Impact of Preterm Birth on Neurodevelopmental Disorders in South Korea: A Nationwide Population-Based Study
Neurodevelopmental disorder (NDD) in preterm infants has become of great interest. We aimed to investigate the impact of preterm birth on the proportion of NDD using nationwide data provided by the Korean National Health Insurance Service. We included 4894 extremely preterm or extremely low-birth-we...
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MDPI AG
2022-04-01
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| author | Jong Ho Cha Ja-Hye Ahn Yun Jin Kim Bong Gun Lee Johanna Inhyang Kim Hyun-Kyung Park Bung-Nyun Kim Hyun Ju Lee |
| author_facet | Jong Ho Cha Ja-Hye Ahn Yun Jin Kim Bong Gun Lee Johanna Inhyang Kim Hyun-Kyung Park Bung-Nyun Kim Hyun Ju Lee |
| author_sort | Jong Ho Cha |
| collection | DOAJ |
| description | Neurodevelopmental disorder (NDD) in preterm infants has become of great interest. We aimed to investigate the impact of preterm birth on the proportion of NDD using nationwide data provided by the Korean National Health Insurance Service. We included 4894 extremely preterm or extremely low-birth-weight (EP/ELBW; <28 weeks of gestation or birth weight < 1000 g) infants, 70,583 other preterm or low-birth-weight (OP/LBW; 28–36 weeks of gestation or birth weight < 2500 g) infants, and 264,057 full-term infants born between 2008 and 2015. We observed their neurodevelopment until 6 years of age or until the year 2019, whichever occurred first. Diagnoses of NDDs were based on the World Health Organization’s International Classification of Diseases 10th revision. An association between preterm birth and NDD was assessed using a multivariable logistic regression model. There was a stepwise increase in the risk of overall NDD with increasing degree of prematurity, from OP/LBW (adjusted odds ratio 4.46; 95% confidence interval 4.34–4.58), to EP/ELBW (16.15; 15.21–17.15). The EP/ELBW group was strongly associated with developmental delay (21.47; 20.05–22.99), cerebral palsy (88.11; 79.89–97.19), and autism spectrum disorder (11.64; 10.37–13.06). Preterm birth considerably increased the risk of NDD by the degree of prematurity. |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T04:01:43Z |
| publishDate | 2022-04-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-b49960f142a74b329d476c555fb1cb512023-11-23T08:32:52ZengMDPI AGJournal of Clinical Medicine2077-03832022-04-01119247610.3390/jcm11092476Impact of Preterm Birth on Neurodevelopmental Disorders in South Korea: A Nationwide Population-Based StudyJong Ho Cha0Ja-Hye Ahn1Yun Jin Kim2Bong Gun Lee3Johanna Inhyang Kim4Hyun-Kyung Park5Bung-Nyun Kim6Hyun Ju Lee7Department of Pediatrics, Hanyang University Hospital, Hanyang University College of Medicine, Seoul 04763, KoreaDepartment of Pediatrics, Hanyang University Hospital, Hanyang University College of Medicine, Seoul 04763, KoreaBiostatistical Consulting and Research Lab, Medical Research Collaborating Center, Hanyang University, Seoul 04763, KoreaDepartment of Orthopedic Surgery, Hanyang University Hospital, Hanyang University College of Medicine, Seoul 04763, KoreaClinical Research Institute of Developmental Medicine, Hanyang University Hospital, Seoul 04763, KoreaDepartment of Pediatrics, Hanyang University Hospital, Hanyang University College of Medicine, Seoul 04763, KoreaDivision of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital, Seoul 03080, KoreaDepartment of Pediatrics, Hanyang University Hospital, Hanyang University College of Medicine, Seoul 04763, KoreaNeurodevelopmental disorder (NDD) in preterm infants has become of great interest. We aimed to investigate the impact of preterm birth on the proportion of NDD using nationwide data provided by the Korean National Health Insurance Service. We included 4894 extremely preterm or extremely low-birth-weight (EP/ELBW; <28 weeks of gestation or birth weight < 1000 g) infants, 70,583 other preterm or low-birth-weight (OP/LBW; 28–36 weeks of gestation or birth weight < 2500 g) infants, and 264,057 full-term infants born between 2008 and 2015. We observed their neurodevelopment until 6 years of age or until the year 2019, whichever occurred first. Diagnoses of NDDs were based on the World Health Organization’s International Classification of Diseases 10th revision. An association between preterm birth and NDD was assessed using a multivariable logistic regression model. There was a stepwise increase in the risk of overall NDD with increasing degree of prematurity, from OP/LBW (adjusted odds ratio 4.46; 95% confidence interval 4.34–4.58), to EP/ELBW (16.15; 15.21–17.15). The EP/ELBW group was strongly associated with developmental delay (21.47; 20.05–22.99), cerebral palsy (88.11; 79.89–97.19), and autism spectrum disorder (11.64; 10.37–13.06). Preterm birth considerably increased the risk of NDD by the degree of prematurity.https://www.mdpi.com/2077-0383/11/9/2476neurodevelopmental disorderpreterm birthautism spectrum disorderdevelopmental delaynationwide cohort |
| spellingShingle | Jong Ho Cha Ja-Hye Ahn Yun Jin Kim Bong Gun Lee Johanna Inhyang Kim Hyun-Kyung Park Bung-Nyun Kim Hyun Ju Lee Impact of Preterm Birth on Neurodevelopmental Disorders in South Korea: A Nationwide Population-Based Study Journal of Clinical Medicine neurodevelopmental disorder preterm birth autism spectrum disorder developmental delay nationwide cohort |
| title | Impact of Preterm Birth on Neurodevelopmental Disorders in South Korea: A Nationwide Population-Based Study |
| title_full | Impact of Preterm Birth on Neurodevelopmental Disorders in South Korea: A Nationwide Population-Based Study |
| title_fullStr | Impact of Preterm Birth on Neurodevelopmental Disorders in South Korea: A Nationwide Population-Based Study |
| title_full_unstemmed | Impact of Preterm Birth on Neurodevelopmental Disorders in South Korea: A Nationwide Population-Based Study |
| title_short | Impact of Preterm Birth on Neurodevelopmental Disorders in South Korea: A Nationwide Population-Based Study |
| title_sort | impact of preterm birth on neurodevelopmental disorders in south korea a nationwide population based study |
| topic | neurodevelopmental disorder preterm birth autism spectrum disorder developmental delay nationwide cohort |
| url | https://www.mdpi.com/2077-0383/11/9/2476 |
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