Effectiveness of oral pentosan polysulfate in painful bladder syndrome: Is it worth the cost?
Introduction: Oral pentosan polysulfate (PPS) is a recommended treatment in painful bladder syndrome (PBS); efficacy and cost-effectiveness of PPS have not been compared against the treatment with anticholinergics. Aim: This pilot study compared the effectiveness of oral PPS and anticholinergics and...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | MGM Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://www.mgmjms.com/article.asp?issn=2347-7946;year=2021;volume=8;issue=1;spage=3;epage=8;aulast=Palnitkar |
| _version_ | 1818677240594956288 |
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| author | Devdatt Purushottam Palnitkar Prakash Patankar Suresh Patankar |
| author_facet | Devdatt Purushottam Palnitkar Prakash Patankar Suresh Patankar |
| author_sort | Devdatt Purushottam Palnitkar |
| collection | DOAJ |
| description | Introduction: Oral pentosan polysulfate (PPS) is a recommended treatment in painful bladder syndrome (PBS); efficacy and cost-effectiveness of PPS have not been compared against the treatment with anticholinergics. Aim: This pilot study compared the effectiveness of oral PPS and anticholinergics and the cost of treatment for both. Materials and Methods: Thirty consecutive female patients presenting in Urology outpatient clinics were included in the study after obtaining clearance from the research and ethics committee. Twelve patients in each arm A and B completed the course of treatment and follow-up. Patients in each group were comparable symptomatically and epidemiologically. The patients in group A received oral PPS 100 mg three times daily for 3 months, whereas the patients in group B received anticholinergic drugs (oxybutynin chloride 2.5 mg twice daily) for 3 months. Efficacy based on symptom score and quality of life (QoL) scores along with cost-effectiveness was compared between the two groups. Results: In relief of symptoms and improvement in the QoL, there was no statistical difference in the findings of the two groups. The cost of therapy for the two groups was significantly different (P = 0.09). The cost of treatment with PPS was higher by two to three times the cost of treatment in the other groups. Conclusion: PPS does not offer any therapeutic advantage over oxybutynin chloride and is a costlier form of treatment. |
| first_indexed | 2024-12-17T08:56:14Z |
| format | Article |
| id | doaj.art-b49a7fa2c959470aad3bb4513746001c |
| institution | Directory Open Access Journal |
| issn | 2347-7946 2347-7962 |
| language | English |
| last_indexed | 2024-12-17T08:56:14Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | MGM Journal of Medical Sciences |
| spelling | doaj.art-b49a7fa2c959470aad3bb4513746001c2022-12-21T21:55:57ZengWolters Kluwer Medknow PublicationsMGM Journal of Medical Sciences2347-79462347-79622021-01-01813810.4103/mgmj.mgmj_75_20Effectiveness of oral pentosan polysulfate in painful bladder syndrome: Is it worth the cost?Devdatt Purushottam PalnitkarPrakash PatankarSuresh PatankarIntroduction: Oral pentosan polysulfate (PPS) is a recommended treatment in painful bladder syndrome (PBS); efficacy and cost-effectiveness of PPS have not been compared against the treatment with anticholinergics. Aim: This pilot study compared the effectiveness of oral PPS and anticholinergics and the cost of treatment for both. Materials and Methods: Thirty consecutive female patients presenting in Urology outpatient clinics were included in the study after obtaining clearance from the research and ethics committee. Twelve patients in each arm A and B completed the course of treatment and follow-up. Patients in each group were comparable symptomatically and epidemiologically. The patients in group A received oral PPS 100 mg three times daily for 3 months, whereas the patients in group B received anticholinergic drugs (oxybutynin chloride 2.5 mg twice daily) for 3 months. Efficacy based on symptom score and quality of life (QoL) scores along with cost-effectiveness was compared between the two groups. Results: In relief of symptoms and improvement in the QoL, there was no statistical difference in the findings of the two groups. The cost of therapy for the two groups was significantly different (P = 0.09). The cost of treatment with PPS was higher by two to three times the cost of treatment in the other groups. Conclusion: PPS does not offer any therapeutic advantage over oxybutynin chloride and is a costlier form of treatment.http://www.mgmjms.com/article.asp?issn=2347-7946;year=2021;volume=8;issue=1;spage=3;epage=8;aulast=Palnitkaroxybutynin chloridepainful bladder syndromepentosan polysulfatequality of life |
| spellingShingle | Devdatt Purushottam Palnitkar Prakash Patankar Suresh Patankar Effectiveness of oral pentosan polysulfate in painful bladder syndrome: Is it worth the cost? MGM Journal of Medical Sciences oxybutynin chloride painful bladder syndrome pentosan polysulfate quality of life |
| title | Effectiveness of oral pentosan polysulfate in painful bladder syndrome: Is it worth the cost? |
| title_full | Effectiveness of oral pentosan polysulfate in painful bladder syndrome: Is it worth the cost? |
| title_fullStr | Effectiveness of oral pentosan polysulfate in painful bladder syndrome: Is it worth the cost? |
| title_full_unstemmed | Effectiveness of oral pentosan polysulfate in painful bladder syndrome: Is it worth the cost? |
| title_short | Effectiveness of oral pentosan polysulfate in painful bladder syndrome: Is it worth the cost? |
| title_sort | effectiveness of oral pentosan polysulfate in painful bladder syndrome is it worth the cost |
| topic | oxybutynin chloride painful bladder syndrome pentosan polysulfate quality of life |
| url | http://www.mgmjms.com/article.asp?issn=2347-7946;year=2021;volume=8;issue=1;spage=3;epage=8;aulast=Palnitkar |
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