Effect of transfused donor and autoerythrocytes on the oncological outcomes of surgical treatment in patients with renal cell carcinoma with tumor-related venous thrombosis: observational study
Background. The only effective treatment for renal cell carcinoma with tumor inferior vena cava (IVC) thrombosis is surgery. Nephrectomy with thrombectomy (NETE) is usually associated with clinically significant blood loss. The role of blood-sparing methods using autoerythrocyte reinfusion device (A...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IP Habib O.N.
2023-05-01
|
| Series: | Современная онкология |
| Subjects: | |
| Online Access: | https://modernonco.orscience.ru/1815-1434/article/viewFile/181617/pdf |
| _version_ | 1797807469808844800 |
|---|---|
| author | Maria I. Volkova Pavel I. Feoktistov Adilet K. Begaliev Alexandr R. Shin Vsevolod B. Matveev Aleksey O. Prikhodchenko |
| author_facet | Maria I. Volkova Pavel I. Feoktistov Adilet K. Begaliev Alexandr R. Shin Vsevolod B. Matveev Aleksey O. Prikhodchenko |
| author_sort | Maria I. Volkova |
| collection | DOAJ |
| description | Background. The only effective treatment for renal cell carcinoma with tumor inferior vena cava (IVC) thrombosis is surgery. Nephrectomy with thrombectomy (NETE) is usually associated with clinically significant blood loss. The role of blood-sparing methods using autoerythrocyte reinfusion device (ARD) or replacement of blood loss with donor erythrocytes (DE) on the outcomes of NETE has not been well studied.
Aim. To study the rate of hemostasis disorders with intraoperative ARD use, as well as the effect of ARD and DE transfusions on specific (SS), relapse-free (RFS), and progression-free (PFS) survival of patients with renal cell carcinoma (RCC) after NETE.
Materials and methods. The observational study included medical data of 507 patients with RCC and tumor IVC thrombosis operated after NETE. The median volume of blood loss was 4000 [20006500] mL. In 312 (61.5%) patients, ARD without a leukocyte filter was used to compensate for blood loss (median volume of reinfused autoerythrocytes AE was 1140 [700; 1900] mL). Transfusion of DE was required in 387 (76.3%) cases; the median number of DE transfused doses was 3 [1; 5]; 475 (93.7%) patients were discharged from the hospital. The median follow-up of all surviving patients was 24 (1189) months.
Results. Indications for blood transfusions (DE and AE) were directly correlated to the pN (r=0.101; p=0.024) and pT (r=0.091; p=0.040) categories, respectively. The use of AE had no significant effect on the rate of hemostasis disorders and coagulopathic complications compared to other methods of blood loss replacement: 6.8% (21/311) vs 4.7% (9/193), p=0.227; 5.1% (16/311) vs 4.1% (8/193), p=0.394, respectively. ARD had no effect on SS, RFS (after radical surgery), and PFS (after cytoreductive surgery) after NETE. There was a reduction of SS in patients who received DE transfusions compared with those who did not (hazard ratio 0.4; 95% confidence interval 0.10.9; p=0.048). The effects of DE transfusions on RFS and PFS were not identified.
Conclusion. Intraoperative ARD use is an effective and safe method of correcting anemia, which does not increase the risk of coagulopathic complications or decrease survival rates. The non-use of the leukocyte filter during AE preparation does not worsen the medium-term oncological results of RCC surgical treatment with tumor IVC thrombosis. The effect of DE transfusion on the survival of RCC patients after NETE requires further research. |
| first_indexed | 2024-03-13T06:22:59Z |
| format | Article |
| id | doaj.art-b483e4f2b0b049c69c8b2c5de97da2dc |
| institution | Directory Open Access Journal |
| issn | 1815-1434 1815-1442 |
| language | Russian |
| last_indexed | 2024-03-13T06:22:59Z |
| publishDate | 2023-05-01 |
| publisher | IP Habib O.N. |
| record_format | Article |
| series | Современная онкология |
| spelling | doaj.art-b483e4f2b0b049c69c8b2c5de97da2dc2023-06-09T14:24:08ZrusIP Habib O.N.Современная онкология1815-14341815-14422023-05-0125113313910.26442/18151434.2023.1.20210379475Effect of transfused donor and autoerythrocytes on the oncological outcomes of surgical treatment in patients with renal cell carcinoma with tumor-related venous thrombosis: observational studyMaria I. Volkova0https://orcid.org/0000-0001-7754-6624Pavel I. Feoktistov1https://orcid.org/0000-0001-6024-5817Adilet K. Begaliev2https://orcid.org/0000-0002-0755-7421Alexandr R. Shin3https://orcid.org/0000-0002-3595-3472Vsevolod B. Matveev4https://orcid.org/0000-0001-7748-9527Aleksey O. Prikhodchenko5https://orcid.org/0000-0002-4770-0034Russian Medical Academy of Continuous Professional EducationBlokhin National Medical Research Center of OncologyCity Clinical Oncology Hospital №1Blokhin National Medical Research Center of OncologyBlokhin National Medical Research Center of OncologyScientific and Educational Center “Eurasian Cancer Program EAFO”Background. The only effective treatment for renal cell carcinoma with tumor inferior vena cava (IVC) thrombosis is surgery. Nephrectomy with thrombectomy (NETE) is usually associated with clinically significant blood loss. The role of blood-sparing methods using autoerythrocyte reinfusion device (ARD) or replacement of blood loss with donor erythrocytes (DE) on the outcomes of NETE