. Two RBD patients with dementia were studied separately. Sleep talking was recorded using video-polysomnography, and the utterances were compared to the studied texts by two external judges. RESULTS: Sleep-related verbal memory consolidation was maintained in patients with RBD (+24±36% words) as in controls (+9±18%, p=0.3). The two demented patients with RBD also exhibited excellent nighttime consolidation. The post-sleep performance was unrelated to the sleep measures (including continuity, stages, fragmentation and apnea-hypopnea index). Daytime consolidation (-9±19%) was worse than night-time consolidation (+29±45%, p=0.03) in the subgroup of 9 patients with RBD. Eleven patients with RBD spoke during REM sleep and pronounced a median of 20 words, which represented 0.0003% of sleep with spoken language. A single patient uttered a sentence that was judged to be semantically (but not literally) related to the text learned before sleep. CONCLUSION: Verbal declarative memory normally consolidates during sleep in patients with RBD. The incorporation of learned material within REM sleep-associated sleep talking in one patient (unbeknownst to himself) at the semantic level suggests a replay at a highly cognitive creative level.http://europepmc.org/articles/PMC3862769?pdf=render |
| spellingShingle | Ginevra Uguccioni Olivier Pallanca Jean-Louis Golmard Pauline Dodet Bastien Herlin Smaranda Leu-Semenescu Isabelle Arnulf Sleep-related declarative memory consolidation and verbal replay during sleep talking in patients with REM sleep behavior disorder. PLoS ONE |
| title | Sleep-related declarative memory consolidation and verbal replay during sleep talking in patients with REM sleep behavior disorder. |
| title_full | Sleep-related declarative memory consolidation and verbal replay during sleep talking in patients with REM sleep behavior disorder. |
| title_fullStr | Sleep-related declarative memory consolidation and verbal replay during sleep talking in patients with REM sleep behavior disorder. |
| title_full_unstemmed | Sleep-related declarative memory consolidation and verbal replay during sleep talking in patients with REM sleep behavior disorder. |
| title_short | Sleep-related declarative memory consolidation and verbal replay during sleep talking in patients with REM sleep behavior disorder. |
| title_sort | sleep related declarative memory consolidation and verbal replay during sleep talking in patients with rem sleep behavior disorder |
| url | http://europepmc.org/articles/PMC3862769?pdf=render |
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