Enhanced effects of cigarette smoke extract on inflammatory cytokine expression in IL-1β-activated human mast cells were inhibited by Baicalein via regulation of the NF-κB pathway

Enhanced effects of cigarette smoke extract on inflammatory cytokine expression in IL-1β-activated human mast cells were inhibited by Baicalein via regulation of the NF-κB pathway

<p>Abstract</p> <p>Background</p> <p>Human mast cells are capable of a wide variety of inflammatory responses and play a vital role in the pathogenesis of inflammatory diseases such as allergy, asthma, and atherosclerosis. We have reported that cigarette smoke extract (...

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Bibliographic Details
Main Authors: Chi David S, Lin Ta-Chang, Hall Kenton, Ha Tuanzhu, Li Chuanfu, Wu Zong, Soike Thomas, Krishnaswamy Guha
Format: Article
Language:English
Published: BMC 2012-02-01
Series:Clinical and Molecular Allergy
Subjects:
Mast cell
cigarette smoking
Baicalein
IL-6
IL-8
NF-κB activation
IκBα phosphorylation and degradation
Online Access:http://www.clinicalmolecularallergy.com/content/10/1/3

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