Laboratory diagnostic testing for cytomegalovirus infection in solid organ transplant patients
Human cytomegalovirus (CMV) infection, which is one of the most common complications in transplant recipients, increases the risk of graft loss and rejection. Laboratory strategies for diagnosing CMV infection rely on the measurement of viral DNAemia and CMV-specific cell-mediated immunity (CMV-CMI)...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Korean Society for Transplantation
2022-03-01
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| Series: | Korean Journal of Transplantation |
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| Online Access: | http://journaleditor.inforang.com/journal/view.html?doi=10.4285/kjt.22.0001 |
| _version_ | 1797329609840132096 |
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| author | Hyeyoung Lee Eun-Jee Oh |
| author_facet | Hyeyoung Lee Eun-Jee Oh |
| author_sort | Hyeyoung Lee |
| collection | DOAJ |
| description | Human cytomegalovirus (CMV) infection, which is one of the most common complications in transplant recipients, increases the risk of graft loss and rejection. Laboratory strategies for diagnosing CMV infection rely on the measurement of viral DNAemia and CMV-specific cell-mediated immunity (CMV-CMI). The CMV quantitative nucleic acid amplification test (QNAT) enabled the spread of preemptive therapy and prompted recommendations for surveillance, diagnosis, and monitoring. Despite the implementation of the World Health Organization international standard for calibration, variability of QNAT persists due to technical issues. CMV immunoglobulin G serology is the standard method for CMV immune screening of transplant candidates and donors. Assays for CMV-CMI play an important role in helping to predict the risk and to develop an individualized CMV management plan. Genotypic testing for resistance is needed when drug-resistant CMV infection is suspected. Here, we review the state of the art of laboratory tests for CMV infection in solid organ transplantation. |
| first_indexed | 2024-03-08T07:07:02Z |
| format | Article |
| id | doaj.art-b4935000ab354c21abebfa4318e69138 |
| institution | Directory Open Access Journal |
| issn | 2671-8790 |
| language | English |
| last_indexed | 2024-03-08T07:07:02Z |
| publishDate | 2022-03-01 |
| publisher | Korean Society for Transplantation |
| record_format | Article |
| series | Korean Journal of Transplantation |
| spelling | doaj.art-b4935000ab354c21abebfa4318e691382024-02-03T04:18:56ZengKorean Society for TransplantationKorean Journal of Transplantation2671-87902022-03-01361152810.4285/kjt.22.0001kjt.22.0001Laboratory diagnostic testing for cytomegalovirus infection in solid organ transplant patientsHyeyoung Lee0Eun-Jee Oh1Department of Laboratory Medicine, International St. Mary’s Hospital, College of Medicine, Catholic Kwandong University, Incheon, KoreaDepartment of Laboratory Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaHuman cytomegalovirus (CMV) infection, which is one of the most common complications in transplant recipients, increases the risk of graft loss and rejection. Laboratory strategies for diagnosing CMV infection rely on the measurement of viral DNAemia and CMV-specific cell-mediated immunity (CMV-CMI). The CMV quantitative nucleic acid amplification test (QNAT) enabled the spread of preemptive therapy and prompted recommendations for surveillance, diagnosis, and monitoring. Despite the implementation of the World Health Organization international standard for calibration, variability of QNAT persists due to technical issues. CMV immunoglobulin G serology is the standard method for CMV immune screening of transplant candidates and donors. Assays for CMV-CMI play an important role in helping to predict the risk and to develop an individualized CMV management plan. Genotypic testing for resistance is needed when drug-resistant CMV infection is suspected. Here, we review the state of the art of laboratory tests for CMV infection in solid organ transplantation.http://journaleditor.inforang.com/journal/view.html?doi=10.4285/kjt.22.0001transplantation; cytomegalovirus; cell-mediated immunity; serology; viral load |
| spellingShingle | Hyeyoung Lee Eun-Jee Oh Laboratory diagnostic testing for cytomegalovirus infection in solid organ transplant patients Korean Journal of Transplantation transplantation; cytomegalovirus; cell-mediated immunity; serology; viral load |
| title | Laboratory diagnostic testing for cytomegalovirus infection in solid organ transplant patients |
| title_full | Laboratory diagnostic testing for cytomegalovirus infection in solid organ transplant patients |
| title_fullStr | Laboratory diagnostic testing for cytomegalovirus infection in solid organ transplant patients |
| title_full_unstemmed | Laboratory diagnostic testing for cytomegalovirus infection in solid organ transplant patients |
| title_short | Laboratory diagnostic testing for cytomegalovirus infection in solid organ transplant patients |
| title_sort | laboratory diagnostic testing for cytomegalovirus infection in solid organ transplant patients |
| topic | transplantation; cytomegalovirus; cell-mediated immunity; serology; viral load |
| url | http://journaleditor.inforang.com/journal/view.html?doi=10.4285/kjt.22.0001 |
| work_keys_str_mv | AT hyeyounglee laboratorydiagnostictestingforcytomegalovirusinfectioninsolidorgantransplantpatients AT eunjeeoh laboratorydiagnostictestingforcytomegalovirusinfectioninsolidorgantransplantpatients |