Microgravity and the intervertebral disc: The impact of space conditions on the biomechanics of the spine
The environmental conditions to which astronauts and other military pilots are subjected represent a unique example for understanding and studying the biomechanical events that regulate the functioning of the human body. In particular, microgravity has shown a significant impact on various biologica...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1124991/full |
| _version_ | 1797871393950400512 |
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| author | Giovanni Marfia Giovanni Marfia Laura Guarnaccia Stefania Elena Navone Antonella Ampollini Melissa Balsamo Francesca Benelli Chiara Gaudino Emanuele Garzia Claudia Fratocchi Claudia Di Murro Gianfranco Kim Ligarotti Carmelo Campanella Angelo Landolfi Pietro Perelli Marco Locatelli Marco Locatelli Giuseppe Ciniglio Appiani |
| author_facet | Giovanni Marfia Giovanni Marfia Laura Guarnaccia Stefania Elena Navone Antonella Ampollini Melissa Balsamo Francesca Benelli Chiara Gaudino Emanuele Garzia Claudia Fratocchi Claudia Di Murro Gianfranco Kim Ligarotti Carmelo Campanella Angelo Landolfi Pietro Perelli Marco Locatelli Marco Locatelli Giuseppe Ciniglio Appiani |
| author_sort | Giovanni Marfia |
| collection | DOAJ |
| description | The environmental conditions to which astronauts and other military pilots are subjected represent a unique example for understanding and studying the biomechanical events that regulate the functioning of the human body. In particular, microgravity has shown a significant impact on various biological systems, such as the cardiovascular system, immune system, endocrine system, and, last but not least, musculoskeletal system. Among the potential risks of flying, low back pain (LBP) has a high incidence among astronauts and military pilots, and it is often associated with intervertebral disc degeneration events. The mechanisms of degeneration determine the loss of structural and functional integrity and are accompanied by the aberrant production of pro-inflammatory mediators that exacerbate the degenerative environment, contributing to the onset of pain. In the present work, the mechanisms of disc degeneration, the conditions of microgravity, and their association have been discussed in order to identify possible molecular mechanisms underlying disc degeneration and the related clinical manifestations in order to develop a model of prevention to maintain health and performance of air- and space-travelers. The focus on microgravity also allows the development of new proofs of concept with potential therapeutic implications. |
| first_indexed | 2024-04-10T00:42:09Z |
| format | Article |
| id | doaj.art-b48c5a1c3f3645519dbe66047cd504ae |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-10T00:42:09Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-b48c5a1c3f3645519dbe66047cd504ae2023-03-14T05:37:57ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-03-011410.3389/fphys.2023.11249911124991Microgravity and the intervertebral disc: The impact of space conditions on the biomechanics of the spineGiovanni Marfia0Giovanni Marfia1Laura Guarnaccia2Stefania Elena Navone3Antonella Ampollini4Melissa Balsamo5Francesca Benelli6Chiara Gaudino7Emanuele Garzia8Claudia Fratocchi9Claudia Di Murro10Gianfranco Kim Ligarotti11Carmelo Campanella12Angelo Landolfi13Pietro Perelli14Marco Locatelli15Marco Locatelli16Giuseppe Ciniglio Appiani17Laboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyClinical Pathology Unit, Istituto di Medicina Aerospaziale “A. Mosso”, Aeronautica Militare, Milan, ItalyLaboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyLaboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyLaboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyLaboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyLaboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Neuroradiology, Azienda Ospedaliero-Universitaria Policlinico Umberto I, Rome, ItalyIstituto di Medicina Aerospaziale “A. Mosso”, Aeronautica Militare, Milan, ItalyClinical Pathology Unit, Istituto di Medicina Aerospaziale “A. Mosso”, Aeronautica Militare, Milan, ItalyClinical Pathology Unit, Istituto di Medicina Aerospaziale “A. Mosso”, Aeronautica Militare, Milan, ItalyIstituto di Medicina Aerospaziale “A. Mosso”, Aeronautica Militare, Milan, ItalyIstituto di Medicina Aerospaziale “Aldo Di Loreto”, Aeronautica Militare, Rome, ItalyItalian Air Force Logistic Command, Rome, ItalyItalian Air Force Logistic Command, Rome, ItalyLaboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Medical-Surgical Physiopathology and Transplantation, University of Milan, Milan, ItalyItalian Air Force Logistic Command, Rome, ItalyThe environmental conditions to which astronauts and other military pilots are subjected represent a unique example for understanding and studying the biomechanical events that regulate the functioning of the human body. In particular, microgravity has shown a significant impact on various biological systems, such as the cardiovascular system, immune system, endocrine system, and, last but not least, musculoskeletal system. Among the potential risks of flying, low back pain (LBP) has a high incidence among astronauts and military pilots, and it is often associated with intervertebral disc degeneration events. The mechanisms of degeneration determine the loss of structural and functional integrity and are accompanied by the aberrant production of pro-inflammatory mediators that exacerbate the degenerative environment, contributing to the onset of pain. In the present work, the mechanisms of disc degeneration, the conditions of microgravity, and their association have been discussed in order to identify possible molecular mechanisms underlying disc degeneration and the related clinical manifestations in order to develop a model of prevention to maintain health and performance of air- and space-travelers. The focus on microgravity also allows the development of new proofs of concept with potential therapeutic implications.https://www.frontiersin.org/articles/10.3389/fphys.2023.1124991/fullmicrogravityintervertebral discdisc degenerationlow back painspace |
| spellingShingle | Giovanni Marfia Giovanni Marfia Laura Guarnaccia Stefania Elena Navone Antonella Ampollini Melissa Balsamo Francesca Benelli Chiara Gaudino Emanuele Garzia Claudia Fratocchi Claudia Di Murro Gianfranco Kim Ligarotti Carmelo Campanella Angelo Landolfi Pietro Perelli Marco Locatelli Marco Locatelli Giuseppe Ciniglio Appiani Microgravity and the intervertebral disc: The impact of space conditions on the biomechanics of the spine Frontiers in Physiology microgravity intervertebral disc disc degeneration low back pain space |
| title | Microgravity and the intervertebral disc: The impact of space conditions on the biomechanics of the spine |
| title_full | Microgravity and the intervertebral disc: The impact of space conditions on the biomechanics of the spine |
| title_fullStr | Microgravity and the intervertebral disc: The impact of space conditions on the biomechanics of the spine |
| title_full_unstemmed | Microgravity and the intervertebral disc: The impact of space conditions on the biomechanics of the spine |
| title_short | Microgravity and the intervertebral disc: The impact of space conditions on the biomechanics of the spine |
| title_sort | microgravity and the intervertebral disc the impact of space conditions on the biomechanics of the spine |
| topic | microgravity intervertebral disc disc degeneration low back pain space |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1124991/full |
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