Modelisation of the regulation of protein synthesis following fertilization in sea urchin shows requirement of two processes: a destabilization of eIF4E:4E-BP complex and a great stimulation of the 4E-BP-degradation mechanism, both rapamycin-sensitive.

Modelisation of the regulation of protein synthesis following fertilization in sea urchin shows requirement of two processes: a destabilization of eIF4E:4E-BP complex and a great stimulation of the 4E-BP-degradation mechanism, both rapamycin-sensitive.

Fertilization of sea urchin eggs involves an increase in protein synthesis associated with a decrease in the amount of the translation initiation inhibitor 4E-BP. A highly simple reaction model for the regulation of protein synthesis was built and was used to simulate the physiological changes in th...

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Bibliographic Details
Main Authors: Sébastien eLaurent, Adrien eRichard, Odile eMulner-Lorillon, Julia eMorales, Didier eFlament, Virginie eGlippa, Jérémie eBourdon, Pauline eGosselin, Anne eSiegel, Patrick eCormier, Robert eBellé
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Genetics
Subjects:
translational control
sea urchin embryos
mechanisms of fertilization
deterministic model
translation simulation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00117/full

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