Pyoderma gangrenosum-like necrotizing panniculitis associated with Imatinib: A case report
Imatinib mesylate is a small tyrosine kinase inhibitor that targets BCR-ABL, ckit and platelet-derived growth factor receptor. It is prescribed by hematologists for chronic myeloid leukemia and acute lymphoblastic leukemia and by oncologists for Gastrointestinal Stromal Tumors (GIST). Cutaneous reac...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2020-07-01
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| Series: | Dermatology Reports |
| Subjects: | |
| Online Access: | https://www.pagepress.org/journals/index.php/dr/article/view/8381 |
| _version_ | 1818832685312770048 |
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| author | Jorge Hernández Parada Alicia Sanz Beatriz Isla-Tejera Juan Ruano |
| author_facet | Jorge Hernández Parada Alicia Sanz Beatriz Isla-Tejera Juan Ruano |
| author_sort | Jorge Hernández Parada |
| collection | DOAJ |
| description | Imatinib mesylate is a small tyrosine kinase inhibitor that targets BCR-ABL, ckit and platelet-derived growth factor receptor. It is prescribed by hematologists for chronic myeloid leukemia and acute lymphoblastic leukemia and by oncologists for Gastrointestinal Stromal Tumors (GIST). Cutaneous reactions to Imatinib are common but their incidence and severity widely varies between patients. A self-limited skin rash is the most common adverse effect but there have been reported cases of patients with maculopapular rash, pigmentary changes, superficial edema and rarer and clinically distinctive features such as lichenoid reactions or psoriasis. We here describe for the first time a case of pyoderma gangrenosum–like necrotizing panniculitis, a rare dermatological condition, after initiating therapy with Imatinib. |
| first_indexed | 2024-12-19T02:06:57Z |
| format | Article |
| id | doaj.art-b499375324fb49debdb561003083e4ba |
| institution | Directory Open Access Journal |
| issn | 2036-7392 2036-7406 |
| language | English |
| last_indexed | 2024-12-19T02:06:57Z |
| publishDate | 2020-07-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Dermatology Reports |
| spelling | doaj.art-b499375324fb49debdb561003083e4ba2022-12-21T20:40:54ZengPAGEPress PublicationsDermatology Reports2036-73922036-74062020-07-0112110.4081/dr.2020.8381Pyoderma gangrenosum-like necrotizing panniculitis associated with Imatinib: A case reportJorge Hernández Parada0Alicia Sanz1Beatriz Isla-Tejera2Juan Ruano3Department of Pharmacy, Reina Sofía University Hospital; Instituto Maimonides de Investigacion Biomedica de Cordoba - IMIBIC, Reina Sofía University Hospital, University of Cordoba, CórdobaDepartment of Pathology, Reina Sofía University Hospital, CórdobaDepartment of Pharmacy, Reina Sofía University Hospital; Instituto Maimonides de Investigacion Biomedica de Cordoba - IMIBIC, Reina Sofía University Hospital, University of Cordoba, CórdobaInstituto Maimonides de Investigacion Biomedica de Cordoba - IMIBIC, Reina Sofía University Hospital, University of Cordoba; Department of Dermatology, Reina Sofía University Hospital, Córdoba CórdobaImatinib mesylate is a small tyrosine kinase inhibitor that targets BCR-ABL, ckit and platelet-derived growth factor receptor. It is prescribed by hematologists for chronic myeloid leukemia and acute lymphoblastic leukemia and by oncologists for Gastrointestinal Stromal Tumors (GIST). Cutaneous reactions to Imatinib are common but their incidence and severity widely varies between patients. A self-limited skin rash is the most common adverse effect but there have been reported cases of patients with maculopapular rash, pigmentary changes, superficial edema and rarer and clinically distinctive features such as lichenoid reactions or psoriasis. We here describe for the first time a case of pyoderma gangrenosum–like necrotizing panniculitis, a rare dermatological condition, after initiating therapy with Imatinib.https://www.pagepress.org/journals/index.php/dr/article/view/8381Imatinibpyoderma gangrenosum- likenecrotizing panniculitis |
| spellingShingle | Jorge Hernández Parada Alicia Sanz Beatriz Isla-Tejera Juan Ruano Pyoderma gangrenosum-like necrotizing panniculitis associated with Imatinib: A case report Dermatology Reports Imatinib pyoderma gangrenosum- like necrotizing panniculitis |
| title | Pyoderma gangrenosum-like necrotizing panniculitis associated with Imatinib: A case report |
| title_full | Pyoderma gangrenosum-like necrotizing panniculitis associated with Imatinib: A case report |
| title_fullStr | Pyoderma gangrenosum-like necrotizing panniculitis associated with Imatinib: A case report |
| title_full_unstemmed | Pyoderma gangrenosum-like necrotizing panniculitis associated with Imatinib: A case report |
| title_short | Pyoderma gangrenosum-like necrotizing panniculitis associated with Imatinib: A case report |
| title_sort | pyoderma gangrenosum like necrotizing panniculitis associated with imatinib a case report |
| topic | Imatinib pyoderma gangrenosum- like necrotizing panniculitis |
| url | https://www.pagepress.org/journals/index.php/dr/article/view/8381 |
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