Insights on Chemical Crosslinking Strategies for Proteins
Crosslinking of proteins has gained immense significance in the fabrication of biomaterials for various health care applications. Various novel chemical-based strategies are being continuously developed for intra-/inter-molecular crosslinking of proteins to create a network/matrix with desired mecha...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-11-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/23/8124 |
| _version_ | 1797462741419556864 |
|---|---|
| author | Brindha Jayachandran Thansila N Parvin M Mujahid Alam Kaushik Chanda Balamurali MM |
| author_facet | Brindha Jayachandran Thansila N Parvin M Mujahid Alam Kaushik Chanda Balamurali MM |
| author_sort | Brindha Jayachandran |
| collection | DOAJ |
| description | Crosslinking of proteins has gained immense significance in the fabrication of biomaterials for various health care applications. Various novel chemical-based strategies are being continuously developed for intra-/inter-molecular crosslinking of proteins to create a network/matrix with desired mechanical/functional properties without imparting toxicity to the host system. Many materials that are used in biomedical and food packaging industries are prepared by chemical means of crosslinking the proteins, besides the physical or enzymatic means of crosslinking. Such chemical methods utilize the chemical compounds or crosslinkers available from natural sources or synthetically generated with the ability to form covalent/non-covalent bonds with proteins. Such linkages are possible with chemicals like carbodiimides/epoxides, while photo-induced novel chemical crosslinkers are also available. In this review, we have discussed different protein crosslinking strategies under chemical methods, along with the corresponding crosslinking reactions/conditions, material properties and significant applications. |
| first_indexed | 2024-03-09T17:40:58Z |
| format | Article |
| id | doaj.art-b4960612da394aa6adc929c4f9f901bb |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T17:40:58Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b4960612da394aa6adc929c4f9f901bb2023-11-24T11:36:59ZengMDPI AGMolecules1420-30492022-11-012723812410.3390/molecules27238124Insights on Chemical Crosslinking Strategies for ProteinsBrindha Jayachandran0Thansila N Parvin1M Mujahid Alam2Kaushik Chanda3Balamurali MM4Chemistry Division, School of Advanced Sciences, Vellore Institute of Technology, Chennai Campus, Vandalur-Kelambakkam Road, Chennai 600127, IndiaChemistry Division, School of Advanced Sciences, Vellore Institute of Technology, Chennai Campus, Vandalur-Kelambakkam Road, Chennai 600127, IndiaDepartment of Chemistry, College of Science, King Khalid University, P.O. Box 9004, Abha 61413, Saudi ArabiaDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, IndiaChemistry Division, School of Advanced Sciences, Vellore Institute of Technology, Chennai Campus, Vandalur-Kelambakkam Road, Chennai 600127, IndiaCrosslinking of proteins has gained immense significance in the fabrication of biomaterials for various health care applications. Various novel chemical-based strategies are being continuously developed for intra-/inter-molecular crosslinking of proteins to create a network/matrix with desired mechanical/functional properties without imparting toxicity to the host system. Many materials that are used in biomedical and food packaging industries are prepared by chemical means of crosslinking the proteins, besides the physical or enzymatic means of crosslinking. Such chemical methods utilize the chemical compounds or crosslinkers available from natural sources or synthetically generated with the ability to form covalent/non-covalent bonds with proteins. Such linkages are possible with chemicals like carbodiimides/epoxides, while photo-induced novel chemical crosslinkers are also available. In this review, we have discussed different protein crosslinking strategies under chemical methods, along with the corresponding crosslinking reactions/conditions, material properties and significant applications.https://www.mdpi.com/1420-3049/27/23/8124protein crosslinkingchemical crosslinkersprotein materialsbiomaterialsdrug delivery |
| spellingShingle | Brindha Jayachandran Thansila N Parvin M Mujahid Alam Kaushik Chanda Balamurali MM Insights on Chemical Crosslinking Strategies for Proteins Molecules protein crosslinking chemical crosslinkers protein materials biomaterials drug delivery |
| title | Insights on Chemical Crosslinking Strategies for Proteins |
| title_full | Insights on Chemical Crosslinking Strategies for Proteins |
| title_fullStr | Insights on Chemical Crosslinking Strategies for Proteins |
| title_full_unstemmed | Insights on Chemical Crosslinking Strategies for Proteins |
| title_short | Insights on Chemical Crosslinking Strategies for Proteins |
| title_sort | insights on chemical crosslinking strategies for proteins |
| topic | protein crosslinking chemical crosslinkers protein materials biomaterials drug delivery |
| url | https://www.mdpi.com/1420-3049/27/23/8124 |
| work_keys_str_mv | AT brindhajayachandran insightsonchemicalcrosslinkingstrategiesforproteins AT thansilanparvin insightsonchemicalcrosslinkingstrategiesforproteins AT mmujahidalam insightsonchemicalcrosslinkingstrategiesforproteins AT kaushikchanda insightsonchemicalcrosslinkingstrategiesforproteins AT balamuralimm insightsonchemicalcrosslinkingstrategiesforproteins |