Association between vitamin D and latent tuberculosis infection in the United States: NHANES, 2011–2012
Cheng-Yi Wang,1,* Yin-Lan Hu,2,* Ya-Hui Wang,3 Cheng-Hsin Chen,1 Chih-Cheng Lai,4 Kun-Lun Huang51Department of Internal Medicine, Cardinal Tien Hospital and School of Medicine, College of Medicine, Fu-jen Catholic University, New Taipei City, Taiwan; 2Department of Dentistry, Cardi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-07-01
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| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/association-between-vitamin-d-and-latent-tuberculosis-infection-in-the-peer-reviewed-article-IDR |
| _version_ | 1828858790743638016 |
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| author | Wang CY Hu YL Wang YH Chen CH Lai CC Huang KL |
| author_facet | Wang CY Hu YL Wang YH Chen CH Lai CC Huang KL |
| author_sort | Wang CY |
| collection | DOAJ |
| description | Cheng-Yi Wang,1,* Yin-Lan Hu,2,* Ya-Hui Wang,3 Cheng-Hsin Chen,1 Chih-Cheng Lai,4 Kun-Lun Huang51Department of Internal Medicine, Cardinal Tien Hospital and School of Medicine, College of Medicine, Fu-jen Catholic University, New Taipei City, Taiwan; 2Department of Dentistry, Cardinal Tien Hospital and School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; 3Medical Research Center, Cardinal Tien Hospital and School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; 4Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Taiwan; 5Division of Pulmonary Medicine, Tri-service General Hospital, Institute of Undersea and Hyperbaric Medicine, National Defense Medical Center, Taipei, Taiwan*These authors contributed equally to this workBackground: Latent tuberculosis infection (LTBI) is a precursor of active tuberculosis diseases and an important issue in the United States and worldwide. The association between vitamin D deficiency and LTBI is poorly understood.Methods: From 2011 to 2012, the National Health and Nutrition Examination Survey (NHANES) assessed LTBI (according to tuberculin skin testing and QuantiFERON®,-TB Gold In-Tube) and measured serum levels of vitamin D. We evaluated the association between LTBI and vitamin D using multivariate logistic regression models adjusted for known confounders.Results: The LTBI group had a lower 25-hydroxyvitamin D [25(OH)D] level than the non-LTBI group (p=0.0012). The adjusted risk of LTBI was significantly higher among participants with serum 25(OH)D levels <12 ng/ml (adjusted OR [aOR], 2.27; 95% CI, 1.40–3.66) and 12–19 ng/ml (aOR, 1.75; 95% CI, 1.25–2.46) compared to those with a level ≥30 ng/ml. The higher risk of LTBI among the participants with serum 25(OH)D levels <12 ng/ml and 12–19 ng/ml remained unchanged in both male and summer season subgroups.Conclusions: A low serum 25(OH)D level was significantly associated with the risk of LTBI in this US cohort.Keywords: latent tuberculosis infection, NHANES, risk, vitamin D |
| first_indexed | 2024-12-13T02:04:45Z |
| format | Article |
| id | doaj.art-b484ab3ea2c343c9a5c81ac36a6b09bb |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-13T02:04:45Z |
| publishDate | 2019-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-b484ab3ea2c343c9a5c81ac36a6b09bb2022-12-22T00:03:11ZengDove Medical PressInfection and Drug Resistance1178-69732019-07-01Volume 122251225747279Association between vitamin D and latent tuberculosis infection in the United States: NHANES, 2011–2012Wang CYHu YLWang YHChen CHLai CCHuang KLCheng-Yi Wang,1,* Yin-Lan Hu,2,* Ya-Hui Wang,3 Cheng-Hsin Chen,1 Chih-Cheng Lai,4 Kun-Lun Huang51Department of Internal Medicine, Cardinal Tien Hospital and School of Medicine, College of Medicine, Fu-jen Catholic University, New Taipei City, Taiwan; 2Department of Dentistry, Cardinal Tien Hospital and School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; 3Medical Research Center, Cardinal Tien Hospital and School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; 4Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Taiwan; 5Division of Pulmonary Medicine, Tri-service General Hospital, Institute of Undersea and Hyperbaric Medicine, National Defense Medical Center, Taipei, Taiwan*These authors contributed equally to this workBackground: Latent tuberculosis infection (LTBI) is a precursor of active tuberculosis diseases and an important issue in the United States and worldwide. The association between vitamin D deficiency and LTBI is poorly understood.Methods: From 2011 to 2012, the National Health and Nutrition Examination Survey (NHANES) assessed LTBI (according to tuberculin skin testing and QuantiFERON®,-TB Gold In-Tube) and measured serum levels of vitamin D. We evaluated the association between LTBI and vitamin D using multivariate logistic regression models adjusted for known confounders.Results: The LTBI group had a lower 25-hydroxyvitamin D [25(OH)D] level than the non-LTBI group (p=0.0012). The adjusted risk of LTBI was significantly higher among participants with serum 25(OH)D levels <12 ng/ml (adjusted OR [aOR], 2.27; 95% CI, 1.40–3.66) and 12–19 ng/ml (aOR, 1.75; 95% CI, 1.25–2.46) compared to those with a level ≥30 ng/ml. The higher risk of LTBI among the participants with serum 25(OH)D levels <12 ng/ml and 12–19 ng/ml remained unchanged in both male and summer season subgroups.Conclusions: A low serum 25(OH)D level was significantly associated with the risk of LTBI in this US cohort.Keywords: latent tuberculosis infection, NHANES, risk, vitamin Dhttps://www.dovepress.com/association-between-vitamin-d-and-latent-tuberculosis-infection-in-the-peer-reviewed-article-IDRLatent tuberculosis infectionNHANESRiskVitamin D |
| spellingShingle | Wang CY Hu YL Wang YH Chen CH Lai CC Huang KL Association between vitamin D and latent tuberculosis infection in the United States: NHANES, 2011–2012 Infection and Drug Resistance Latent tuberculosis infection NHANES Risk Vitamin D |
| title | Association between vitamin D and latent tuberculosis infection in the United States: NHANES, 2011–2012 |
| title_full | Association between vitamin D and latent tuberculosis infection in the United States: NHANES, 2011–2012 |
| title_fullStr | Association between vitamin D and latent tuberculosis infection in the United States: NHANES, 2011–2012 |
| title_full_unstemmed | Association between vitamin D and latent tuberculosis infection in the United States: NHANES, 2011–2012 |
| title_short | Association between vitamin D and latent tuberculosis infection in the United States: NHANES, 2011–2012 |
| title_sort | association between vitamin d and latent tuberculosis infection in the united states nhanes 2011 ndash 2012 |
| topic | Latent tuberculosis infection NHANES Risk Vitamin D |
| url | https://www.dovepress.com/association-between-vitamin-d-and-latent-tuberculosis-infection-in-the-peer-reviewed-article-IDR |
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