CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model
Tau-mediated neurodegeneration is driven by disease-activated microglia and suppressed by their pharmacological blockade. The authors identified drug dose- and sex-dependent residual microglial phenotypes, neuronal excitotoxicity, and animal survival.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35753-w |
| _version_ | 1828063714130001920 |
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| author | Noah R. Johnson Peng Yuan Erika Castillo T. Peter Lopez Weizhou Yue Annalise Bond Brianna M. Rivera Miranda C. Sullivan Masakazu Hirouchi Kurt Giles Atsushi Aoyagi Carlo Condello |
| author_facet | Noah R. Johnson Peng Yuan Erika Castillo T. Peter Lopez Weizhou Yue Annalise Bond Brianna M. Rivera Miranda C. Sullivan Masakazu Hirouchi Kurt Giles Atsushi Aoyagi Carlo Condello |
| author_sort | Noah R. Johnson |
| collection | DOAJ |
| description | Tau-mediated neurodegeneration is driven by disease-activated microglia and suppressed by their pharmacological blockade. The authors identified drug dose- and sex-dependent residual microglial phenotypes, neuronal excitotoxicity, and animal survival. |
| first_indexed | 2024-04-10T22:47:26Z |
| format | Article |
| id | doaj.art-b48523c2ca3f4e85a7a80f256c64823a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T22:47:26Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b48523c2ca3f4e85a7a80f256c64823a2023-01-15T12:15:33ZengNature PortfolioNature Communications2041-17232023-01-0114112310.1038/s41467-022-35753-wCSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse modelNoah R. Johnson0Peng Yuan1Erika Castillo2T. Peter Lopez3Weizhou Yue4Annalise Bond5Brianna M. Rivera6Miranda C. Sullivan7Masakazu Hirouchi8Kurt Giles9Atsushi Aoyagi10Carlo Condello11Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of CaliforniaInstitute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of CaliforniaInstitute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of CaliforniaInstitute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of CaliforniaInstitute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of CaliforniaInstitute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of CaliforniaInstitute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of CaliforniaInstitute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of CaliforniaInstitute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of CaliforniaInstitute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of CaliforniaInstitute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of CaliforniaInstitute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of CaliforniaTau-mediated neurodegeneration is driven by disease-activated microglia and suppressed by their pharmacological blockade. The authors identified drug dose- and sex-dependent residual microglial phenotypes, neuronal excitotoxicity, and animal survival.https://doi.org/10.1038/s41467-022-35753-w |
| spellingShingle | Noah R. Johnson Peng Yuan Erika Castillo T. Peter Lopez Weizhou Yue Annalise Bond Brianna M. Rivera Miranda C. Sullivan Masakazu Hirouchi Kurt Giles Atsushi Aoyagi Carlo Condello CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model Nature Communications |
| title | CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model |
| title_full | CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model |
| title_fullStr | CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model |
| title_full_unstemmed | CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model |
| title_short | CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model |
| title_sort | csf1r inhibitors induce a sex specific resilient microglial phenotype and functional rescue in a tauopathy mouse model |
| url | https://doi.org/10.1038/s41467-022-35753-w |
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