Steroidal Pyrimidines and Dihydrotriazines as Novel Classes of Anticancer Agents against Hormone-Dependent Breast Cancer Cells

Steroidal Pyrimidines and Dihydrotriazines as Novel Classes of Anticancer Agents against Hormone-Dependent Breast Cancer Cells

Most breast and prostate tumors are hormone-dependent, making it possible to use hormone therapy in patients with these tumors. The design of effective endocrine drugs that block the growth of tumors and have no severe side effects is a challenge. Thereupon, synthetic steroids are promising therapeu...

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Bibliographic Details
Main Authors: Alexander M. Scherbakov, Alexander V. Komkov, Anna S. Komendantova, Margarita A. Yastrebova, Olga E. Andreeva, Valerii Z. Shirinian, Alakananda Hajra, Igor V. Zavarzin, Yulia A. Volkova
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Pharmacology
Subjects:
heterosteroids
steroidal pyrimidines
steroidal dihydrotriazines
breast cancer
prostate cancer
estrogen receptor α
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00979/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00979/full

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