Suprascapular nerve injury affects rotator cuff healing: A paired controlled study in a rat model
Purpose: We designed a paired controlled study to investigate the role of the suprascapular nerve (SSN) in rotator cuff healing using a rat tear model, and we hypothesised that rotator cuff healing is impaired in the absence of a healthy SSN. Methods: Bilateral supraspinatus tenotomy from the great...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-03-01
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| Series: | Journal of Orthopaedic Translation |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214031X20300152 |
| _version_ | 1818591755088429056 |
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| author | Yucheng Sun Jae-Man Kwak Youlang Zhou Yan Fu Zhe Wang Qingzhong Chen In-Ho Jeon |
| author_facet | Yucheng Sun Jae-Man Kwak Youlang Zhou Yan Fu Zhe Wang Qingzhong Chen In-Ho Jeon |
| author_sort | Yucheng Sun |
| collection | DOAJ |
| description | Purpose: We designed a paired controlled study to investigate the role of the suprascapular nerve (SSN) in rotator cuff healing using a rat tear model, and we hypothesised that rotator cuff healing is impaired in the absence of a healthy SSN. Methods: Bilateral supraspinatus tenotomy from the great tuberosity was performed for 36 Wistar rats, which was then repaired immediately. A defect on the SSN was made on the right side, and a sham surgery was performed on the SSN at the left side. Twelve rats were sacrificed for biomechanical (six rats) and histological (six rats) testing, evaluated at 3, 6, and 9 weeks after surgery. Results: The bone–tendon junction on the nerve-intact side showed significantly better biomechanical characteristics than the nerve-injured side in terms of maximum load, maximum stress over time, stiffness at 9 weeks, and Young's modulus at 3 and 9 weeks. On the nerve-injured side, significantly smaller fibrocartilage layers and muscle fibres could be obtained over time. In addition, on the nerve-injured side, inferior bone–tendon interface formation was obtained in terms of cell maturity, cell alignment, collagen orientation, and the occurrence of tidemark and Sharpey's fibres through 9 weeks. In addition, neuropeptide Y was secreted in the nerve-intact group at 6 and 9 weeks. Conclusion: This study showed the inferior healing of the bone–tendon junction on the nerve-injured side compared with the nerve-intact side, which indicates that the SSN plays an important role in rotator cuff healing. Surgeons should pay more attention to SSN injury when treating patients with rotator cuff tear. |
| first_indexed | 2024-12-16T10:17:28Z |
| format | Article |
| id | doaj.art-b4971b779a5142beb9deac33678d182f |
| institution | Directory Open Access Journal |
| issn | 2214-031X |
| language | English |
| last_indexed | 2024-12-16T10:17:28Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Orthopaedic Translation |
| spelling | doaj.art-b4971b779a5142beb9deac33678d182f2022-12-21T22:35:24ZengElsevierJournal of Orthopaedic Translation2214-031X2021-03-0127153160Suprascapular nerve injury affects rotator cuff healing: A paired controlled study in a rat modelYucheng Sun0Jae-Man Kwak1Youlang Zhou2Yan Fu3Zhe Wang4Qingzhong Chen5In-Ho Jeon6Department of Hand Surgery, Affiliated Hospital of Nantong University, College of Medicine, University of Nantong, Nantong, China; Department of Orthopedic Surgery, ASAN Medical Center, College of Medicine, University of Ulsan, Seoul, South KoreaDepartment of Orthopedic Surgery, ASAN Medical Center, College of Medicine, University of Ulsan, Seoul, South KoreaDepartment of Hand Surgery, Affiliated Hospital of Nantong University, College of Medicine, University of Nantong, Nantong, ChinaDepartment of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Radiology, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Hand Surgery, Affiliated Hospital of Nantong University, College of Medicine, University of Nantong, Nantong, ChinaDepartment of Orthopedic Surgery, ASAN Medical Center, College of Medicine, University of Ulsan, Seoul, South Korea; Corresponding author. Department of Orthopedic Surgery, Asan Medical Center, College of Medicine, University of Ulsan, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.Purpose: We designed a paired controlled study to investigate the role of the suprascapular nerve (SSN) in rotator cuff healing using a rat tear model, and we hypothesised that rotator cuff healing is impaired in the absence of a healthy SSN. Methods: Bilateral supraspinatus tenotomy from the great tuberosity was performed for 36 Wistar rats, which was then repaired immediately. A defect on the SSN was made on the right side, and a sham surgery was performed on the SSN at the left side. Twelve rats were sacrificed for biomechanical (six rats) and histological (six rats) testing, evaluated at 3, 6, and 9 weeks after surgery. Results: The bone–tendon junction on the nerve-intact side showed significantly better biomechanical characteristics than the nerve-injured side in terms of maximum load, maximum stress over time, stiffness at 9 weeks, and Young's modulus at 3 and 9 weeks. On the nerve-injured side, significantly smaller fibrocartilage layers and muscle fibres could be obtained over time. In addition, on the nerve-injured side, inferior bone–tendon interface formation was obtained in terms of cell maturity, cell alignment, collagen orientation, and the occurrence of tidemark and Sharpey's fibres through 9 weeks. In addition, neuropeptide Y was secreted in the nerve-intact group at 6 and 9 weeks. Conclusion: This study showed the inferior healing of the bone–tendon junction on the nerve-injured side compared with the nerve-intact side, which indicates that the SSN plays an important role in rotator cuff healing. Surgeons should pay more attention to SSN injury when treating patients with rotator cuff tear.http://www.sciencedirect.com/science/article/pii/S2214031X20300152Bone–tendon interface healingRotator cuff tearRotator cuff repairSuprascapular nerve injuryMuscle atrophy |
| spellingShingle | Yucheng Sun Jae-Man Kwak Youlang Zhou Yan Fu Zhe Wang Qingzhong Chen In-Ho Jeon Suprascapular nerve injury affects rotator cuff healing: A paired controlled study in a rat model Journal of Orthopaedic Translation Bone–tendon interface healing Rotator cuff tear Rotator cuff repair Suprascapular nerve injury Muscle atrophy |
| title | Suprascapular nerve injury affects rotator cuff healing: A paired controlled study in a rat model |
| title_full | Suprascapular nerve injury affects rotator cuff healing: A paired controlled study in a rat model |
| title_fullStr | Suprascapular nerve injury affects rotator cuff healing: A paired controlled study in a rat model |
| title_full_unstemmed | Suprascapular nerve injury affects rotator cuff healing: A paired controlled study in a rat model |
| title_short | Suprascapular nerve injury affects rotator cuff healing: A paired controlled study in a rat model |
| title_sort | suprascapular nerve injury affects rotator cuff healing a paired controlled study in a rat model |
| topic | Bone–tendon interface healing Rotator cuff tear Rotator cuff repair Suprascapular nerve injury Muscle atrophy |
| url | http://www.sciencedirect.com/science/article/pii/S2214031X20300152 |
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