has not been well studied. Aim. To study the rate of hemostasis disorders with intraoperative ARD use, as well as the effect of ARD and DE transfusions on specific (SS), relapse-free (RFS), and progression-free (PFS) survival of patients with renal cell carcinoma (RCC) after NETE. Materials and methods. The observational study included medical data of 507 patients with RCC and tumor IVC thrombosis operated after NETE. The median volume of blood loss was 4000 [20006500] mL. In 312 (61.5%) patients, ARD without a leukocyte filter was used to compensate for blood loss (median volume of reinfused autoerythrocytes AE was 1140 [700; 1900] mL). Transfusion of DE was required in 387 (76.3%) cases; the median number of DE transfused doses was 3 [1; 5]; 475 (93.7%) patients were discharged from the hospital. The median follow-up of all surviving patients was 24 (1189) months. Results. Indications for blood transfusions (DE and AE) were directly correlated to the pN (r=0.101; p=0.024) and pT (r=0.091; p=0.040) categories, respectively. The use of AE had no significant effect on the rate of hemostasis disorders and coagulopathic complications compared to other methods of blood loss replacement: 6.8% (21/311) vs 4.7% (9/193), p=0.227; 5.1% (16/311) vs 4.1% (8/193), p=0.394, respectively. ARD had no effect on SS, RFS (after radical surgery), and PFS (after cytoreductive surgery) after NETE. There was a reduction of SS in patients who received DE transfusions compared with those who did not (hazard ratio 0.4; 95% confidence interval 0.10.9; p=0.048). The effects of DE transfusions on RFS and PFS were not identified. Conclusion. Intraoperative ARD use is an effective and safe method of correcting anemia, which does not increase the risk of coagulopathic complications or decrease survival rates. The non-use of the leukocyte filter during AE preparation does not worsen the medium-term oncological results of RCC surgical treatment with tumor IVC thrombosis. The effect of DE transfusion on the survival of RCC patients after NETE requires further research.https://modernonco.orscience.ru/1815-1434/article/viewFile/181617/pdfrenal cell carcinomanephrectomythrombectomycell-saverautoerythrocyte reinfusion devicedonor erythrocytessurvival |
| spellingShingle | Maria I. Volkova Pavel I. Feoktistov Adilet K. Begaliev Alexandr R. Shin Vsevolod B. Matveev Aleksey O. Prikhodchenko Effect of transfused donor and autoerythrocytes on the oncological outcomes of surgical treatment in patients with renal cell carcinoma with tumor-related venous thrombosis: observational study Современная онкология renal cell carcinoma nephrectomy thrombectomy cell-saver autoerythrocyte reinfusion device donor erythrocytes survival |
| title | Effect of transfused donor and autoerythrocytes on the oncological outcomes of surgical treatment in patients with renal cell carcinoma with tumor-related venous thrombosis: observational study |
| title_full | Effect of transfused donor and autoerythrocytes on the oncological outcomes of surgical treatment in patients with renal cell carcinoma with tumor-related venous thrombosis: observational study |
| title_fullStr | Effect of transfused donor and autoerythrocytes on the oncological outcomes of surgical treatment in patients with renal cell carcinoma with tumor-related venous thrombosis: observational study |
| title_full_unstemmed | Effect of transfused donor and autoerythrocytes on the oncological outcomes of surgical treatment in patients with renal cell carcinoma with tumor-related venous thrombosis: observational study |
| title_short | Effect of transfused donor and autoerythrocytes on the oncological outcomes of surgical treatment in patients with renal cell carcinoma with tumor-related venous thrombosis: observational study |
| title_sort | effect of transfused donor and autoerythrocytes on the oncological outcomes of surgical treatment in patients with renal cell carcinoma with tumor related venous thrombosis observational study |
| topic | renal cell carcinoma nephrectomy thrombectomy cell-saver autoerythrocyte reinfusion device donor erythrocytes survival |
| url | https://modernonco.orscience.ru/1815-1434/article/viewFile/181617/pdf |
| work_keys_str_mv | AT mariaivolkova effectoftransfuseddonorandautoerythrocytesontheoncologicaloutcomesofsurgicaltreatmentinpatientswithrenalcellcarcinomawithtumorrelatedvenousthrombosisobservationalstudy AT pavelifeoktistov effectoftransfuseddonorandautoerythrocytesontheoncologicaloutcomesofsurgicaltreatmentinpatientswithrenalcellcarcinomawithtumorrelatedvenousthrombosisobservationalstudy AT adiletkbegaliev effectoftransfuseddonorandautoerythrocytesontheoncologicaloutcomesofsurgicaltreatmentinpatientswithrenalcellcarcinomawithtumorrelatedvenousthrombosisobservationalstudy AT alexandrrshin effectoftransfuseddonorandautoerythrocytesontheoncologicaloutcomesofsurgicaltreatmentinpatientswithrenalcellcarcinomawithtumorrelatedvenousthrombosisobservationalstudy AT vsevolodbmatveev effectoftransfuseddonorandautoerythrocytesontheoncologicaloutcomesofsurgicaltreatmentinpatientswithrenalcellcarcinomawithtumorrelatedvenousthrombosisobservationalstudy AT alekseyoprikhodchenko effectoftransfuseddonorandautoerythrocytesontheoncologicaloutcomesofsurgicaltreatmentinpatientswithrenalcellcarcinomawithtumorrelatedvenousthrombosisobservationalstudy |