Investigation of hematotoxic effect of nano ZnO, nano Fe3O4 and nano SiO2 in vitro
Objective(s): Evaluation of nanomaterials interaction with blood ingredients is a part of preclinical risk assessment of newly-synthesized materials, especially for nano-sized pharmaceuticals which are intravenously administrated. The red blood cells (RBCs) are susceptible to oxidative stress damage...
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| Format: | Article |
| Language: | English |
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Iranian Society of Nanomedicine
2017-04-01
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| Series: | Nanomedicine Research Journal |
| Online Access: | http://www.nanomedicine-rj.com/article_25344_0707765de87c69eb6d1fb2b01aed5e17.pdf |
| _version_ | 1811315798035136512 |
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| author | Mohammad Kazem Koohi Marzie Hejazy Davood Najafi Seyed Mehdi Sajadi |
| author_facet | Mohammad Kazem Koohi Marzie Hejazy Davood Najafi Seyed Mehdi Sajadi |
| author_sort | Mohammad Kazem Koohi |
| collection | DOAJ |
| description | Objective(s): Evaluation of nanomaterials interaction with blood ingredients is a part of preclinical risk assessment of newly-synthesized materials, especially for nano-sized pharmaceuticals which are intravenously administrated. The red blood cells (RBCs) are susceptible to oxidative stress damage. This study was designed to evaluate induced oxidative hematotoxic effect of nano ZnO, Fe3O4, and nano SiO2 on human red blood cells in vitro. Methods: Blood samples were collected from healthy male volunteers. RBCs were exposed to different concentrations (50, 100, 250mg/ml) of nano ZnO, nano Fe3O4, and nano SiO2 at 4°C for 24hours. Lipid peroxidation and intracellular Glutathione (GSH) level were studied as the biomarkers of oxidative stress. Results: The results showed that the lipid peroxidation had significantly increased. However, after exposure to nanoparticles, the GSH level of RBCs considerably decreased compared to the controls (p |
| first_indexed | 2024-04-13T11:36:31Z |
| format | Article |
| id | doaj.art-b48eaaa4859f433095553f2f69ca828b |
| institution | Directory Open Access Journal |
| issn | 2476-3489 2476-7123 |
| language | English |
| last_indexed | 2024-04-13T11:36:31Z |
| publishDate | 2017-04-01 |
| publisher | Iranian Society of Nanomedicine |
| record_format | Article |
| series | Nanomedicine Research Journal |
| spelling | doaj.art-b48eaaa4859f433095553f2f69ca828b2022-12-22T02:48:25ZengIranian Society of NanomedicineNanomedicine Research Journal2476-34892476-71232017-04-0122939910.22034/nmrj.2017.61955.106425344Investigation of hematotoxic effect of nano ZnO, nano Fe3O4 and nano SiO2 in vitroMohammad Kazem Koohi0Marzie Hejazy1Davood Najafi2Seyed Mehdi Sajadi3Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.Basic Science Department, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, IranFaculty of Veterinary Medicine, University of Tabriz, Tabriz, IranFaculty of Veterinary Medicine, University of Tabriz, Tabriz, IranObjective(s): Evaluation of nanomaterials interaction with blood ingredients is a part of preclinical risk assessment of newly-synthesized materials, especially for nano-sized pharmaceuticals which are intravenously administrated. The red blood cells (RBCs) are susceptible to oxidative stress damage. This study was designed to evaluate induced oxidative hematotoxic effect of nano ZnO, Fe3O4, and nano SiO2 on human red blood cells in vitro. Methods: Blood samples were collected from healthy male volunteers. RBCs were exposed to different concentrations (50, 100, 250mg/ml) of nano ZnO, nano Fe3O4, and nano SiO2 at 4°C for 24hours. Lipid peroxidation and intracellular Glutathione (GSH) level were studied as the biomarkers of oxidative stress. Results: The results showed that the lipid peroxidation had significantly increased. However, after exposure to nanoparticles, the GSH level of RBCs considerably decreased compared to the controls (phttp://www.nanomedicine-rj.com/article_25344_0707765de87c69eb6d1fb2b01aed5e17.pdf |
| spellingShingle | Mohammad Kazem Koohi Marzie Hejazy Davood Najafi Seyed Mehdi Sajadi Investigation of hematotoxic effect of nano ZnO, nano Fe3O4 and nano SiO2 in vitro Nanomedicine Research Journal |
| title | Investigation of hematotoxic effect of nano ZnO, nano Fe3O4 and nano SiO2 in vitro |
| title_full | Investigation of hematotoxic effect of nano ZnO, nano Fe3O4 and nano SiO2 in vitro |
| title_fullStr | Investigation of hematotoxic effect of nano ZnO, nano Fe3O4 and nano SiO2 in vitro |
| title_full_unstemmed | Investigation of hematotoxic effect of nano ZnO, nano Fe3O4 and nano SiO2 in vitro |
| title_short | Investigation of hematotoxic effect of nano ZnO, nano Fe3O4 and nano SiO2 in vitro |
| title_sort | investigation of hematotoxic effect of nano zno nano fe3o4 and nano sio2 in vitro |
| url | http://www.nanomedicine-rj.com/article_25344_0707765de87c69eb6d1fb2b01aed5e17.pdf |
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