Expanding the Utility of Bioinformatic Data for the Full Stereostructural Assignments of Marinolides A and B, 24- and 26-Membered Macrolactones Produced by a Chemically Exceptional Marine-Derived Bacterium

Expanding the Utility of Bioinformatic Data for the Full Stereostructural Assignments of Marinolides A and B, 24- and 26-Membered Macrolactones Produced by a Chemically Exceptional Marine-Derived Bacterium

Marinolides A and B, two new 24- and 26-membered bacterial macrolactones, were isolated from the marine-derived actinobacterium AJS-327 and their stereostructures initially assigned by bioinformatic data analysis. Macrolactones typically possess complex stereochemistry, the assignments of which have...

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Bibliographic Details
Main Authors: Min Cheol Kim, Jaclyn M. Winter, Reiko Cullum, Alexander J. Smith, William Fenical
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Marine Drugs
Subjects:
macrolactone
natural product structure elucidation
bioinformatics
genome mining
modular type I polyketide synthase
Online Access:https://www.mdpi.com/1660-3397/21/6/367

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